@hsiehyp.bsky.social
Reposted
Our annual PhD call is closing at the end of this week on 30 November. If you're interested in carrying out world-class scientific research in Barcelona, you still have a few days left to submit your application! www.crg.eu/en/content/t...
November 25, 2025 at 7:43 AM
Our annual PhD call is closing at the end of this week on 30 November. If you're interested in carrying out world-class scientific research in Barcelona, you still have a few days left to submit your application! www.crg.eu/en/content/t...
Reposted
Really cool paper from @vincentdebakker.bsky.social @jonbakerlab.bsky.social now published @natcomms.nature.com #MicroSky www.nature.com/articles/s41...
Multi-omics profiling reveals atypical sugar utilization and a key membrane composition regulator in Streptococcus pneumoniae - Nature Communications
The pathogen Streptococcus pneumoniae can adapt to diverse microenvironments in the human body. Here, De Bakker et al. study these adaptation responses, showing unusual sugar utilization and identifyi...
www.nature.com
November 25, 2025 at 1:44 PM
Really cool paper from @vincentdebakker.bsky.social @jonbakerlab.bsky.social now published @natcomms.nature.com #MicroSky www.nature.com/articles/s41...
Reposted
Really pleased to share the first paper to come out of the lab.
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
High frequency body site translocation of nosocomial Pseudomonas aeruginosa - Nature Communications
Here, the authors report within-host diversity and body site translocation dynamics in hospital samples of Pseudomonas aeruginosa and reveal that body site sharing was likely due to within-patient tra...
www.nature.com
November 25, 2025 at 10:40 AM
Really pleased to share the first paper to come out of the lab.
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
Reposted
The ecological roles of bacterial #immune systems are poorly understood. Rafael Custodio @ellinoralseth.bsky.social @brockhurstlab.bsky.social @brownlab.bsky.social & Edze Westra explore how mobile genetic elements and bacterial defenses shape #microbiome structure and function 🧪
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic…
plos.io
November 24, 2025 at 5:30 PM
The ecological roles of bacterial #immune systems are poorly understood. Rafael Custodio @ellinoralseth.bsky.social @brockhurstlab.bsky.social @brownlab.bsky.social & Edze Westra explore how mobile genetic elements and bacterial defenses shape #microbiome structure and function 🧪
Reposted
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp 🦠🤯
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp | mBio
Alarmone synthetases are intracellular enzymes that promote bacterial survival by
responding to environmental stress. Although extracellular alarmone production has
been reported in Streptomyces, the ...
journals.asm.org
November 15, 2025 at 12:42 PM
Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp 🦠🤯
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
Reposted
We're hiring! My dept. is looking for a candidate with a research program focusing on plant systems. All areas of molecular and cellular biology research will be considered. Not sure if you'd fit? Reach out to me. Please share! #microsky
November 17, 2025 at 6:18 PM
We're hiring! My dept. is looking for a candidate with a research program focusing on plant systems. All areas of molecular and cellular biology research will be considered. Not sure if you'd fit? Reach out to me. Please share! #microsky
Reposted
Deeply saddened by the passing of my colleague, Prof. Meng-Chao Yao, a remarkable scientist and mentor. He left an indelible mark on all of us fortunate enough to know him. His legacy in molecular and ciliate biology will endure. Rest well, my friend. 1/
obituaries.seattletimes.com/obituary/men...
obituaries.seattletimes.com/obituary/men...
Meng-Chao Yao Obituary | 1949 - 2025 | Seattle Times
View Meng-Chao Yao's complete obituary, share memories, and explore 1 tribute posts from the community.
obituaries.seattletimes.com
November 17, 2025 at 11:24 PM
Deeply saddened by the passing of my colleague, Prof. Meng-Chao Yao, a remarkable scientist and mentor. He left an indelible mark on all of us fortunate enough to know him. His legacy in molecular and ciliate biology will endure. Rest well, my friend. 1/
obituaries.seattletimes.com/obituary/men...
obituaries.seattletimes.com/obituary/men...
