Ian Dworkin
@idworkin.bsky.social
Evolutionary biologist in love with morphology, especially size and shape. Drosophila Quantitative/Statistical geneticist. Dabbler in Development. Occasional genomicist.
Thinking about cell size a lot lately.
Lab website: https://dworkinlab.github.io
Thinking about cell size a lot lately.
Lab website: https://dworkinlab.github.io
Reposted by Ian Dworkin
Part of the undergrad Cell/Developmental Biology lab, waiting for the first group of students to arrive and generate their own GAL4 enhancer traps yesterday.... the results of their labours at the end of the day... and a whale keeping its beady eye on me during a short lunch break at the Whale Cafe.
November 8, 2025 at 11:38 AM
Part of the undergrad Cell/Developmental Biology lab, waiting for the first group of students to arrive and generate their own GAL4 enhancer traps yesterday.... the results of their labours at the end of the day... and a whale keeping its beady eye on me during a short lunch break at the Whale Cafe.
Reposted by Ian Dworkin
Editor's Choice article in our latest issue:
"The genetic basis of natural variation in sociability " by Arteen Torabi-Marashi, Dania Daanish, Andrew M Scott, Reuven Dukas, & Ian Dworkin.
academic.oup.com/evolut/artic...
@idworkin.bsky.social
"The genetic basis of natural variation in sociability " by Arteen Torabi-Marashi, Dania Daanish, Andrew M Scott, Reuven Dukas, & Ian Dworkin.
academic.oup.com/evolut/artic...
@idworkin.bsky.social
The genetic basis of natural variation in sociability
Abstract. Sociability, defined as individuals’ tendencies to affiliate with conspecifics, is widespread among animals, including species not traditionally
academic.oup.com
October 20, 2025 at 10:36 AM
Editor's Choice article in our latest issue:
"The genetic basis of natural variation in sociability " by Arteen Torabi-Marashi, Dania Daanish, Andrew M Scott, Reuven Dukas, & Ian Dworkin.
academic.oup.com/evolut/artic...
@idworkin.bsky.social
"The genetic basis of natural variation in sociability " by Arteen Torabi-Marashi, Dania Daanish, Andrew M Scott, Reuven Dukas, & Ian Dworkin.
academic.oup.com/evolut/artic...
@idworkin.bsky.social
Reposted by Ian Dworkin
Distinct genomic architectures but the same gene underlie the convergent evolution of a plant supergene https://www.biorxiv.org/content/10.1101/2025.10.01.679701v1
October 1, 2025 at 11:32 PM
Distinct genomic architectures but the same gene underlie the convergent evolution of a plant supergene https://www.biorxiv.org/content/10.1101/2025.10.01.679701v1
Reposted by Ian Dworkin
Fischer et al. characterize differences in gene network connectivity and density, suggesting that flexibility in gene coexpression relationships could promote evolvability.
🔗 doi.org/10.1093/molbev/msaf194
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf194
#evobio #molbio
Flexibility in Gene Coexpression at Developmental and Evolutionary Timescales
Abstract. The explosion of next-generation sequencing technologies has allowed researchers to move from studying single genes to studying thousands of gene
doi.org
October 2, 2025 at 8:51 AM
Fischer et al. characterize differences in gene network connectivity and density, suggesting that flexibility in gene coexpression relationships could promote evolvability.
🔗 doi.org/10.1093/molbev/msaf194
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf194
#evobio #molbio
Reposted by Ian Dworkin
Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations of Drosophila melanogaster
#Drosophila
#Drosophila
Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations of Drosophila melanogaster
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
September 22, 2025 at 5:24 PM
Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations of Drosophila melanogaster
#Drosophila
#Drosophila
Reposted by Ian Dworkin
Brubaker et al. investigated the role of redundancy in cis-regulatory evolution in sexually dimorphic abdomen pigmentation of Drosophila melanogaster.
🔗 doi.org/10.1093/molb...
#evobio #molbio #drosophila
🔗 doi.org/10.1093/molb...
