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Epilepsia Journal
@epilepsiajournal.bsky.social
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Epilepsia® – A Journal of the ILAE
Epilepsia® is the world's leading journal of original scientific research and commentary in epileptology. Impact Factor: 6.6. Epilepsia® publishes original articles on all aspects of epilepsy, clinical and experimental. T
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epilepsiajournal.bsky.social
This study evaluated the implementation and clinical effectiveness of a mental health care workflow for inpatients with epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antidepressants #anxiety #comorbidities #depression #healthrelatedqualityoflife #psychotherapy #seizurefrequency
November 21, 2025 at 6:35 PM
epilepsiajournal.bsky.social
Combining polygenic risk scores with rare variant data has potential to refine diagnostic accuracy and improve genetic counseling.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #DEE #genetics #penetrance #polygenic #PRS
November 21, 2025 at 6:34 PM
epilepsiajournal.bsky.social
This is the first placebo-controlled cenobamate efficacy study to use the globally approved cenobamate titration schedule.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiseizuremedication #efficacy #refractory #titration #cenobamate
November 21, 2025 at 6:33 PM
epilepsiajournal.bsky.social
Cenobamate demonstrates sustained seizure freedom and a favorable safety profile in patients with drug-resistant epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiepileptic #cenobamate #drugresistantepilepsy #seizurefreedom
November 20, 2025 at 5:21 PM
epilepsiajournal.bsky.social
Vagus nerve stimulation (VNS) showed a 90.5% responder rate and 20.5% seizure freedom in pediatric drug-resistant epilepsy over long-term follow-up
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #prognosticfactors #seizurefreedom #ultrarapiddutycycling #vagusnervestimulation
November 20, 2025 at 5:19 PM
epilepsiajournal.bsky.social
TBC1D24-related disorders encompass a wide spectrum of neurological phenotypes, but the longitudinal trajectories remain unexplored.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #DEE #genetics #HumanPhenotypeOntology #TBC1D24
November 19, 2025 at 7:02 PM
epilepsiajournal.bsky.social
Plasma biomarkers APOC4, SLC4A1, and S100B support early diagnosis of status epilepticus.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #biomarkers #earlydiagnosis #statusepilepticus
November 19, 2025 at 7:01 PM
epilepsiajournal.bsky.social
We review here the electrophysiological and pharmacological features of SD in models of epileptiform synchronization.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #ictogenesis #seizures #spreadingdepolarization #SUDEP
November 18, 2025 at 7:51 PM
epilepsiajournal.bsky.social
Findings reveal a positive association between the use of ASMs and survival in patients with PSE.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiseizuremedications #Italy #mortality #poststrokeepilepsy #publichealth
November 18, 2025 at 7:50 PM
epilepsiajournal.bsky.social
New in Epilepsia – November 15, 2025
mailchi.mp/ilae/new-art...

Subscribe - eepurl.com/iLSrNc

#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
November 17, 2025 at 4:25 PM
epilepsiajournal.bsky.social
Treating epilepsy with ASMs is thus akin to playing chess—a game in which strategic decisions must be made at each point in time and constantly reevaluated to beat the opponent.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiseizuremedications #chessboardgame #strategicdecisions
November 17, 2025 at 4:24 PM
epilepsiajournal.bsky.social
We observed an increased PVS volume fraction in the basal ganglia across all epilepsy types considered.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #glymphaticsystem #MRI #perivascularspaces
November 13, 2025 at 6:55 PM
epilepsiajournal.bsky.social
Lennox–Gastaut syndrome (LGS) management requires regular assessments and multidisciplinary care.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #LennoxGastaut #multidisciplinarycare #patientadvocacy
November 13, 2025 at 6:53 PM
epilepsiajournal.bsky.social
Letter to the Editor

Electroencephalographic signal dimension provides the necessary stability of measurements for the unbiased evaluation of ASMs, unlike seizure frequency: Overcoming drawbacks of seizure occurrence variability
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #seizure
November 12, 2025 at 4:02 PM
epilepsiajournal.bsky.social
DRPLA patients with epilepsy have earlier onset and longer CAG repeats than those without epilepsy.
onlinelibrary.wiley.com/doi/10.1111/...

#epilepsy #ILAE #epilepsia #antiseizuremedication #dentatorubralpallidoluysianatrophy #progressivemyoclonicepilepsy #trinucleotiderepeatdisorders
Epilepsy in dentatorubral–pallidoluysian atrophy: A systematic review and meta‐analysis
Summary of key clinical and electrophysiological characteristics of DRPLA-related epilepsy from a systematic review and meta-analysis of 1,191 patients. DRPLA patients with epilepsy showed earlier di...
onlinelibrary.wiley.com
November 12, 2025 at 3:59 PM
epilepsiajournal.bsky.social
Five de novo heterozygous SRCAP variants are identified in five patients with DEE, and six biallelic variants are identified in six patients with focal epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #SRCAP #denovovariants #DEE #geneticdependentquantity #genotypephenotypecorrelations
November 11, 2025 at 3:48 PM
epilepsiajournal.bsky.social
LOF Slc35a2 in oligodendrocytes results in severe hypomyelination, a reduction of oligodendrocytes, and reactive gliosis.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #hypomyelination #malformations #corticaldevelopment #MOGHE #Slc35a2
November 11, 2025 at 3:47 PM
epilepsiajournal.bsky.social
New in Epilepsia – November 8, 2025
mailchi.mp/ilae/new-art...

Subscribe - eepurl.com/iLSrNc

#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
November 10, 2025 at 3:50 PM
epilepsiajournal.bsky.social
We evaluated the efficacy and safety of adjunctive cenobamate (100, 200, and 400 mg/day) in Asian patients with uncontrolled focal seizures.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #focalepilepsy #phase3 #refractory
A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures
A randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures.
doi.org
November 10, 2025 at 3:48 PM
epilepsiajournal.bsky.social
Pilocarpine-induced SE elevates the respiratory rate and ventilation.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #apnea #cholinergicactivation #EEG #plethysmography #seizureinducedmortality
November 7, 2025 at 3:30 PM
epilepsiajournal.bsky.social
Absence seizures in monogenic epilepsies often show early onset, atypical features, drug-resistance, and poor developmental outcomes.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #atypicalabsence #epilepsyclassification #monogenic #neurodevelopment #nextgenerationsequencing
November 7, 2025 at 3:29 PM
epilepsiajournal.bsky.social
The effects of astrocyte Gq-coupled Designer Receptors Exclusively Activated by Designer Drugs modulation were investigated in a mouse model of temporal lobe epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #astrocytes #chemogeneticmodulation #DREADDs #metabolomics #temporallobe
November 7, 2025 at 3:28 PM
epilepsiajournal.bsky.social
De novo missense variants in BAIAP2 identified in six patients with severe DEEs, featuring refractory epilepsy, developmental delays, and intellectual disability.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #BAIAP2 #IRSp53 #DEE #intellectualdisability #wholeexomesequencing
November 6, 2025 at 5:08 PM
epilepsiajournal.bsky.social
Cluster analysis reveals distinct profiles based on age at onset, symptoms, cognitive level, presence of developmental and epileptic encephalopathy, disease mechanism, and treatment response.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #geneticepilepsy #pediatric #pediatricmovementdisorders
November 6, 2025 at 5:07 PM
epilepsiajournal.bsky.social
AI models integrating magnetic resonance imaging, clinical, and antiseizure medication (ASM) data predicted seizure freedom in newly diagnosed epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiseizuremedication #artificialintelligence #brainMRI #epilepsyimaging #machinelearning #AI
November 5, 2025 at 2:55 PM