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Molecular Instruments, Inc. @hcrimaging.bsky.social · 20h

Episode 2 of the HCR™ HiFi Encoder series is now live!

This time, we’re walking through the entire encoding protocol from start to finish. See just how easy it is to integrate into your workflow: no purification, no conjugation, only 10 minutes at room temperature.

www.youtube.com/watch?v=1rRJ...

Episode 2: Understanding the Encoding Workflow

YouTube video by Molecular Instruments

www.youtube.com

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Molecular Instruments, Inc. @hcrimaging.bsky.social · 1d

Check out this whole-mount fruit fly image from Dr. Nipam Patel and Saanvi Turki, powered by the HCR™ HiFi Encoder. With the Encoder, you can functionalize any unmodified primary antibody with no purification, no reformulation, and no signal loss.

🔬Pre-order the Launch Edition: tinyurl.com/mr4295e6

Molecular Instruments, Inc. @hcrimaging.bsky.social · 3d

#BehindMI: Meet Mohamad and Jawad, two of the software engineers driving MI's digital infrastructure forward. From developing robust software to tackling complex technical challenges, they ensure our digital platform runs seamlessly today and is ready for tomorrow's possibilities.

Molecular Instruments, Inc. @hcrimaging.bsky.social · 13d

#onlywithHCR: Bhandiwad et al. utilized #HCRtechnology to map the neural activity underlying tonic immobility. They found that this outlines a complete sensorimotor circuit, revealing how the brainstem circuit suppresses movement when facing threats.

Read more: tinyurl.com/4dcxhs38

Molecular Instruments, Inc. @hcrimaging.bsky.social · 14d

Stop by Booth #630 and meet the MI team at #2025NSHConvention this weekend!

Join us for a joint workshop with Indica Labs to see how HCR™ Pro and AI-powered HALO image analysis come together to advance RNA and protein co-detection assays.

🗓️ Saturday, September 27th
📍 Workshop #30 at 4:45 PM PST

Molecular Instruments, Inc. @hcrimaging.bsky.social · 15d

Take a look at this FFPE mouse brain sample showcasing true same-species multiplexing, enabled by the HCR™ HiFi Encoder!

Detect multiple same-species primaries with no cross-reactivity, complex steps, or special workarounds.

🔬 Pre-order the Launch Edition: tinyurl.com/mr4295e6

Molecular Instruments, Inc. @hcrimaging.bsky.social · 20d

#onlywithHCR: Monroy et al. investigated the timing and localization of key transcription factors during neural crest (NC) development in chicken, quail, and peafowl. They found that quail NC cells initiate expression of SNAI2, SOX9, and SOX10 at earlier stages.

Read more: tinyurl.com/yt4fycah

Molecular Instruments, Inc. @hcrimaging.bsky.social · 21d

In this premiere episode, we introduce the HCR™ HiFi Encoder – a powerful new tool that lets you rapidly encode any unmodified primary antibody in just minutes.

Say goodbye to fixed antibody panels and hello to true flexibility, fidelity, and freedom in your IF workflow!

tinyurl.com/y53682bk

Episode 1: Unlocking the Future of Multiplex

YouTube video by Molecular Instruments

www.youtube.com

Molecular Instruments, Inc. @hcrimaging.bsky.social · 24d

📢 Short RNA target detection is now powered by HCR™ Pro RNA-ISH on the Leica Biosystems BOND RX research staining platforms!

Streamline your workflow with HCR™ Pro RNA-ISH automated on the BOND RX, now expanded for a wider range of research applications.

Molecular Instruments, Inc. @hcrimaging.bsky.social · 27d

#onlywithHCR: Sun et al. uncovered a crucial role for Zic5 in Xenopus eye development. Using #HCRtechnology, they showed Zic5 expression in the RPE and NR at the optic vesicle stage, where it helps tune Hedgehog signaling to ensure proper eye development.

Read more: tinyurl.com/mrxru323

Molecular Instruments, Inc. @hcrimaging.bsky.social · 28d

We're excited to announce the HCR™ HiFi Encoder, a breakthrough advancement that delivers robust amplification for any primary antibody and enables same-species multiplex immunofluorescence!

Read the full PR: tinyurl.com/2ctxx5d6

Pre-order Launch Edition bundles: tinyurl.com/mr4295e6

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Molecular Instruments, Inc. @hcrimaging.bsky.social · Sep 9

#BehindMI: Meet some of the members of our Admin team, powering the engine behind the scenes at MI, bringing both our goals and your orders to life.