#evobio #molbio #drosophila
Redundant and Singular Regulatory Elements Underlie the Rapidly Evolving Pigmentation of Drosophila
Abstract. A major hurdle in understanding the molecular changes responsible for metazoan diversity is the characterization of cis-regulatory elements (CREs
doi.org
September 22, 2025 at 8:53 AM
Brubaker et al. investigated the role of redundancy in cis-regulatory evolution in sexually dimorphic abdomen pigmentation of Drosophila melanogaster.
🔗 doi.org/10.1093/molb...
#evobio #molbio #drosophila
🔗 doi.org/10.1093/molb...
#evobio #molbio #drosophila
Reposted by Ian Dworkin
Heitzmann et al. compared brain transcriptomes of four sexual genotypes of the African pygmy mouse, showing how sex and neo-sex chromosomes impacted transcriptomes to reflect their transmission mode, evolutionary trajectories, and genomic conflicts.
🔗 doi.org/10.1093/molbev/msaf208
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf208
#evobio #molbio
September 23, 2025 at 9:15 AM
Heitzmann et al. compared brain transcriptomes of four sexual genotypes of the African pygmy mouse, showing how sex and neo-sex chromosomes impacted transcriptomes to reflect their transmission mode, evolutionary trajectories, and genomic conflicts.
🔗 doi.org/10.1093/molbev/msaf208
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf208
#evobio #molbio
Reposted by Ian Dworkin
![Comic. [block quote] “Far better an approximate answer to the *right* question, which is often vague, than an *exact* answer to the wrong question, which can always be made precise.” -John W. Tukey, The Future of Data Analysis (1962) [caption] Happy Approximate Birthday to John Tukey, author of my favorite statistics quote, who was born 110.000 years ago sometime this week.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreid4vie3df7ltmh7capumhhqcpbejyr7ya7y762fasdeq46ud3gyva@jpeg)
Reposted by Ian Dworkin
@jcbnunez.bsky.social et al. present an expanded release of the community-generated resource Drosophila Evolution over Space and Time (DEST 2.0), and showcase it by studying the species' demographic history and signatures of adaptation.
🔗 doi.org/10.1093/molbev/msaf132
#evobio #molbio #drosophila
🔗 doi.org/10.1093/molbev/msaf132
#evobio #molbio #drosophila
August 20, 2025 at 5:52 PM
@jcbnunez.bsky.social et al. present an expanded release of the community-generated resource Drosophila Evolution over Space and Time (DEST 2.0), and showcase it by studying the species' demographic history and signatures of adaptation.
🔗 doi.org/10.1093/molbev/msaf132
#evobio #molbio #drosophila
🔗 doi.org/10.1093/molbev/msaf132
#evobio #molbio #drosophila
Reposted by Ian Dworkin
doi.org/10.1093/molb...
Thrilled to share our new paper in MBE! 🎉 Presenting DEST 2.0: 530 pooled Drosophila populations spanning 12 years across 6 continents. We map genomic footprints of adaptation, from pesticide resistance to seasonal changes. #PopulationGenetics #Drosophila #Genomics #Evolution
Thrilled to share our new paper in MBE! 🎉 Presenting DEST 2.0: 530 pooled Drosophila populations spanning 12 years across 6 continents. We map genomic footprints of adaptation, from pesticide resistance to seasonal changes. #PopulationGenetics #Drosophila #Genomics #Evolution
Footprints of Worldwide Adaptation in Structured Populations of Drosophila melanogaster Through the Expanded DEST 2.0 Genomic Resource
Abstract. Large-scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population g
doi.org
August 19, 2025 at 1:34 AM
doi.org/10.1093/molb...
