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gastrulomicslab.bsky.social
@gastrulomicslab.bsky.social
83 followers 78 following 3 posts
Based in Freiburg/Germany in the Arnold-Lab, we are enthusiastic about various aspects of gastrulation: from cell behavior during morphogenesis, signals and transcriptional control, to dynamic chromatin regulation, and even biophysics of cells & tissues
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gastrulomicslab.bsky.social
gastrulomicslab.bsky.social @gastrulomicslab.bsky.social · Mar 13
Excited to share our latest paper in DevCell! We show how EOMES and the SWI/SNF complex collaborate to drive chromatin remodeling, establishing mesoderm and endoderm differentiation potential.

Read the full paper here: www.cell.com/developmenta...
EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling
Schröder et al. describe the molecular functions of the Tbx factor Eomes, which, together with the SWI/SNF chromatin remodeling complex, establishes enhancer accessibility at mesoderm and endoderm (ME...
www.cell.com
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gastrulomicslab.bsky.social
gastrulomicslab.bsky.social @gastrulomicslab.bsky.social · Dec 12
Thanks Benoît! Haha, next time I will be jealous reading your kickass papers!
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gastrulomicslab.bsky.social
gastrulomicslab.bsky.social @gastrulomicslab.bsky.social · Dec 11
Congrats Chiara to have your beauty paper out:
www.cell.com/developmenta...
EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling
Schröder et al. describe the molecular functions of the Tbx factor Eomes, which, together with the SWI/SNF chromatin remodeling complex, establishes enhancer accessibility at mesoderm and endoderm (ME) genes during lineage specification of pluripotent cells. Eomes enables broad ME lineage competence for gene activation that relies on additional signal-induced transcription factors.
www.cell.com
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