Author | Lightnews

gouthamnarla

@gouthamnarla.bsky.social

45 followers 230 following 2 posts

physician scientist, professor of medicine, drug hunter, biotech entrepreneur, father, husband, lover of food, wine, and golf

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gouthamnarla @gouthamnarla.bsky.social · 12d

Abstract B051: Discovery of SW-3431, a first-in-class molecular glue activator with potent and selective anti-tumor activity in PPP2R1A mutant cancers url: aacrjournals.org/mct/article/...

Abstract B051: Discovery of SW-3431, a first-in-class molecular glue activator with potent and selective anti-tumor activity in PPP2R1A mutant cancers

AbstractUterine cancer is the only cancer type for which survival has fallen in the past four decades. This past year, uterine cancer deaths surpassed ovarian cancer for the first time: making uterine...

aacrjournals.org

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Reposted by gouthamnarla

Caitlin O'Connor, PhD @pharmacocaitlin.bsky.social · Feb 5

Our new paper describing how mutations to the PP2A gene PPP2R1A drive high-grade uterine cancers is out now in this issue of Cancer Research by @theaacr.bsky.social

aacrjournals.org/cancerres/ar...

Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer

Elevated IGFBP2 secretion by uterine cancer cells with heterozygous PPP2R1A mutations supports tumor progression and confers a vulnerability to IGFBP2/IGF1R inhibition as a therapeutic approach for th...

aacrjournals.org

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Reposted by gouthamnarla

STITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 12d

Molecular Glue Boosts PP2A, Overcoming Resistance to RAS/MAPK Inhibitors in KRAS-Mutant Lung Cancer, Enhancing Survival Rates.

by Raines B, Tseng-Rogenski S (...) Narla G et 14 al. in J Clin Invest #MedSky

👉 get more here

📖 read the article: https://www.jci.org/articles/view/193790

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gouthamnarla @gouthamnarla.bsky.social · 14d

Exciting new finding about the role of PP2A molecular glues in overcoming resistant to broad classes of MAPK inhibitors in KRAS driven cancers
JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer www.jci.org/articles/vie...

JCI - A PP2A molecular glue overcomes ras/mapk inhibitor resistance in kras-mutant non-small cell lung cancer

www.jci.org

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