Thrilled to share our new paper in MBE! 🎉 Presenting DEST 2.0: 530 pooled Drosophila populations spanning 12 years across 6 continents. We map genomic footprints of adaptation, from pesticide resistance to seasonal changes. #PopulationGenetics #Drosophila #Genomics #Evolution
Thrilled to share our new paper in MBE! 🎉 Presenting DEST 2.0: 530 pooled Drosophila populations spanning 12 years across 6 continents. We map genomic footprints of adaptation, from pesticide resistance to seasonal changes. #PopulationGenetics #Drosophila #Genomics #Evolution
Reposted by Ian Dworkin
Guelph Bug Day is happening THIS SUNDAY! 🐝🪲🐜
📅 Sunday, August 24, 2025
🕙 10 AM – 4 PM
📍 Summerlee Science Complex, Waasamowin Atrium – University of Guelph
This FREE, hands-on event is perfect for curious minds of all ages🐛🐞🕷️
📅 Sunday, August 24, 2025
🕙 10 AM – 4 PM
📍 Summerlee Science Complex, Waasamowin Atrium – University of Guelph
This FREE, hands-on event is perfect for curious minds of all ages🐛🐞🕷️
August 19, 2025 at 6:08 PM
Guelph Bug Day is happening THIS SUNDAY! 🐝🪲🐜
📅 Sunday, August 24, 2025
🕙 10 AM – 4 PM
📍 Summerlee Science Complex, Waasamowin Atrium – University of Guelph
This FREE, hands-on event is perfect for curious minds of all ages🐛🐞🕷️
📅 Sunday, August 24, 2025
🕙 10 AM – 4 PM
📍 Summerlee Science Complex, Waasamowin Atrium – University of Guelph
This FREE, hands-on event is perfect for curious minds of all ages🐛🐞🕷️
Reposted by Ian Dworkin
SLiM 5: Eco-evolutionary simulations across multiple chromosomes and full genomes https://www.biorxiv.org/content/10.1101/2025.08.07.669155v1
August 11, 2025 at 9:32 PM
SLiM 5: Eco-evolutionary simulations across multiple chromosomes and full genomes https://www.biorxiv.org/content/10.1101/2025.08.07.669155v1
Reposted by Ian Dworkin
FlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employees’ salaries was canceled. Scientists warn that losing FlyBase could devastate fly research.
By @claudia-lopez.bsky.social
www.thetransmitter.org/community/ha...
By @claudia-lopez.bsky.social
www.thetransmitter.org/community/ha...
Harvard University lays off fly database team
The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.
www.thetransmitter.org
August 13, 2025 at 7:32 PM
FlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employees’ salaries was canceled. Scientists warn that losing FlyBase could devastate fly research.
By @claudia-lopez.bsky.social
www.thetransmitter.org/community/ha...
By @claudia-lopez.bsky.social
www.thetransmitter.org/community/ha...
Reposted by Ian Dworkin
💬 "There’s already plenty of documentation out there for how to use #ggtree, but there is the odd thing I come up against that I haven’t seen explicitly demonstrated before." - @rowenahill.bsky.social.
A guide to plotting #phylogenetictrees in #R, and automating clade highlights
buff.ly/Vd5b61a
🧬💻
A guide to plotting #phylogenetictrees in #R, and automating clade highlights
buff.ly/Vd5b61a
🧬💻
Plotting phylogenetic trees in R: alternating clade highlights
A guide to highlighting clades in phylogenetic trees in R
buff.ly
August 1, 2025 at 11:01 AM
💬 "There’s already plenty of documentation out there for how to use #ggtree, but there is the odd thing I come up against that I haven’t seen explicitly demonstrated before." - @rowenahill.bsky.social.
A guide to plotting #phylogenetictrees in #R, and automating clade highlights
buff.ly/Vd5b61a
🧬💻
A guide to plotting #phylogenetictrees in #R, and automating clade highlights
buff.ly/Vd5b61a
🧬💻
Reposted by Ian Dworkin
Reposted by Ian Dworkin
Priceless! 😆
For all you #paleobiology parents.
For all you #paleobiology parents.
July 15, 2025 at 9:33 PM
Priceless! 😆
For all you #paleobiology parents.
For all you #paleobiology parents.
Reposted by Ian Dworkin
The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field?
That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience
A 🧵 1/n
That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience
A 🧵 1/n
July 10, 2025 at 8:23 AM
The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field?
That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience
A 🧵 1/n
That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience
A 🧵 1/n
Reposted by Ian Dworkin
Ontogeny of escape response and body shape in Threespine Stickleback (Gasterosteus aculeatus L.) https://www.biorxiv.org/content/10.1101/2025.07.09.663780v1
July 12, 2025 at 6:32 AM
Ontogeny of escape response and body shape in Threespine Stickleback (Gasterosteus aculeatus L.) https://www.biorxiv.org/content/10.1101/2025.07.09.663780v1
Reposted by Ian Dworkin
Mesquite 4.0 released! A major update — many new features, small and large (phylogenomics, visualizations, workflow management, &c). Check out the trailer video: www.mesquiteproject.org.
