Eiko Fried
@eikofried.bsky.social
Associate Prof Leiden Uni. Studying mental health problems as systems. http://eiko-fried.com. Building an early warning system for depression at http://WARN-D.com.
Pinned
Eiko Fried
@eikofried.bsky.social
· Nov 22
So many new followers!! Hi folks, nice to meet you all. 🖤
I'll introduce my core research interests by showing you some of the work we've done in recent years on the conceptualization, measurement, modeling, and theories of mental health (problems).
🧪 #PsychSciSky #psychiatry #statssky
🧵
I'll introduce my core research interests by showing you some of the work we've done in recent years on the conceptualization, measurement, modeling, and theories of mental health (problems).
🧪 #PsychSciSky #psychiatry #statssky
🧵
Facebook just reminded me it's been 12 years since I happened to sit next to Apocalyptica on the plane from Brussels to Berlin
November 28, 2025 at 12:28 AM
Facebook just reminded me it's been 12 years since I happened to sit next to Apocalyptica on the plane from Brussels to Berlin
1/2
New open access paper in which we apply the Nyquist-Shannon thereom from signal processing to 2 EMA datasets to figure out the optimal sampling frequency for EMA assessments.
🧪 #psychscisky #statssky
www.cambridge.org/core/journal...
New open access paper in which we apply the Nyquist-Shannon thereom from signal processing to 2 EMA datasets to figure out the optimal sampling frequency for EMA assessments.
🧪 #psychscisky #statssky
www.cambridge.org/core/journal...
Optimizing the frequency of ecological momentary assessments using signal processing | Psychological Medicine | Cambridge Core
Optimizing the frequency of ecological momentary assessments using signal processing - Volume 55
www.cambridge.org
November 27, 2025 at 12:04 AM
1/2
New open access paper in which we apply the Nyquist-Shannon thereom from signal processing to 2 EMA datasets to figure out the optimal sampling frequency for EMA assessments.
🧪 #psychscisky #statssky
www.cambridge.org/core/journal...
New open access paper in which we apply the Nyquist-Shannon thereom from signal processing to 2 EMA datasets to figure out the optimal sampling frequency for EMA assessments.
🧪 #psychscisky #statssky
www.cambridge.org/core/journal...
You’re no longer in the Netherlands when ..
November 25, 2025 at 6:19 AM
You’re no longer in the Netherlands when ..
Never change, ERC submission portal.
November 25, 2025 at 6:05 AM
Never change, ERC submission portal.
Reposted by Eiko Fried
Empirically, more extensive project descriptions do not affect the eventual decision anyway:
"We find that withholding proposal texts from panelists did not
detectibly impact their proposal rankings."
link.springer.com/article/10.1...
"We find that withholding proposal texts from panelists did not
detectibly impact their proposal rankings."
link.springer.com/article/10.1...
Do grant proposal texts matter for funding decisions? A field experiment - Scientometrics
Scientists and funding agencies invest considerable resources in writing and evaluating grant proposals. But do grant proposal texts noticeably change panel decisions in single blind review? We report...
link.springer.com
November 24, 2025 at 7:13 AM
Empirically, more extensive project descriptions do not affect the eventual decision anyway:
"We find that withholding proposal texts from panelists did not
detectibly impact their proposal rankings."
link.springer.com/article/10.1...
"We find that withholding proposal texts from panelists did not
detectibly impact their proposal rankings."
link.springer.com/article/10.1...
NL funder NWO recently changed rules for grant applications to endorse more modern recognition & reward practices.
But in my reading, the updated preproposal rules (CV, output, & just the slightest teensy weensy hint of a research idea) fully lean into Matthew effect.
Thoughts?
But in my reading, the updated preproposal rules (CV, output, & just the slightest teensy weensy hint of a research idea) fully lean into Matthew effect.
Thoughts?
November 24, 2025 at 4:16 AM
NL funder NWO recently changed rules for grant applications to endorse more modern recognition & reward practices.
But in my reading, the updated preproposal rules (CV, output, & just the slightest teensy weensy hint of a research idea) fully lean into Matthew effect.
Thoughts?
But in my reading, the updated preproposal rules (CV, output, & just the slightest teensy weensy hint of a research idea) fully lean into Matthew effect.
Thoughts?
Calling this "challenging scientific orthodoxy" is a wild euphemism, NYT.
Breaking News: Robert F. Kennedy Jr. said he personally instructed the CDC to abandon its position that vaccines do not cause autism. The move underscores his determination to challenge scientific orthodoxy — in this case, that vaccines save lives — and bend the health department to his will.