Reposted
New in JB: Black and Wakeman review the challenges of treating polymicrobial infections in various body sites, a topic near and dear to my heart.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 23, 2025 at 12:20 PM
New in JB: Black and Wakeman review the challenges of treating polymicrobial infections in various body sites, a topic near and dear to my heart.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted
New lab paper!
Andrew Frando describes how MexT alters the quorum sensing cascade in P. aeruginosa. /1
With Nicole Smalley; two undergraduates, Jamal Omar and Bobby Parsek; and @dezieleric.bsky.social, @mariecg.bsky.social, and Mylène Trottier at INRS in Montreal
journals.asm.org/doi/10.1128/...
Andrew Frando describes how MexT alters the quorum sensing cascade in P. aeruginosa. /1
With Nicole Smalley; two undergraduates, Jamal Omar and Bobby Parsek; and @dezieleric.bsky.social, @mariecg.bsky.social, and Mylène Trottier at INRS in Montreal
journals.asm.org/doi/10.1128/...
Modulation of the Pseudomonas aeruginosa quorum sensing cascade by MexT-regulated factors | mBio
Bacteria interact with both abiotic and biotic factors in their environment. Quorum
sensing (QS) is one mechanism that bacteria use to communicate with other bacteria
and coordinate behaviors in the p...
journals.asm.org
October 23, 2025 at 5:52 PM
New lab paper!
Andrew Frando describes how MexT alters the quorum sensing cascade in P. aeruginosa. /1
With Nicole Smalley; two undergraduates, Jamal Omar and Bobby Parsek; and @dezieleric.bsky.social, @mariecg.bsky.social, and Mylène Trottier at INRS in Montreal
journals.asm.org/doi/10.1128/...
Andrew Frando describes how MexT alters the quorum sensing cascade in P. aeruginosa. /1
With Nicole Smalley; two undergraduates, Jamal Omar and Bobby Parsek; and @dezieleric.bsky.social, @mariecg.bsky.social, and Mylène Trottier at INRS in Montreal
journals.asm.org/doi/10.1128/...
Reposted
This book has never been more timely. Thanks to @sonali-m-19.bsky.social for writing it and for sending me a copy.
October 10, 2025 at 8:16 PM
This book has never been more timely. Thanks to @sonali-m-19.bsky.social for writing it and for sending me a copy.
Reposted
I hard co-sign this one.
October 7, 2025 at 2:11 AM
I hard co-sign this one.
Reposted
Finally out, such an awesome piece of work, very proud of this one: www.cell.com/cell-systems... #MicroSky
October 4, 2025 at 8:48 AM
Finally out, such an awesome piece of work, very proud of this one: www.cell.com/cell-systems... #MicroSky
Reposted
New preprint alert! 🦟 <-> 🦠 <-> 🧑
I am thrilled to share our latest study on alphavirus host adaptation. More specifically, on how a single codon helps blunt alphavirus-induced host innate immune responses in mosquito and human cells. Continue reading for more!
www.biorxiv.org/content/10.1...
I am thrilled to share our latest study on alphavirus host adaptation. More specifically, on how a single codon helps blunt alphavirus-induced host innate immune responses in mosquito and human cells. Continue reading for more!
www.biorxiv.org/content/10.1...
The Sindbis virus nsP3 opal codon protects viral RNA and fitness by maintaining replication spherule integrity
Most alphaviruses encode an in-frame opal stop codon between nsP3 and nsP4 in their nsP ORF. This opal stop codon mediates a temperature-dependent balance between viral polymerase production and prote...
www.biorxiv.org
September 29, 2025 at 11:23 AM
New preprint alert! 🦟 <-> 🦠 <-> 🧑
I am thrilled to share our latest study on alphavirus host adaptation. More specifically, on how a single codon helps blunt alphavirus-induced host innate immune responses in mosquito and human cells. Continue reading for more!
www.biorxiv.org/content/10.1...
I am thrilled to share our latest study on alphavirus host adaptation. More specifically, on how a single codon helps blunt alphavirus-induced host innate immune responses in mosquito and human cells. Continue reading for more!
www.biorxiv.org/content/10.1...
