Ellen Leffler
@ellenleffler.bsky.social
200 followers 150 following 10 posts
Assistant prof of human genetics @ UUtah. Language and food enthusiast, mom.
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ellenleffler.bsky.social
Thanks to a constructive peer review, the published paper in PLoS Pathogens is stronger than the preprint, so thanks to the editor and reviewers!
ellenleffler.bsky.social
We also identify genes with high SNP density, including genes in the Hep1 and Hep2 gene families, which are unique to Hepatocystis. This might suggest they are under selection for immune evasion, despite Hepatocystis lacking blood stage replication.
ellenleffler.bsky.social
This gave us low-coverage whole-genome sequencing data for Hepatocystis from baboons and five species of Chlorocebus monkeys-- and so a first look at genetic variation and population structure genome-wide. There is support for substructure by host species, which was not as clear from mtDNA only.
ellenleffler.bsky.social
Congrats to the lab! We were parasites of parasite data, and recovered DNA sequences from Hepatocystis (a close relative of human malaria parasites) from 37 wild non-human primates originally sequenced to look at the host genome, whose blood happened to be sampled while infected. shorturl.at/KluV8
Phylogenetics and genomic variation of Hepatocystis isolated from shotgun sequencing of wild primate hosts
Author summary Non-human primates are hosts to many species of Plasmodium, the parasites that cause malaria, and a closely related group of parasites called Hepatocystis. However, due to restrictions ...
shorturl.at
ellenleffler.bsky.social
Thanks to a constructive peer review, the published paper in PLoS Pathogens is stronger than the preprint, so thanks to the editor and reviewers!
ellenleffler.bsky.social
We also identify genes with high SNP density, including genes in the Hep1 and Hep2 gene familiels, which are unique to Hepatocystis. This might suggest they are under selection for immune evasion, despite Hepatocystis lacking blood stage replication
ellenleffler.bsky.social
This gave us low-coverage whole-genome sequencing data for Hepatocystis from baboons and five species of Chlorocebus monkeys-- and so a first look at genetic variation and population structure genome-wide. There is support for substructure by host species, which was not as clear from mtDNA only.
ellenleffler.bsky.social
Postdocs: Human Genetics at Utah will be hosting our annual Rising Stars in Genetics and Genomics Symposium in Sept. Apply here: shorturl.at/wBMg2
There will be sessions on developmental, evolutionary and disease genetics. A chance be invited to SLC to network here and with peers! Please share.
Reposted by Ellen Leffler
caina89.bsky.social
Quantgen GRC (16-21 Feb 2025) updates: we are now 75% subscribed!

Deadline: 19 Jan 2025

BUT: We will pick talks from submitted abstracts 16 Dec and aim to send decisions before Xmas. So submit your abstracts now (even if not perfect - editable after submission)!

www.grc.org/quantitative...
2025 Quantitative Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
ellenleffler.bsky.social
Recently learned about preLights -- and happy to support Alejandra (postdoc in the lab) as a contributor to highlight and generate discussion around preprints in evolutionary biology!
t.co/oaiz287N4a
A direct experimental test of Ohno’s hypothesis - preLights
An experimental system to test hypotheses on the evolution of gene duplication. Was S. Ohno right?
t.co