Brendan Farrell
@farrellbrendan.bsky.social
Postdoc at Biochemistry Department and Kavli Institute, Uni of Oxford. #structuralbiology #malaria
How do antibodies against PfRIPR act to impede erythrocyte invasion? In our latest study, we isolate and structurally characterise a panel of human antibodies and the growth inhibitory antibody RP.012, revealing an unexpected story of synergy and antagonism that has consequences for vaccine design.
January 17, 2026 at 12:33 PM
How do antibodies against PfRIPR act to impede erythrocyte invasion? In our latest study, we isolate and structurally characterise a panel of human antibodies and the growth inhibitory antibody RP.012, revealing an unexpected story of synergy and antagonism that has consequences for vaccine design.
Reposted by Brendan Farrell
New online! Erythrocyte invasion in malaria: from molecular mechanisms to rational vaccines
Erythrocyte invasion in malaria: from molecular mechanisms to rational vaccines
Nature Reviews Microbiology, Published online: 15 September 2025; doi:10.1038/s41579-025-01235-1If erythrocyte invasion is blocked during the blood stage of infection by Plasmodium parasites, malaria can be prevented. In this Review, structural insights on erythrocyte invasion by the merozoite form of Plasmodium are discussed in the context of rational design of a blood-stage malaria vaccine.
www.nature.com
September 15, 2025 at 10:30 AM
New online! Erythrocyte invasion in malaria: from molecular mechanisms to rational vaccines
Reposted by Brendan Farrell
Extremely happy to share the first paper of my postdoc work with @parasitematt.
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6
June 12, 2025 at 11:42 AM
Extremely happy to share the first paper of my postdoc work with @parasitematt.
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6