Reposted
Pitt is an absolutely amazing place for microbiology, particularly evolutionary microbiology. And they’re hiring!
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine.
1) Fundamental researc...
www.linkedin.com
September 24, 2025 at 12:10 AM
Pitt is an absolutely amazing place for microbiology, particularly evolutionary microbiology. And they’re hiring!
Reposted
🎙️ ALBA-IBRO Diversity Podcast: From Postdoc to PI.
Ep.5 - Redefining success: choosing your compass in academia
🔗 youtu.be/wfIu0ahjpuM
🗣️ Hosts @lonelypipette.bsky.social
👥 Rachael Dangarembizi, Michaela Fenckova, @harmitmalik.bsky.social & @srikipedia.bsky.social
🌟 Supported by @ibroorg.bsky.social
Ep.5 - Redefining success: choosing your compass in academia
🔗 youtu.be/wfIu0ahjpuM
🗣️ Hosts @lonelypipette.bsky.social
👥 Rachael Dangarembizi, Michaela Fenckova, @harmitmalik.bsky.social & @srikipedia.bsky.social
🌟 Supported by @ibroorg.bsky.social
ALBA-IBRO Diversity Podcast - Ep.5 - Redefining success: choosing your compass in academia
YouTube video by ALBA Network
youtu.be
September 18, 2025 at 3:42 PM
🎙️ ALBA-IBRO Diversity Podcast: From Postdoc to PI.
Ep.5 - Redefining success: choosing your compass in academia
🔗 youtu.be/wfIu0ahjpuM
🗣️ Hosts @lonelypipette.bsky.social
👥 Rachael Dangarembizi, Michaela Fenckova, @harmitmalik.bsky.social & @srikipedia.bsky.social
🌟 Supported by @ibroorg.bsky.social
Ep.5 - Redefining success: choosing your compass in academia
🔗 youtu.be/wfIu0ahjpuM
🗣️ Hosts @lonelypipette.bsky.social
👥 Rachael Dangarembizi, Michaela Fenckova, @harmitmalik.bsky.social & @srikipedia.bsky.social
🌟 Supported by @ibroorg.bsky.social
Reposted
September 20, 2025 at 7:08 PM
Reposted
New lab preprint! We set out to explore interstrain differences in P. aeruginosa cooperation and discovered an interesting variant of the quorum sensing receptor LasR. — by Kiki Bellamoroso, Maxim Kostylev, and Nicole Smalley
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Inactivation of MexT in Pseudomonas aeruginosa destabilizes cooperation and favors the emergence of a unique quorum sensing variant
Pseudomonas aeruginosa , an opportunistic gram-negative pathogen, uses a cell-cell signaling system called quorum sensing to coordinate group behaviors. Quorum sensing in P. aeruginosa is a model to s...
www.biorxiv.org
September 20, 2025 at 3:28 PM
New lab preprint! We set out to explore interstrain differences in P. aeruginosa cooperation and discovered an interesting variant of the quorum sensing receptor LasR. — by Kiki Bellamoroso, Maxim Kostylev, and Nicole Smalley
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
We're hiring! 5 tenure track assistant professors. 2 #microbiology, 2 #Evolution, 1 #biologicalclocks
jobs.sciencecareers.org/job/675062/f...
jobs.sciencecareers.org/job/675062/f...
Five Tenure-Track Assistant Professor Positions in Microbiology, Evolution, and Biological Clocks - College Station, Texas job with Department of Biology - TAMU | 675062
Texas A&M University (TAMU) invites applications for five full-time, tenure-track Assistant Professor positions
jobs.sciencecareers.org
September 12, 2025 at 6:11 PM
We're hiring! 5 tenure track assistant professors. 2 #microbiology, 2 #Evolution, 1 #biologicalclocks
jobs.sciencecareers.org/job/675062/f...
jobs.sciencecareers.org/job/675062/f...