RFK Jr. Says He Instructed CDC to Change Vaccines and Autism Language on Website
In an interview, Health Secretary Robert F. Kennedy Jr. cited gaps in vaccine safety research. His critics say he is ignoring a larger point: Vaccines save lives.
nyti.ms
November 22, 2025 at 12:17 AM
Calling this "challenging scientific orthodoxy" is a wild euphemism, NYT.
Either my understanding of the term 'unanimously' is flawed, or basically all US newsmedia in the last 24 hours have used the term incorrectly.
November 20, 2025 at 7:13 AM
Either my understanding of the term 'unanimously' is flawed, or basically all US newsmedia in the last 24 hours have used the term incorrectly.
1/2
"In the last twenty years, countless attempts have been made to improve on the intuitive classifications of the past by subjecting clinical ratings, systematically collected from large populations of patients, to various forms of multivariate analysis. The result, as we have seen, ..
"In the last twenty years, countless attempts have been made to improve on the intuitive classifications of the past by subjecting clinical ratings, systematically collected from large populations of patients, to various forms of multivariate analysis. The result, as we have seen, ..
November 20, 2025 at 5:49 AM
1/2
"In the last twenty years, countless attempts have been made to improve on the intuitive classifications of the past by subjecting clinical ratings, systematically collected from large populations of patients, to various forms of multivariate analysis. The result, as we have seen, ..
"In the last twenty years, countless attempts have been made to improve on the intuitive classifications of the past by subjecting clinical ratings, systematically collected from large populations of patients, to various forms of multivariate analysis. The result, as we have seen, ..
"Just why a scientist has a right to treat as elementary a subsystem that is in fact exceedingly complex is one of the questions we shall take up. For now, we shall accept the fact that scientists do this all the time & that if they are careful scientists they usually get away with it" (Herbert '62)
November 20, 2025 at 3:56 AM
"Just why a scientist has a right to treat as elementary a subsystem that is in fact exceedingly complex is one of the questions we shall take up. For now, we shall accept the fact that scientists do this all the time & that if they are careful scientists they usually get away with it" (Herbert '62)
70 teaspoons placed in tearooms around the institute & observed weekly over 5 months. 80% of spoons disappeared; spoon halflife~81 days. Communal room halflife lower than in specific labs. 250 spoons annually required to maintain 70 spoon population.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
The case of the disappearing teaspoons: longitudinal cohort study of the displacement of teaspoons in an Australian research institute
Objectives To determine the overall rate of loss of workplace teaspoons and whether attrition and displacement are correlated with the relative value of the teaspoons or type of tearoom. Design Longitudinal cohort study. Setting Research institute ...
pmc.ncbi.nlm.nih.gov
November 20, 2025 at 3:44 AM
70 teaspoons placed in tearooms around the institute & observed weekly over 5 months. 80% of spoons disappeared; spoon halflife~81 days. Communal room halflife lower than in specific labs. 250 spoons annually required to maintain 70 spoon population.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Turns out my coffee sips appear to have roughly similar volume.
November 20, 2025 at 3:21 AM
Turns out my coffee sips appear to have roughly similar volume.
November 20, 2025 at 3:14 AM
Reposted by Eiko Fried
People are holding administrative burden parties to collectively take on tasks
www.wsj.com/lifestyle/re...
www.wsj.com/lifestyle/re...
Essay | How to Turn the Bureaucratic Grind of Life Into a Party
We all feel it: the growing stream of administrative tasks sapping our time, spirits and social lives. Admin Night represents a tiny, nerdy resistance.
www.wsj.com
November 19, 2025 at 12:54 PM
People are holding administrative burden parties to collectively take on tasks
www.wsj.com/lifestyle/re...
www.wsj.com/lifestyle/re...
Anyone planning to go to APS 2026 working on clinical prediction models? We have a nice preprint on predicting depression severity in n~1700 using smartphone & smartwatch data, and would love to join a symposium or help putting one together :)
www.psychologicalscience.org/conventions/...
www.psychologicalscience.org/conventions/...
November 19, 2025 at 2:39 AM
Anyone planning to go to APS 2026 working on clinical prediction models? We have a nice preprint on predicting depression severity in n~1700 using smartphone & smartwatch data, and would love to join a symposium or help putting one together :)
www.psychologicalscience.org/conventions/...
www.psychologicalscience.org/conventions/...
Nice NYT travel section piece on Leiden :). The photo at the top right of the website shows, incidentally, one of my favourite bridges in the Netherlands!
www.nytimes.com/2025/11/12/t...
www.nytimes.com/2025/11/12/t...
