Faryabi Lab @UPENN
@faryabi.bsky.social
Interested in epigenetics, cancer biology, and learning!
Pinned
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology
Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...
www.nature.com
Kudos to Yeqiao Zhou, @atishayjay.bsky.social, and @vahedilab.bsky.social for our new @natcellbio.nature.com study www.nature.com/articles/s41...! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.
Reposted by Faryabi Lab @UPENN
Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @faryabi.bsky.social @vahedilab.bsky.social @atishayjay.bsky.social
tinyurl.com/4nwfbeu2
tinyurl.com/4zaw5cn7
tinyurl.com/25snbf4j
tinyurl.com/4nwfbeu2
tinyurl.com/4zaw5cn7
tinyurl.com/25snbf4j
OLIVE provides rapid visualization and analysis of chromatin tracing experiments
Zhou et al. develop the optical looping interactive viewing engine (OLIVE), a web-based
application for browsing and exploring user-generated and publicly available chromatin
tracing datasets.
www.cell.com
December 2, 2025 at 5:30 PM
Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @faryabi.bsky.social @vahedilab.bsky.social @atishayjay.bsky.social
tinyurl.com/4nwfbeu2
tinyurl.com/4zaw5cn7
tinyurl.com/25snbf4j
tinyurl.com/4nwfbeu2
tinyurl.com/4zaw5cn7
tinyurl.com/25snbf4j
Reposted by Faryabi Lab @UPENN
Beyond excited to share the collaborative work with @faryabi.bsky.social led by stars Yeqiao Zhou and @atishayjay.bsky.social; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology. tinyurl.com/2st3afwf
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology
Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...
www.nature.com
December 2, 2025 at 3:57 PM
Beyond excited to share the collaborative work with @faryabi.bsky.social led by stars Yeqiao Zhou and @atishayjay.bsky.social; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology. tinyurl.com/2st3afwf
Reposted by Faryabi Lab @UPENN
With co-first author, CAMB Alum, Yeqiao Zhou from her time in the Faryabi Lab (@faryabi.bsky.social)
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ
@sciimmunology.bsky.social scim.ag/4o12TOZ
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.
scim.ag
December 1, 2025 at 8:52 PM
With co-first author, CAMB Alum, Yeqiao Zhou from her time in the Faryabi Lab (@faryabi.bsky.social)
Kudos to Yeqiao Zhou, @atishayjay.bsky.social, and @vahedilab.bsky.social for our new @natcellbio.nature.com study www.nature.com/articles/s41...! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology
Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...
www.nature.com
December 2, 2025 at 3:53 PM
Kudos to Yeqiao Zhou, @atishayjay.bsky.social, and @vahedilab.bsky.social for our new @natcellbio.nature.com study www.nature.com/articles/s41...! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.