Molecular Instruments, Inc.
@hcrimaging.bsky.social
Inventors of HCR, protease-free RNA-ISH, and the game-changing HiFi Encoder for multiplex IF
What an exciting meeting at this month’s Gene Expression and RNA Series (GEARS) in Boston! Thank you to everyone who joined us for an introduction to the HCR™ platform.
Special shoutout to @xiaoliwu.bsky.social, jonmarkert.bsky.social, and @ara-latifkar.bsky.social for helping coordinate the event!
Special shoutout to @xiaoliwu.bsky.social, jonmarkert.bsky.social, and @ara-latifkar.bsky.social for helping coordinate the event!
November 24, 2025 at 8:10 PM
What an exciting meeting at this month’s Gene Expression and RNA Series (GEARS) in Boston! Thank you to everyone who joined us for an introduction to the HCR™ platform.
Special shoutout to @xiaoliwu.bsky.social, jonmarkert.bsky.social, and @ara-latifkar.bsky.social for helping coordinate the event!
Special shoutout to @xiaoliwu.bsky.social, jonmarkert.bsky.social, and @ara-latifkar.bsky.social for helping coordinate the event!
This year's SfN was a valuable opportunity to connect with the neuroscience community, share our latest work, and demonstrate how the HCR™ HiFi Encoder supports more adaptable multiplex IF.
Thank you to everyone who stopped by! We look forward to seeing you all again at future meetings.
Thank you to everyone who stopped by! We look forward to seeing you all again at future meetings.
November 20, 2025 at 7:34 PM
This year's SfN was a valuable opportunity to connect with the neuroscience community, share our latest work, and demonstrate how the HCR™ HiFi Encoder supports more adaptable multiplex IF.
Thank you to everyone who stopped by! We look forward to seeing you all again at future meetings.
Thank you to everyone who stopped by! We look forward to seeing you all again at future meetings.
With the HCR™ HiFi Encoder, @dhouston.bsky.social (@uiowabiology.bsky.social) ran two @dshb-antibodies.bsky.social mouse IgG1 antibodies directly from supernatant and achieved robust double-labeling using HCR™ Gold IF.
🔬 Ready to try HCR™ Gold IF? Get a free Starter Kit here: tinyurl.com/37dfdenf
🔬 Ready to try HCR™ Gold IF? Get a free Starter Kit here: tinyurl.com/37dfdenf
November 18, 2025 at 7:07 PM
With the HCR™ HiFi Encoder, @dhouston.bsky.social (@uiowabiology.bsky.social) ran two @dshb-antibodies.bsky.social mouse IgG1 antibodies directly from supernatant and achieved robust double-labeling using HCR™ Gold IF.
🔬 Ready to try HCR™ Gold IF? Get a free Starter Kit here: tinyurl.com/37dfdenf
🔬 Ready to try HCR™ Gold IF? Get a free Starter Kit here: tinyurl.com/37dfdenf
We can't wait to be at SFN this year! Visit Booth #833, and see how HCR™ technology is empowering researchers to advance discoveries in neuroscience! Come chat with our team, and discover how MI can support your next breakthrough.
November 15, 2025 at 5:02 PM
We can't wait to be at SFN this year! Visit Booth #833, and see how HCR™ technology is empowering researchers to advance discoveries in neuroscience! Come chat with our team, and discover how MI can support your next breakthrough.
🪧 SITC Poster Spotlight
In our final SITC Poster Spotlight, we showcased the newly launched HCR™ HiFi Encoders and their ability to enable rapid, flexible multiplex IF with off-the-shelf antibodies –– no carrier-free or glycerol-free storage media required.
🔬Read more: tinyurl.com/5dn5y4a4
In our final SITC Poster Spotlight, we showcased the newly launched HCR™ HiFi Encoders and their ability to enable rapid, flexible multiplex IF with off-the-shelf antibodies –– no carrier-free or glycerol-free storage media required.
🔬Read more: tinyurl.com/5dn5y4a4
November 13, 2025 at 6:44 PM
🪧 SITC Poster Spotlight
In our final SITC Poster Spotlight, we showcased the newly launched HCR™ HiFi Encoders and their ability to enable rapid, flexible multiplex IF with off-the-shelf antibodies –– no carrier-free or glycerol-free storage media required.
🔬Read more: tinyurl.com/5dn5y4a4
In our final SITC Poster Spotlight, we showcased the newly launched HCR™ HiFi Encoders and their ability to enable rapid, flexible multiplex IF with off-the-shelf antibodies –– no carrier-free or glycerol-free storage media required.
