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huiqingzhou.bsky.social
Huiqing Zhou
@huiqingzhou.bsky.social
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huiqingzhou.bsky.social
Huiqing Zhou @huiqingzhou.bsky.social · May 16
Happy to share a paper from our group on "MapID-tRNA-seq" for confidently identifying modifications by RT mutation signatures in human tRNAs. This method will enable future discoveries of modifications' occurrence and functions in tRNA biology and diseases. www.cell.com/cell-chemica...
MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA
tRNA chemical modifications play critical roles in biology and diseases. Tepe et al. report MapID-tRNA-seq to map m1A, m3C, and multiple bulky modifications in tRNAs from HEK293T and breast cancer-rel...
www.cell.com
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huiqingzhou.bsky.social
Huiqing Zhou @huiqingzhou.bsky.social · May 16
If one aims to specifically look at mods changes at a known mod site in tRNAs, other tRNA-seq methods work well for this purpose. If one looks to broadly profile mod sites in tRNAs, MapID-tRNA-seq provides unique analytical power to rule out miscallings.
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huiqingzhou.bsky.social
Huiqing Zhou @huiqingzhou.bsky.social · May 16
Great point! A major challenge with calling modification sites by RT mutation signatures is that there are high chances of miscalling due to apparent mutations resulted from tRNA genetic variances in humans. MapIDs provide a bioinformatics solution to these miscallings.
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huiqingzhou.bsky.social
Huiqing Zhou @huiqingzhou.bsky.social · May 16
A follow-up interview with the editor @cp-cellchembiol.bsky.social to share our journeys and perspectives, along with our recent paper on MapID-tRNA-seq.
cp-cellchembiol.bsky.social
Cell Chemical Biology @cp-cellchembiol.bsky.social · May 15
Meet the authors: Mitchel L. Tepe and Huiqing Zhou
In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the authors of the Resource entitled “MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA” share their perspectives on their field and life as scientists.
dlvr.it
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huiqingzhou.bsky.social
Huiqing Zhou @huiqingzhou.bsky.social · May 16
Happy to share a paper from our group on "MapID-tRNA-seq" for confidently identifying modifications by RT mutation signatures in human tRNAs. This method will enable future discoveries of modifications' occurrence and functions in tRNA biology and diseases. www.cell.com/cell-chemica...
MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA
tRNA chemical modifications play critical roles in biology and diseases. Tepe et al. report MapID-tRNA-seq to map m1A, m3C, and multiple bulky modifications in tRNAs from HEK293T and breast cancer-rel...
www.cell.com
1 4 20