GEARs
@gearseminar.bsky.social
Gene expression and RNA Seminar Series in Boston area!
Please join us on November 20th! We are very grateful for our first sponsorship - Molecular Instrument!
November 18, 2025 at 7:39 PM
Please join us on November 20th! We are very grateful for our first sponsorship - Molecular Instrument!
Reposted by GEARs
Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...
ZMYND11 Restrains KMT2A to Enable a Neuronal Developmental Program
Mutations in the chromatin reader and tumor suppressor ZMYND11 are the cause of ZMYND11-related syndromic intellectual disability (ZRSID), a disorder characterized by symptoms such as language and mot...
www.biorxiv.org
November 4, 2025 at 11:37 PM
Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...
Reposted by GEARs
Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Integrator complex collapse: A mechanistic route to integrated stress response and disease
Integrator complex collapse: A mechanistic route to integrated stress response and disease
In a recent Cell article, Baluapuri et al. show that loss of the Integrator (INT) complex activates the integrated stress response via double-stranded RNA from incomplete pre-mRNAs, revealing a link to INT-related neurodevelopmental diseases and potential therapeutic targets.
dlvr.it
June 20, 2025 at 2:01 PM
Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Reposted by GEARs
Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social!
You can register at: us06web.zoom.us/webinar/regi...
You can register at: us06web.zoom.us/webinar/regi...
May 15, 2025 at 6:35 PM
Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social!
You can register at: us06web.zoom.us/webinar/regi...
You can register at: us06web.zoom.us/webinar/regi...
Reposted by GEARs
Outstanding work from Allison James who will graduate next month! If you like our work, consider applying to the Farnung Lab. More info: farnunglab.com
Farnung Lab
farnunglab.com
May 6, 2025 at 3:09 PM
Outstanding work from Allison James who will graduate next month! If you like our work, consider applying to the Farnung Lab. More info: farnunglab.com
Reposted by GEARs

🧬🎉Thrilled to share our new chromatin remodeling study! We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link: authors.elsevier.com/a/1l2ik3vVUP...
🧬🎉Thrilled to share our new chromatin remodeling study! We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link: authors.elsevier.com/a/1l2ik3vVUP...
May 6, 2025 at 3:08 PM

🧬🎉Thrilled to share our new chromatin remodeling study! We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link: authors.elsevier.com/a/1l2ik3vVUP...
🧬🎉Thrilled to share our new chromatin remodeling study! We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link: authors.elsevier.com/a/1l2ik3vVUP...
Excited to see everyone tonight at Whitehead Institute for the 2nd GEARS seminar, featuring three talks from Harleen Saini, Vikram Agarwal, and Ava Carter!
May 1, 2025 at 8:09 PM
Excited to see everyone tonight at Whitehead Institute for the 2nd GEARS seminar, featuring three talks from Harleen Saini, Vikram Agarwal, and Ava Carter!
Reposted by GEARs
What contributes to human specific neural specification? Check out these two wonderful preprints from a wonderful scientist Ava carter! 1. www.biorxiv.org/content/10.1...; 2. www.biorxiv.org/content/10.1...
Stay tuned! third preprint is on its way!
Stay tuned! third preprint is on its way!
Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulation
A major challenge in human evolutionary biology is to pinpoint genetic differences that underlie human-specific traits, such as increased neuron number and differences in cognitive behaviors. We used ...
www.biorxiv.org
April 2, 2025 at 7:24 PM
What contributes to human specific neural specification? Check out these two wonderful preprints from a wonderful scientist Ava carter! 1. www.biorxiv.org/content/10.1...; 2. www.biorxiv.org/content/10.1...
Stay tuned! third preprint is on its way!
Stay tuned! third preprint is on its way!
Reposted by GEARs
🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week!
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
March 23, 2025 at 2:02 PM
🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week!
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
Reposted by GEARs
🎆Next #FragileNucleosome meeting is less than a week away! We are delighted to host @manucazottes.bsky.social, @robertadolling1.bsky.social & @leandrosboukas.bsky.social ! We will discuss evolution of XIST regulatory network, cancer epigenetics, and MDEMs!
🗓️ us06web.zoom.us/webinar/regi...
🗓️ us06web.zoom.us/webinar/regi...
February 22, 2025 at 11:55 AM
🎆Next #FragileNucleosome meeting is less than a week away! We are delighted to host @manucazottes.bsky.social, @robertadolling1.bsky.social & @leandrosboukas.bsky.social ! We will discuss evolution of XIST regulatory network, cancer epigenetics, and MDEMs!
🗓️ us06web.zoom.us/webinar/regi...
🗓️ us06web.zoom.us/webinar/regi...
After a long break, GEARs is back! We will feature three speakers on Feb 27th, 6PM in Goldenson 122. Please register via docs.google.com/forms/d/e/1F... so we can get enough food and drinks. You can nominate speaker sor volunteer for our future seminars through docs.google.com/forms/d/e/1F....
February 14, 2025 at 3:28 AM
After a long break, GEARs is back! We will feature three speakers on Feb 27th, 6PM in Goldenson 122. Please register via docs.google.com/forms/d/e/1F... so we can get enough food and drinks. You can nominate speaker sor volunteer for our future seminars through docs.google.com/forms/d/e/1F....