Anesthesia & Analgesia
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ANESTHESIA & ANALGESIA, the official journal of the International Anesthesia Research Society, is “The Global Standard in Anesthesiology," and provides practice-oriented, ​pre-clinical and clinical research needed to provide optimal care to your patients.
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Editorial "Bridging the Gap: The Challenge of Conducting Clinical Trials in Sub-Saharan Africa "

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Anesthesiologists must advocate for sustainable investments in research capacity, infrastructure, & training while fostering collaborative partnerships
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🌍 The review identified limitations such as small sample sizes, under-representation of high surgical burden disciplines, &poor reporting of outcomes. The clinical trial capacity is limited to a few countries/institutions, and quality remains poor

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Check out the editorial "Opioid Preconditioning in Heart Failure: New Frontier or Old Dog?" from Drs. Obal and Liu

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By advancing understanding of morphine’s protective mechanisms in the failing heart, the door is opened to novel therapeutic approaches
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🫀Delta-opioid receptor protein levels increased in failing hearts of humans& rats. Blocking cardiac DOR selectively reduced morphine-induced cardio protection by inhibiting the Janus kinase signal transducer and activator of the transcription-3 pathway

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Considering applying for the IARS International Outreach Travel Grant? 1 week to register for our upcoming webinar on October 16, 2025, at 9 am ET. Get expert advice on strong abstracts & competitive applications. Info: buff.ly/9DTzcXy #ResearchOpportunity @wfsa.bsky.social @iars360.bsky.social
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Unique Perioperative Medicine Education Programs Designed to Fill Gaps in Postgraduate Medical Education

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The Distinguished Fellow of Perioperative Medicine and the Perioperative Medicine Core Knowledge Certificate combine critical topics for POM
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Don't miss the editorial from Drs. Hepner, O'Glasser, and Vetter on "Education and Training in Perioperative Medicine: Current Versus Ideal Future State"

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#MedEd #PerioperativeMedicine
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Development of a Standardized Perioperative Medicine Fellowship Curriculum

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ASA ad hoc committee identified and defined a standardized set of competencies and content to incorporate into #PerioperativeMedicine fellowship programs for anesthesiologists in US
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Don't miss our October 2025 Issue Video Summary!

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The video summarizes three featured articles from this month's issue of A&A
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Anesthesia & Analgesia welcomes the newest Editorial Fellows, who began August 2025. This 12-month program provides immersive editorial training through Section Editor mentorship, manuscript review, and a scholarly project guided by the journal’s leadership. buff.ly/UC0dRa7@iars...
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🫗 Gastric emptying, assessed with the paracetamol absorption test with greater area under the curve representing faster gastric emptying, did not differ significantly between sugammadex vs neostigmine/glycopyrrolate.

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💉In adjusted analyses, administration of nondepolarizing neuromuscular blocking agents (ND-NMBAs) was dose-dependently associated with a higher risk of postoperative delirium, which was eliminated by reversal agent administration (neostigmine or sugammadex).

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💪Myosteatosis (low skeletal muscle radiodensity) is associated with a significantly increased odds of postoperative complications, especially severe postoperative complications (Clavien-Dindo grade ≥3) in patients undergoing colorectal tumor resection surgery

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🤰A multilabel neural network model was trained to predict the occurrence of cardiovascular morbidity in people with hypertensive disorders of pregnancy during the delivery hospitalization and within 1 year of delivery.

#OBAnes #Maternalmortality #Preeclampsia

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✅Meta-analysis found that both xenon and argon had significant neuroprotective efficacies.
✅ The summary effect for argon was greater than that of xenon
✅ Results support further investigation of xenon and argon as neuroprotective treatments for HIE

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⚠️Rapid practice guideline panel recommended:
1️⃣ Avoid using ketamine as monotherapy analgo-sedation in critically ill adults on iMV
2️⃣ Use #ketamine as an adjunct to non-ketamine usual care sedatives or continue w/ non-ketamine sedatives alone.

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Don't miss "Harnessing the Second Power of Anesthesia for Disorders of Consciousness: 2025 T. H. Seldon Memorial Lecture" by Dr. Stefanie Blain-Moraes

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Check out this interesting perspective "Presidential Anesthetics and the 25th Amendment"

🗽 To improve Presidential health care, anesthetics, & public confidence, it is time to include anesthesiologists in planning the perioperative care of the POTUS.

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"Improving Alarms and Alerts for the Next Generation of Medical Devices"

⏰The article discusses the challenges presented by current medical alarms and propose a comprehensive vision for the next generation of medical equipment.

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Don't miss: "Impact of Skin Pigmentation on Light-Based Medical Devices: Current State & Future Directions for Inclusive Technology"

➡️The integration of technologies in medical practice has improved #patientsafety but potential bias is important area for growth

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Discover the editorial "Unraveling Insulin Resistance Mechanisms During Cardiopulmonary Bypass" by Drs. Zakaria et al.

A new study demonstrated hemolysis may contribute to insulin degradation during CPB challenging conventional understanding of insulin resistance

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💉 Are the changes in insulin concentrations in an extracorporeal circulation circuit (ECC) related to surface adhesion or insulin degradation during CBP?

💉 Results favor insulin degradation by hemolysis rather than insulin adhesion to the ECC surfaces.

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👉 A retrospective study of 60,595 adults who had undergone cancer-related surgeries under anesthesia, patient race or ethnicity was associated w/ antiemetic administration in the preoperative holding area, in the operating room, and in the recovery room.

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🟦 A retrospective study of 33 patients in eleven medical centers demonstrated that placing a morphine pump into the prepontine cistern could effectively alleviate refractory craniofacial cancer pain with few adverse events.

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Check out this featured editorial "Fibrinogen Supplementation in Neonates Undergoing Cardiac Surgery: Looking Beyond Concentration Alone" by Drs. David Faraoni and James DiNardo

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