It's finally published in ES&T:
We developed a PBK model for BPA analogues with a multimodal parameterization approach.
👉 yes we can! (predict biokinetics without in vivo data)
👉 analogues reach much higher internal concentrations than BPA

#toxicology #plastics #EDCs

pubs.acs.org/doi/10.1021/...

🌍 Our team had the privilege to showcase our latest advances in developing #NAMs under the equator at #WC13! ✨

🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling
🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics
⚖️ Hélène Bigonne – sex-informed PBK models

Huge news, as #BPA will be completely banned from food contact materials in Europe. I can already think of some BPA alternatives that should come next. :-)

food.ec.europa.eu/food-safety-...

Fazit: It's the economy, stupid.

Check out our new pre-print (submitted to EHP)! We developed PBTK models to predict ADME of six data-poor #BPA analogues in distinct population groups. Spoiler alert: they behave quite differently. A strong argument against read-across and considering replacement BPs "similar" to BPA in toxicity.

Hello Bluesky.
Winter wonderland in Zürich today. Can't imagine a better day to start this journey.

yes, totally!

Quite a day at the Annual Meeting of the Swiss Society of Toxicology with talks by @georgaichinger.bsky.social (microbiome-competent PK modeling) & @vakil-takhaveev.bsky.social (DNA damage sequencing).
Special Congrats to PhDs Alona Slastennikova and Blandine Descamps who received poster awards!💪🥳

Thrilled to share that the ETH Laboratory of Toxicology is now LIVE on BlueSky! Follow @sturlalab.bsky.social for updates on 🦠 #microbiome #science, 💻 #bioinformatics, 🧬 #dnadamage, and of course 🧪 #oncology.

Also: sneek peeks into our 🇨🇭 Swiss life and fun!