From processing purchase orders to keeping records up to date, they ensure our mission runs smoothly and the HCR™ community stays fully supported!

Molecular Instruments, Inc. @hcrimaging.bsky.social · Sep 8

Submissions for the 3D Imaging World Cup close tonight!

This is your last chance to share your best light-sheet images—new or previously published—and compete for prizes. We’re blown away by the incredible submissions so far!

Submit your entries here: tinyurl.com/mr3ct9f8

Molecular Instruments, Inc. @hcrimaging.bsky.social · Sep 5

#onlywithHCR: Busby et al. utilized #HCRtechnology to track gene expression during chicken somitogenesis. They revealed a stalled cell state linked to Hox genes, indicating that developmental timing is set intrinsically but can also be influenced by extrinsic cues.

Read more: tinyurl.com/pxs5jrcu

Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 29

#onlywithHCR: Janesick et al. created an RNA-seq atlas of the chicken cochlea, revealing regenerative insights. Using #HCRtechnology to validate gene expression, they found tonotopic gradients along the cochlea, setting up the stage for comparative studies.

Read more: tinyurl.com/2t7zhfwn

Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 26

It’s official—we’re two weeks away from the Final Whistle for the 3D Imaging World Cup!

Thank you for your amazing light-sheet submissions, and we can’t wait to see what stunning images come in during this final stretch.

Enter your submission here: www.alpenglowbiosciences.com/3d-imaging-w...

Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 22

#onlywithHCR: With #HCRtechnology, Witch et al. revealed that salamander brain comparisons point to the DVR and neocortex evolving through convergence, while the mammalian olfactory-entorhinal-hippocampal circuit may trace back to ancestral origins.

Read more: tinyurl.com/4bwm599u

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Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 20

What an amazing time at West Coast SDB in SLO!

Huge thanks to everyone who joined us at Cal Poly to hear our CCO, Dr. Aneesh Acharya, unveil exciting updates to the HCR™ platform.

It was a pleasure connecting with the dev bio community and seeing the enthusiasm surrounding the future of MI!

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Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 15

#onlywithHCR: Treen et al. pinpointed two Prdm1 homologs as the earliest FGF-responsive genes. By combining #HCRtechnology with genetic and experimental manipulations, they found a sharp developmental transition between the 8- and 16-cell stages.

Read more: genesdev.cshlp.org/content/37/3...

Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 14

We're thrilled to be at the 2025 SDB West Coast Meeting tomorrow! Join Dr. Acharya as he shares exciting updates on the HCR™ platform.

📍Cal Poly SLO
🗓️ Friday, 8/15 | 2:00–2:45 PM

We’re looking forward to connecting with the dev bio community. Don’t miss your chance to grab limited-edition merch!

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Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 8

#onlywithHCR: Kim et al. dissected how human pyramidal neurons connect to inhibitory interneurons in a cell type-specific manner. Using #HCRtechnology to confirm cell types and gene expression, they discovered conserved synaptic motifs in human brain circuits.

Read more: tinyurl.com/4nrsm275

Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 7

The countdown is on for the 3D Imaging World Cup 2025! Don’t miss your chance to share your best light-sheet images—new or previously published—and compete for prizes.

💡Early submissions by August 8th will earn an extra 50 bonus points!

Submit your entry here: tinyurl.com/mr3ct9f8

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Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 7

The countdown is on for the 3D Imaging World Cup 2025! Don’t miss your chance to share your best light-sheet images—new or previously published—and compete for prizes.

💡Early submissions by August 8th will earn an extra 50 bonus points!

Submit your entry here: tinyurl.com/mr3ct9f8

Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 4

#BehindMI: Meet Wudy Yang, Jacob Prohroff, Randy Chen, and Alexandra Delgadillo — the team driving innovation at MI. Driven by curiosity and grounded in scientific rigor, their work ensures that HCR™ technology remains a trusted tool for researchers, enabling precise and efficient discovery.

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Molecular Instruments, Inc. @hcrimaging.bsky.social · Aug 1

#onlywithHCR: Lin et al. mapped ~500K nuclei across 19 CNS regions in marmoset to chart glial diversity.

With #HCRtechnology, they visualized key gene expression patterns in OLIG2+ cells, revealing transcriptional shifts in white matter glia within a 3D context.

Read more: tinyurl.com/bdfadjnr