🔬Read more: tinyurl.com/5dn5y4a4
🪧 SITC Poster Spotlight
Our next spotlight establishes an RNA-first translational workflow for diagnostic development with the lateral flow assay. This poster highlights how the HCR™ platform facilitates molecular tracking from discovery to clinical diagnostics.
🔬Read more: tinyurl.com/5dn5y4a4
Our next spotlight establishes an RNA-first translational workflow for diagnostic development with the lateral flow assay. This poster highlights how the HCR™ platform facilitates molecular tracking from discovery to clinical diagnostics.
🔬Read more: tinyurl.com/5dn5y4a4
November 12, 2025 at 8:51 PM
🪧 SITC Poster Spotlight
Our next spotlight establishes an RNA-first translational workflow for diagnostic development with the lateral flow assay. This poster highlights how the HCR™ platform facilitates molecular tracking from discovery to clinical diagnostics.
🔬Read more: tinyurl.com/5dn5y4a4
Our next spotlight establishes an RNA-first translational workflow for diagnostic development with the lateral flow assay. This poster highlights how the HCR™ platform facilitates molecular tracking from discovery to clinical diagnostics.
🔬Read more: tinyurl.com/5dn5y4a4
🪧 SITC Poster Spotlight
Last weekend, we shared how the next-gen HCR™ HiFi Probe architecture enables background-suppressed in situ detection of short RNA targets by integrating full-length HCR™ initiators with a novel background suppression strategy.
🔬Check out the poster: tinyurl.com/5dn5y4a4
Last weekend, we shared how the next-gen HCR™ HiFi Probe architecture enables background-suppressed in situ detection of short RNA targets by integrating full-length HCR™ initiators with a novel background suppression strategy.
🔬Check out the poster: tinyurl.com/5dn5y4a4
November 11, 2025 at 7:31 PM
🪧 SITC Poster Spotlight
Last weekend, we shared how the next-gen HCR™ HiFi Probe architecture enables background-suppressed in situ detection of short RNA targets by integrating full-length HCR™ initiators with a novel background suppression strategy.
🔬Check out the poster: tinyurl.com/5dn5y4a4
Last weekend, we shared how the next-gen HCR™ HiFi Probe architecture enables background-suppressed in situ detection of short RNA targets by integrating full-length HCR™ initiators with a novel background suppression strategy.
🔬Check out the poster: tinyurl.com/5dn5y4a4
#onlywithHCR: Goldman et al. created the Aedes aegypti Mosquito Cell Atlas, revealing novel cell types, the organization of sensory neuron chemoreceptors, and sexually dimorphic gene expression in the antenna and brain.
🦟 Read more: tinyurl.com/2rtk4bz2
🦟 Read more: tinyurl.com/2rtk4bz2
November 7, 2025 at 5:17 PM
#onlywithHCR: Goldman et al. created the Aedes aegypti Mosquito Cell Atlas, revealing novel cell types, the organization of sensory neuron chemoreceptors, and sexually dimorphic gene expression in the antenna and brain.
🦟 Read more: tinyurl.com/2rtk4bz2
🦟 Read more: tinyurl.com/2rtk4bz2
We’re thrilled to be attending #SITC2025 this year! Visit us at Booth #626 and don’t miss our poster presentations, as we’ll be sharing exciting new findings and real-world applications!
🗓️ Friday (Nov 7) — Abstract #171 & Abstract #75
🗓️ Saturday (Nov 8) — Abstract #68
🗓️ Friday (Nov 7) — Abstract #171 & Abstract #75
🗓️ Saturday (Nov 8) — Abstract #68
November 6, 2025 at 5:30 PM
We’re thrilled to be attending #SITC2025 this year! Visit us at Booth #626 and don’t miss our poster presentations, as we’ll be sharing exciting new findings and real-world applications!
🗓️ Friday (Nov 7) — Abstract #171 & Abstract #75
🗓️ Saturday (Nov 8) — Abstract #68
🗓️ Friday (Nov 7) — Abstract #171 & Abstract #75
🗓️ Saturday (Nov 8) — Abstract #68
#BehindMI: Meet Sulan Wu and Adam Maddox, two of the leaders on our Operations Strategy Team, who guide cross-functional coordination, optimize processes, and strengthen product validation. Their work positions MI to support cutting-edge research around the world with speed, reliability, and scale!
