PhD Project - NERC RED-ALERT CDT: Bacteriophages as river pollutants: determining the impact of phage pollution, with focus on antimicrobial resistance. at Bangor University, listed on FindAPhD.com

Dr Freya Harrison

Pseudomonas aeruginosa is a pathogen notorious for its antimicrobial resistance and is currently classified as a high-priority pathogen for which new drugs are needed. Tetrasodium EDTA (tEDTA) is one of the new antimicrobial compounds that have been shown to have good antibacterial and antibiofilm efficacy against P. aeruginosa. Due to the diversity and highly drug-tolerant nature of P. aeruginosa biofilms in different infection environments, it is important to carry out pre-clinical testing of new antibiofilm agents against this pathogen in media and models that accurately mimic diverse infection environments. In this study, we used different high validity media and biofilm models that mimic chronic wounds, endotracheal tubes, and cystic fibrosis lung infections to assess the efficacy of tEDTA against P. aeruginosa biofilms. We report that different infection environments influence the susceptibility of both planktonic and biofilm forms of P. aeruginosa to tEDTA. The highest tolerance to tEDTA was observed in the media and biofilm model that mimics the endotracheal tube environment. In conclusion, we show that although different infection environments influence the efficacy of tEDTA against P. aeruginosa biofilms, it has good potential for use as an alternative antimicrobial in treating P. aeruginosa-associated biofilm infections. ### Competing Interest Statement The authors have declared no competing interest.

Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.

PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com

Dr Melissa Webby

This week we are joined by members of The Vikings: Early reenactment members, Cathy & Paul Murphy. @thevikingsuk Paul is a society elder, and Cathy is a High Council Jarl and the ‘Konungr’, which is the leader of the society.  Both Cathy & Paul are a part of the oldest and largest Dark Age re-enactment society in the UK. The society is known for its high standard of presentation, historical accuracy, and attention to detail. They offer arena displays of hand-to-hand combat, with the larger battles involving well over three hundred warriors, bow and sling hunting demonstrations, walks through history through their tented encampments, and demos of crafting skills.#SundayBrunch #TheVikingsUKView all comments