Come discuss in our new Google Group (groups.google.com/g/mesquite-project). @bembidion.bsky.social 🧪 #evolbio
Come discuss in our new Google Group (groups.google.com/g/mesquite-project). @bembidion.bsky.social 🧪 #evolbio
June 27, 2025 at 11:16 PM
Mesquite 4.0 released! A major update — many new features, small and large (phylogenomics, visualizations, workflow management, &c). Check out the trailer video: www.mesquiteproject.org.
Come discuss in our new Google Group (groups.google.com/g/mesquite-project). @bembidion.bsky.social 🧪 #evolbio
Come discuss in our new Google Group (groups.google.com/g/mesquite-project). @bembidion.bsky.social 🧪 #evolbio
Reposted by Ian Dworkin
European-based researchers can help support future #flybase curation by donating at this site: www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 11, 2025 at 11:10 AM
European-based researchers can help support future #flybase curation by donating at this site: www.philanthropy.cam.ac.uk/give-to-camb...
Reposted by Ian Dworkin
We are excited to announce that tidypopgen – a new package for rapid population genetic workflows in R – is now available at evolecolgroup.github.io/tidypopgen/ 🧬💻 Read more in the preprint describing its features here: www.biorxiv.org/content/10.1... #popgen #Rpackage #genetics 1/2
Tidy Population Genetics
We provide a tidy grammar of population genetics, facilitating the manipulation and analysis of data on biallelic single nucleotide polymorphisms (SNPs). `tidypopgen` scales to very large genetic data...
evolecolgroup.github.io
June 20, 2025 at 12:19 PM
We are excited to announce that tidypopgen – a new package for rapid population genetic workflows in R – is now available at evolecolgroup.github.io/tidypopgen/ 🧬💻 Read more in the preprint describing its features here: www.biorxiv.org/content/10.1... #popgen #Rpackage #genetics 1/2
Reposted by Ian Dworkin
Reposted by Ian Dworkin
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
June 3, 2025 at 9:17 PM
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
Reposted by Ian Dworkin
FlyBase, a crucial resource for drosophila research, has lost its funding because its grant is awarded to Harvard. The team is scrambling to find other sources of funds, including donations from labs. Read more: www.thetransmitter.org/community/fl... @flybase.bsky.social
FlyBase funding squashed amid Harvard grant terminations
The team behind the Drosophila genetics database is now requesting donations from labs to keep the resource afloat.
www.thetransmitter.org
June 4, 2025 at 9:11 PM
FlyBase, a crucial resource for drosophila research, has lost its funding because its grant is awarded to Harvard. The team is scrambling to find other sources of funds, including donations from labs. Read more: www.thetransmitter.org/community/fl... @flybase.bsky.social
Reposted by Ian Dworkin
Super excited to release a huge evolution project on the works for many years:
Evolution experiments synchronized across climates to understand rapid adaptation
Preprint: doi.org/10.1101/2025...
All data available: www.grene-net.org/data
#MOILAB
@ucberkeleyofficial.bsky.social
@hhmi.org
🧵👇
Evolution experiments synchronized across climates to understand rapid adaptation
Preprint: doi.org/10.1101/2025...
All data available: www.grene-net.org/data
#MOILAB
@ucberkeleyofficial.bsky.social
@hhmi.org
🧵👇
May 30, 2025 at 5:56 PM
Super excited to release a huge evolution project on the works for many years:
Evolution experiments synchronized across climates to understand rapid adaptation
Preprint: doi.org/10.1101/2025...
All data available: www.grene-net.org/data
#MOILAB
@ucberkeleyofficial.bsky.social
@hhmi.org
🧵👇
Evolution experiments synchronized across climates to understand rapid adaptation
Preprint: doi.org/10.1101/2025...
All data available: www.grene-net.org/data
#MOILAB
@ucberkeleyofficial.bsky.social
@hhmi.org
🧵👇