Guillermo Reales
@greales7.bsky.social
Senior scientist @ Genomics. Science, maracatú, cats, and a couple more things. 🇪🇦🇬🇧🇧🇷
Pinned
Guillermo Reales
@greales7.bsky.social
· Feb 19
RapidoPGS: A Fast and Light Package to Compute Polygenic Risk Scores
Quickly computes polygenic scores from GWAS summary statistics of either case-control or quantitative traits without parameter tuning. Reales,G., Vigorito, E., Kelemen,M., Wallace,C. (2021) <<a hre...
cran.r-project.org
RapidoPGS 2.3.1 is now available on CRAN 🥳 (cran.r-project.org/web/packages...).
Changes in dependencies were making RapidoPGS multi to fail. This new version should work as expected. Test it out!
Changes in dependencies were making RapidoPGS multi to fail. This new version should work as expected. Test it out!
Reposted by Guillermo Reales
I was today years old when I realized that the Chromosome 2 fusion event which is unique to modern humans probably coincides with a possible population bottleneck event ~900kya.
Could the one have caused the other?
This is my adaptation of the published figure
DOI: 10.1126/science.abq7487
Could the one have caused the other?
This is my adaptation of the published figure
DOI: 10.1126/science.abq7487
May 25, 2025 at 8:10 PM
I was today years old when I realized that the Chromosome 2 fusion event which is unique to modern humans probably coincides with a possible population bottleneck event ~900kya.
Could the one have caused the other?
This is my adaptation of the published figure
DOI: 10.1126/science.abq7487
Could the one have caused the other?
This is my adaptation of the published figure
DOI: 10.1126/science.abq7487
Reposted by Guillermo Reales
The most famous heuristic in mapping gwas snps to genes is "it's usually the closest gene".
But only slightly less well-known is this: consider the colocalized phenotypes.
That is, a genetic variant seldom disrupts exactly one phenotype.
What else does tugging on that thread do?
But only slightly less well-known is this: consider the colocalized phenotypes.
That is, a genetic variant seldom disrupts exactly one phenotype.
What else does tugging on that thread do?
April 13, 2025 at 6:36 PM
The most famous heuristic in mapping gwas snps to genes is "it's usually the closest gene".
But only slightly less well-known is this: consider the colocalized phenotypes.
That is, a genetic variant seldom disrupts exactly one phenotype.
What else does tugging on that thread do?
But only slightly less well-known is this: consider the colocalized phenotypes.
That is, a genetic variant seldom disrupts exactly one phenotype.
What else does tugging on that thread do?
Reposted by Guillermo Reales
I joined Will Dixon and the team at BBC’s Curious Cases to chat about how weather and seasons might influence inflammation and pain. A really fun conversation!
www.bbc.co.uk/sounds/play/...
www.bbc.co.uk/sounds/play/...
May 12, 2025 at 5:38 PM
I joined Will Dixon and the team at BBC’s Curious Cases to chat about how weather and seasons might influence inflammation and pain. A really fun conversation!
www.bbc.co.uk/sounds/play/...
www.bbc.co.uk/sounds/play/...
RapidoPGS 2.3.1 is now available on CRAN 🥳 (cran.r-project.org/web/packages...).
Changes in dependencies were making RapidoPGS multi to fail. This new version should work as expected. Test it out!
Changes in dependencies were making RapidoPGS multi to fail. This new version should work as expected. Test it out!
RapidoPGS: A Fast and Light Package to Compute Polygenic Risk Scores
Quickly computes polygenic scores from GWAS summary statistics of either case-control or quantitative traits without parameter tuning. Reales,G., Vigorito, E., Kelemen,M., Wallace,C. (2021) <<a hre...
cran.r-project.org
February 19, 2025 at 12:22 PM
RapidoPGS 2.3.1 is now available on CRAN 🥳 (cran.r-project.org/web/packages...).
Changes in dependencies were making RapidoPGS multi to fail. This new version should work as expected. Test it out!
Changes in dependencies were making RapidoPGS multi to fail. This new version should work as expected. Test it out!
Here we are, looking forward to 2 days of exciting Genomics! If you're at the event and in need of a Bioinformatician, I'm open for new positions! 😁
January 29, 2025 at 8:36 AM
Here we are, looking forward to 2 days of exciting Genomics! If you're at the event and in need of a Bioinformatician, I'm open for new positions! 😁