November 3, 2025 at 6:01 PM
#BehindMI: Meet Sulan Wu and Adam Maddox, two of the leaders on our Operations Strategy Team, who guide cross-functional coordination, optimize processes, and strengthen product validation. Their work positions MI to support cutting-edge research around the world with speed, reliability, and scale!
Happy Halloween from the MI team! Check out this spooky-themed rat hippocampus image by Jamuna Tandukar using #HCRimaging. 🧠
🟣 Mettl3
⚪️ astrocytes
🟢 nuclei
🟠 rRNA
🟣 Mettl3
⚪️ astrocytes
🟢 nuclei
🟠 rRNA
October 31, 2025 at 5:46 PM
Happy Halloween from the MI team! Check out this spooky-themed rat hippocampus image by Jamuna Tandukar using #HCRimaging. 🧠
🟣 Mettl3
⚪️ astrocytes
🟢 nuclei
🟠 rRNA
🟣 Mettl3
⚪️ astrocytes
🟢 nuclei
🟠 rRNA
#onlywithHCR: Gillis et al. used #HCRtechnology to visualize gene expression during gill slit formation in skate embryos, revealing a precise sequence of epithelial interactions between the endoderm and ectoderm.
🔬 Read more: tinyurl.com/3mvj2wu2
🔬 Read more: tinyurl.com/3mvj2wu2
October 24, 2025 at 4:19 PM
#onlywithHCR: Gillis et al. used #HCRtechnology to visualize gene expression during gill slit formation in skate embryos, revealing a precise sequence of epithelial interactions between the endoderm and ectoderm.
🔬 Read more: tinyurl.com/3mvj2wu2
🔬 Read more: tinyurl.com/3mvj2wu2
Fast. Simple. High-fidelity IF.
The HCR™ HiFi Encoder gives you the power to encode any unmodified primary in just 10 minutes at RT. Use your existing antibodies and achieve high-fidelity multiplex IF with HCR™ Gold.
🔬Place your HCR™ Gold IF order here: tinyurl.com/57f8nmb8
The HCR™ HiFi Encoder gives you the power to encode any unmodified primary in just 10 minutes at RT. Use your existing antibodies and achieve high-fidelity multiplex IF with HCR™ Gold.
🔬Place your HCR™ Gold IF order here: tinyurl.com/57f8nmb8
October 22, 2025 at 5:31 PM
Fast. Simple. High-fidelity IF.
The HCR™ HiFi Encoder gives you the power to encode any unmodified primary in just 10 minutes at RT. Use your existing antibodies and achieve high-fidelity multiplex IF with HCR™ Gold.
🔬Place your HCR™ Gold IF order here: tinyurl.com/57f8nmb8
The HCR™ HiFi Encoder gives you the power to encode any unmodified primary in just 10 minutes at RT. Use your existing antibodies and achieve high-fidelity multiplex IF with HCR™ Gold.
🔬Place your HCR™ Gold IF order here: tinyurl.com/57f8nmb8
We’re proud to partner with Abcam to make multiplex IF simpler, faster, and more flexible! The HCR™ HiFi Encoder offers broad compatibility with Abcam’s primary antibodies, providing HCR™ Gold amplification for the antibodies you already know and trust.
Full press release: tinyurl.com/5a43h8cr
Full press release: tinyurl.com/5a43h8cr
October 21, 2025 at 3:30 PM
We’re proud to partner with Abcam to make multiplex IF simpler, faster, and more flexible! The HCR™ HiFi Encoder offers broad compatibility with Abcam’s primary antibodies, providing HCR™ Gold amplification for the antibodies you already know and trust.
Full press release: tinyurl.com/5a43h8cr
Full press release: tinyurl.com/5a43h8cr
#onlywithHCR: Rajan et al. illuminated how multicellular dynamics shape olfactory neurogenesis in zebrafish. These findings show how coordinated signaling supports ongoing neuron production in a complex organ system.
Read more: tinyurl.com/3tpmf4v3
Read more: tinyurl.com/3tpmf4v3
October 17, 2025 at 4:58 PM
#onlywithHCR: Rajan et al. illuminated how multicellular dynamics shape olfactory neurogenesis in zebrafish. These findings show how coordinated signaling supports ongoing neuron production in a complex organ system.
Read more: tinyurl.com/3tpmf4v3
Read more: tinyurl.com/3tpmf4v3
🚀The HCR™ HiFi Encoder is now live, bringing plug-and-play practicality to multiplex IF.
