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elenapugacheva.bsky.social
Elena M. Pugacheva, PhD
@elenapugacheva.bsky.social
10 followers 3 following 4 posts
Enthusiastic Staff Scientist at the National Institutes of Health, focusing on CTCF and its paralog BORIS (CTCFL), unraveling how their interactions shape 3D genome organization during spermatogenesis and contribute to cancer development and progression.
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elenapugacheva.bsky.social
Elena M. Pugacheva, PhD @elenapugacheva.bsky.social · Jul 8
But when CTCF is released from chromatin, a nucleosome takes its place. To bind again, CTCF must start the struggle anew, pushing the nucleosome aside once more.
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elenapugacheva.bsky.social
Elena M. Pugacheva, PhD @elenapugacheva.bsky.social · Jul 8
Like Sisyphus eternally pushing his boulder uphill, CTCF is depicted pushing a nucleosome, the fundamental unit of chromatin, up a hill. CTCF's constant effort causes the nucleosome to “slide” along the DNA, unwrapping at one end while wrapping at the other.
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elenapugacheva.bsky.social
Elena M. Pugacheva, PhD @elenapugacheva.bsky.social · Jul 8
Excited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/...
It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate the endless work of CTCF in shaping the 3D genome architecture.
CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation
Abstract. CTCF binding sites serve as anchors for the 3D chromatin architecture in vertebrates. The functionality of these anchors is influenced by the res
academic.oup.com
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elenapugacheva.bsky.social
Elena M. Pugacheva, PhD @elenapugacheva.bsky.social · Jul 8
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