Γδ T cells are non-conventional T cells that are not MHC restricted and have T cell receptors (TCRs) that are stimulated by phosphoantigens, stress-induced proteins, lipids, and other antigens. These cells are prognostic across cancer types in The Cancer Genome Atlas (TCGA) but have not been well studied in endometrial cancer, which has a rising incidence and mortality rate. Endometrial cancer patients have variable responses to checkpoint inhibitors which are related to the molecular subtype of their cancer. As such, there is a pressing need to understand the immune microenvironment in endometrial cancer. This study addresses this gap in knowledge by investigating γδ T cell repertoires and transcriptomes in this disease site. γδ T cell repertoires were obtained for 543 endometrial cancer patients within the TCGA and from 5 endometrial cancer patients in the single cell dataset SRP349751 using TRUST4. GLIPH2 was used to identify TCRs predicted to bind the same antigen. Transcriptomes were investigated in the single cell dataset. DNA Polymerase Epsilon Exonuclease (POLE) and Microsatellite Instability High (MSI-H) endometrial cancer subtypes had the most γδ T cell infiltration. Vδ1 and Vδ3 γδ T cell infiltration was prognostic independent of stage and molecular subtype. GLIPH2 analysis revealed TCRδ motifs for TDK, YTD, and GEL were public across all four molecular subtypes and were present in the single cell data set. Vδ1 γδ T cell transcriptomes were associated with cytotoxicity and recent TCR stimulation. These data support further investigation of immunotherapies targeting γδ T cells in endometrial cancer.

Paceline raises funds for innovative cancer research at the Georgia Cancer Center. . Donate directly to the Immunity Strong Paceline team here.

Paceline raises funds for innovative cancer research at the Georgia Cancer Center. . Donate directly to the Immunity Strong Paceline team here.

“I want to work toward more effective ways of treating and screening cancer, specifically, in my case, melanoma," says Elayne Benson.

Two graduate students from the Immunology Center of Georgia will use NIH awards to explore the immunological drivers behind cardiometabolic disease.

Please help me support PaceDay 2025! 100% of every dollar raised goes to innovative cancer research at the Georgia Cancer Center. Donate, register to ride, or invite others to support the fight agains...

“A patient’s immune system is unique. With clearer markers, we can better understand how to tailor therapies to each person’s condition," says Mohammad Oliaeimotlagh, MD.

Please help me support PaceDay 2025! 100% of every dollar raised goes to innovative cancer research at the Georgia Cancer Center. Donate, register to ride, or invite others to support the fight agains...

YouTube video by Medical College of Georgia

New research from the Immunology Center of Georgia is changing how scientists view the autoimmune side of heart disease.

The discovery of plaque tertiary lymphoid organs (PTLOs) within human atherosclerotic plaques provides insights into the role of the immune system in atherosclerosis. The findings highlight the cellul...

Atherosclerosis is a complex immuno-metabolic disease characterized by lipid accumulation and chronic inflammation within arterial walls, leading to cardiova...