✅ Multiplex same-species primaries, no cross-reactivity
✅ Encode in 10 min at RT, no affinity loss
✅ Unlock high-fidelity amplification with HCR™ Gold
🛒Order today: tinyurl.com/mr4295e6
✅ Multiplex same-species primaries, no cross-reactivity
✅ Encode in 10 min at RT, no affinity loss
✅ Unlock high-fidelity amplification with HCR™ Gold
🛒Order today: tinyurl.com/mr4295e6
October 13, 2025 at 5:57 PM
🚀The HCR™ HiFi Encoder is now live, bringing plug-and-play practicality to multiplex IF.
✅ Multiplex same-species primaries, no cross-reactivity
✅ Encode in 10 min at RT, no affinity loss
✅ Unlock high-fidelity amplification with HCR™ Gold
🛒Order today: tinyurl.com/mr4295e6
✅ Multiplex same-species primaries, no cross-reactivity
✅ Encode in 10 min at RT, no affinity loss
✅ Unlock high-fidelity amplification with HCR™ Gold
🛒Order today: tinyurl.com/mr4295e6
#onlywithHCR: Romero et al. explored how pathogenic TP53 variants contribute to congenital anomalies of the kidney and urinary tract and genital defects. Using Xenopus embryos, they observed that the expression of mutant TP53 disrupted kidney morphogenesis.
Read more here: tinyurl.com/mr3yfwzy
Read more here: tinyurl.com/mr3yfwzy
October 10, 2025 at 5:23 PM
#onlywithHCR: Romero et al. explored how pathogenic TP53 variants contribute to congenital anomalies of the kidney and urinary tract and genital defects. Using Xenopus embryos, they observed that the expression of mutant TP53 disrupted kidney morphogenesis.
Read more here: tinyurl.com/mr3yfwzy
Read more here: tinyurl.com/mr3yfwzy
Episode 2 of the HCR™ HiFi Encoder series is now live!
This time, we’re walking through the entire encoding protocol from start to finish. See just how easy it is to integrate into your workflow: no purification, no conjugation, only 10 minutes at room temperature.
www.youtube.com/watch?v=1rRJ...
This time, we’re walking through the entire encoding protocol from start to finish. See just how easy it is to integrate into your workflow: no purification, no conjugation, only 10 minutes at room temperature.
www.youtube.com/watch?v=1rRJ...
Episode 2: Understanding the Encoding Workflow
YouTube video by Molecular Instruments
www.youtube.com
October 9, 2025 at 5:17 PM
Episode 2 of the HCR™ HiFi Encoder series is now live!
This time, we’re walking through the entire encoding protocol from start to finish. See just how easy it is to integrate into your workflow: no purification, no conjugation, only 10 minutes at room temperature.
www.youtube.com/watch?v=1rRJ...
This time, we’re walking through the entire encoding protocol from start to finish. See just how easy it is to integrate into your workflow: no purification, no conjugation, only 10 minutes at room temperature.
www.youtube.com/watch?v=1rRJ...
Check out this whole-mount fruit fly image from Dr. Nipam Patel and Saanvi Turki, powered by the HCR™ HiFi Encoder. With the Encoder, you can functionalize any unmodified primary antibody with no purification, no reformulation, and no signal loss.
🔬Pre-order the Launch Edition: tinyurl.com/mr4295e6
🔬Pre-order the Launch Edition: tinyurl.com/mr4295e6
October 8, 2025 at 5:20 PM
Check out this whole-mount fruit fly image from Dr. Nipam Patel and Saanvi Turki, powered by the HCR™ HiFi Encoder. With the Encoder, you can functionalize any unmodified primary antibody with no purification, no reformulation, and no signal loss.
🔬Pre-order the Launch Edition: tinyurl.com/mr4295e6
🔬Pre-order the Launch Edition: tinyurl.com/mr4295e6
#BehindMI: Meet Mohamad and Jawad, two of the software engineers driving MI's digital infrastructure forward. From developing robust software to tackling complex technical challenges, they ensure our digital platform runs seamlessly today and is ready for tomorrow's possibilities.
October 6, 2025 at 6:34 PM
#BehindMI: Meet Mohamad and Jawad, two of the software engineers driving MI's digital infrastructure forward. From developing robust software to tackling complex technical challenges, they ensure our digital platform runs seamlessly today and is ready for tomorrow's possibilities.
#onlywithHCR: Bhandiwad et al. utilized #HCRtechnology to map the neural activity underlying tonic immobility. They found that this outlines a complete sensorimotor circuit, revealing how the brainstem circuit suppresses movement when facing threats.