Reposted
My new favorite T-shirt
(Courtesy outgoing postdocs @ching-hochang.bsky.social & @hsiehyp.bsky.social)
(Courtesy outgoing postdocs @ching-hochang.bsky.social & @hsiehyp.bsky.social)
September 6, 2025 at 8:51 PM
My new favorite T-shirt
(Courtesy outgoing postdocs @ching-hochang.bsky.social & @hsiehyp.bsky.social)
(Courtesy outgoing postdocs @ching-hochang.bsky.social & @hsiehyp.bsky.social)
Reposted
We have a position for an Assist Prof in Microbial Genomics in our School of III.
Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it
www.jobs.ac.uk/job/DOO184/a...
Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it
www.jobs.ac.uk/job/DOO184/a...
Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham
Apply now for the Assistant Professor (Research and Education) in Bacterial Genomics role on jobs.ac.uk - the leading job board for higher education jobs. View details.
www.jobs.ac.uk
September 3, 2025 at 4:02 PM
We have a position for an Assist Prof in Microbial Genomics in our School of III.
Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it
www.jobs.ac.uk/job/DOO184/a...
Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it
www.jobs.ac.uk/job/DOO184/a...
Reposted
More foundations should do this:
"Funding is exclusively available to applicants who have already received federal funding (e.g., from the NIH, CDC, NSF) for their health equity research, but have since had their funding rescinded due to federal administrative actions"
www.rwjf.org/en/grants/ac...
"Funding is exclusively available to applicants who have already received federal funding (e.g., from the NIH, CDC, NSF) for their health equity research, but have since had their funding rescinded due to federal administrative actions"
www.rwjf.org/en/grants/ac...
Rapid Response: Reinvesting in Racial and Indigenous Health Equity Research
The purpose of this call for proposals is to meet the current moment by supporting timely, actionable health equity research that has been interrupted by shifts in federal funding.
www.rwjf.org
August 30, 2025 at 8:58 PM
More foundations should do this:
"Funding is exclusively available to applicants who have already received federal funding (e.g., from the NIH, CDC, NSF) for their health equity research, but have since had their funding rescinded due to federal administrative actions"
www.rwjf.org/en/grants/ac...
"Funding is exclusively available to applicants who have already received federal funding (e.g., from the NIH, CDC, NSF) for their health equity research, but have since had their funding rescinded due to federal administrative actions"
www.rwjf.org/en/grants/ac...
Reposted
The CDC shaped my career and saved countless lives around the world. To see it hollowed out and replaced by ideology is devastating. In my latest essay, I share my own CDC story and why its unraveling matters for all of us.
open.substack.com/pub/bktitanj...
open.substack.com/pub/bktitanj...
What Becomes of the CDC Now?
From shaping global health policy to guiding my own path in medicine, the CDC’s legacy is too important to abandon.
open.substack.com
August 29, 2025 at 11:06 PM
The CDC shaped my career and saved countless lives around the world. To see it hollowed out and replaced by ideology is devastating. In my latest essay, I share my own CDC story and why its unraveling matters for all of us.
open.substack.com/pub/bktitanj...
open.substack.com/pub/bktitanj...
Reposted
Very interesting paper!
We actually discussed your paper on our paper where we originally evolved the parasite lines (👇). Tho the experimental settings differed from urs :)
journals.plos.org/plospathogen...
We actually discussed your paper on our paper where we originally evolved the parasite lines (👇). Tho the experimental settings differed from urs :)
journals.plos.org/plospathogen...
Complex interactions in the life cycle of a simple parasite shape the evolution of virulence
Author summary Classical expectations on parasite evolution assume a trade-off between transmission rate and harm to the host (virulence), favoring parasites with intermediate virulence. However, rece...
journals.plos.org
August 29, 2025 at 12:02 PM
Very interesting paper!
We actually discussed your paper on our paper where we originally evolved the parasite lines (👇). Tho the experimental settings differed from urs :)
journals.plos.org/plospathogen...
We actually discussed your paper on our paper where we originally evolved the parasite lines (👇). Tho the experimental settings differed from urs :)
journals.plos.org/plospathogen...
Reposted
New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards.
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes
Background Variation within the prokaryotic pangenome is not random, and natural selection that favours particular combinations of genes appears to dominate over random drift. What is less clear is wh...
www.biorxiv.org
August 29, 2025 at 2:05 PM
New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards.
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...