All the Canals and Charm of Amsterdam. None of the Crowds.
www.nytimes.com
November 14, 2025 at 8:49 AM
Nice NYT travel section piece on Leiden :). The photo at the top right of the website shows, incidentally, one of my favourite bridges in the Netherlands!
www.nytimes.com/2025/11/12/t...
www.nytimes.com/2025/11/12/t...
After having followed papers on the gut microbiome and mental health problems for a few years, I would not be surprised if conceptual and methodological flaws undermine most claims in this literature.
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 14, 2025 at 7:24 AM
After having followed papers on the gut microbiome and mental health problems for a few years, I would not be surprised if conceptual and methodological flaws undermine most claims in this literature.
The observed smallest worthwhile difference in this study "means that the current 15% antidepressant benefit over no treatment was sufficient for 1 in 3 people to accept antidepressants given the burdens, but 2 in 3 expected greater treatment benefits."
The average SWD for antidepressants for MDD was RD of 20%, and SMD of around 0.5. mentalhealth.bmj.com/content/27/1...
November 13, 2025 at 3:41 AM
The observed smallest worthwhile difference in this study "means that the current 15% antidepressant benefit over no treatment was sufficient for 1 in 3 people to accept antidepressants given the burdens, but 2 in 3 expected greater treatment benefits."
I'm in Sydney until December 15th.
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
a close up of a feather on a rock with the words `` hello '' written in white letters .
ALT: a close up of a feather on a rock with the words `` hello '' written in white letters .
media.tenor.com
November 12, 2025 at 3:42 AM
I'm in Sydney until December 15th.
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
Four interesting methods & stats winter courses at Leiden University also open to researchers and PhD candidates who are not affiliated with us.
www.universiteitleiden.nl/en/social-be...
www.universiteitleiden.nl/en/social-be...
November 10, 2025 at 9:20 PM
Four interesting methods & stats winter courses at Leiden University also open to researchers and PhD candidates who are not affiliated with us.
www.universiteitleiden.nl/en/social-be...
www.universiteitleiden.nl/en/social-be...
Reposted by Eiko Fried
This one surely has something on offer for every one: In this cross-sectional mediation analysis, the "effects" of soft drink consumption on depression were "mediated" by abundance of Eggerthela in the gut microbiome.
This was sent to me via dm and now you all got to suffer as well.
This was sent to me via dm and now you all got to suffer as well.
Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations
This cohort study examines the association between soft drink consumption and major depressive disorder diagnosis and severity and whether this association is mediated by changes in the gut microbiota...
jamanetwork.com
November 9, 2025 at 7:19 AM
This one surely has something on offer for every one: In this cross-sectional mediation analysis, the "effects" of soft drink consumption on depression were "mediated" by abundance of Eggerthela in the gut microbiome.
This was sent to me via dm and now you all got to suffer as well.
This was sent to me via dm and now you all got to suffer as well.
This thread has everything I loved about Twitter 2017/2018: several thoughtful expert suggestions that cover different angles, interspersed with excellent jokes, trolling of scientific journals, and philosophical debates about aging.
"Journal style does not allow 3-dimensional figures. Please rework Figure 5 into a figure with only 2 axes if possible"
a man in a suit and tie is smoking a cigarette while sitting in an airplane .
ALT: a man in a suit and tie is smoking a cigarette while sitting in an airplane .
media.tenor.com
November 6, 2025 at 12:08 AM
This thread has everything I loved about Twitter 2017/2018: several thoughtful expert suggestions that cover different angles, interspersed with excellent jokes, trolling of scientific journals, and philosophical debates about aging.
Been thinking for a few years about what I call the *replication ceiling*: the maximum replicability of an effect given constraints in data in which replication takes place (power, measurement error, sampling variability, etc). This leads to a maximum theoretical replicability which can be achieved.
November 5, 2025 at 3:09 AM
Been thinking for a few years about what I call the *replication ceiling*: the maximum replicability of an effect given constraints in data in which replication takes place (power, measurement error, sampling variability, etc). This leads to a maximum theoretical replicability which can be achieved.
Love everything about this, from the suggestive“Yes!” to back pain all the way to the “free” consultation.
November 5, 2025 at 2:16 AM
Love everything about this, from the suggestive“Yes!” to back pain all the way to the “free” consultation.
"Journal style does not allow 3-dimensional figures. Please rework Figure 5 into a figure with only 2 axes if possible"
a man in a suit and tie is smoking a cigarette while sitting in an airplane .
ALT: a man in a suit and tie is smoking a cigarette while sitting in an airplane .
media.tenor.com
November 4, 2025 at 8:44 PM
"Journal style does not allow 3-dimensional figures. Please rework Figure 5 into a figure with only 2 axes if possible"