Read more: tinyurl.com/4dcxhs38
Read more: tinyurl.com/4dcxhs38
September 26, 2025 at 5:27 PM
#onlywithHCR: Bhandiwad et al. utilized #HCRtechnology to map the neural activity underlying tonic immobility. They found that this outlines a complete sensorimotor circuit, revealing how the brainstem circuit suppresses movement when facing threats.
Read more: tinyurl.com/4dcxhs38
Read more: tinyurl.com/4dcxhs38
Stop by Booth #630 and meet the MI team at #2025NSHConvention this weekend!
Join us for a joint workshop with Indica Labs to see how HCR™ Pro and AI-powered HALO image analysis come together to advance RNA and protein co-detection assays.
🗓️ Saturday, September 27th
📍 Workshop #30 at 4:45 PM PST
Join us for a joint workshop with Indica Labs to see how HCR™ Pro and AI-powered HALO image analysis come together to advance RNA and protein co-detection assays.
🗓️ Saturday, September 27th
📍 Workshop #30 at 4:45 PM PST
September 25, 2025 at 4:57 PM
Stop by Booth #630 and meet the MI team at #2025NSHConvention this weekend!
Join us for a joint workshop with Indica Labs to see how HCR™ Pro and AI-powered HALO image analysis come together to advance RNA and protein co-detection assays.
🗓️ Saturday, September 27th
📍 Workshop #30 at 4:45 PM PST
Join us for a joint workshop with Indica Labs to see how HCR™ Pro and AI-powered HALO image analysis come together to advance RNA and protein co-detection assays.
🗓️ Saturday, September 27th
📍 Workshop #30 at 4:45 PM PST
Take a look at this FFPE mouse brain sample showcasing true same-species multiplexing, enabled by the HCR™ HiFi Encoder!
Detect multiple same-species primaries with no cross-reactivity, complex steps, or special workarounds.
🔬 Pre-order the Launch Edition: tinyurl.com/mr4295e6
Detect multiple same-species primaries with no cross-reactivity, complex steps, or special workarounds.
🔬 Pre-order the Launch Edition: tinyurl.com/mr4295e6
September 24, 2025 at 5:58 PM
Take a look at this FFPE mouse brain sample showcasing true same-species multiplexing, enabled by the HCR™ HiFi Encoder!
Detect multiple same-species primaries with no cross-reactivity, complex steps, or special workarounds.
🔬 Pre-order the Launch Edition: tinyurl.com/mr4295e6
Detect multiple same-species primaries with no cross-reactivity, complex steps, or special workarounds.
🔬 Pre-order the Launch Edition: tinyurl.com/mr4295e6
#onlywithHCR: Monroy et al. investigated the timing and localization of key transcription factors during neural crest (NC) development in chicken, quail, and peafowl. They found that quail NC cells initiate expression of SNAI2, SOX9, and SOX10 at earlier stages.
Read more: tinyurl.com/yt4fycah
Read more: tinyurl.com/yt4fycah
September 19, 2025 at 5:06 PM
#onlywithHCR: Monroy et al. investigated the timing and localization of key transcription factors during neural crest (NC) development in chicken, quail, and peafowl. They found that quail NC cells initiate expression of SNAI2, SOX9, and SOX10 at earlier stages.
Read more: tinyurl.com/yt4fycah
Read more: tinyurl.com/yt4fycah
In this premiere episode, we introduce the HCR™ HiFi Encoder – a powerful new tool that lets you rapidly encode any unmodified primary antibody in just minutes.
Say goodbye to fixed antibody panels and hello to true flexibility, fidelity, and freedom in your IF workflow!
tinyurl.com/y53682bk
Say goodbye to fixed antibody panels and hello to true flexibility, fidelity, and freedom in your IF workflow!
tinyurl.com/y53682bk
Episode 1: Unlocking the Future of Multiplex
YouTube video by Molecular Instruments
www.youtube.com
September 18, 2025 at 7:20 PM
In this premiere episode, we introduce the HCR™ HiFi Encoder – a powerful new tool that lets you rapidly encode any unmodified primary antibody in just minutes.
Say goodbye to fixed antibody panels and hello to true flexibility, fidelity, and freedom in your IF workflow!
tinyurl.com/y53682bk
Say goodbye to fixed antibody panels and hello to true flexibility, fidelity, and freedom in your IF workflow!
tinyurl.com/y53682bk