IMP
@impvienna.bsky.social
The IMP is a leading life science centre in Europe with 220 researchers from 40 countries. Part of the ViennaBioCenter.
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IMP
@impvienna.bsky.social
· Feb 10
At the IMP we’re dedicated to the fun of finding out. Few places in the world let you dive into curiosity-driven science like we do.
📽️Watch what the IMP is all about: youtu.be/mtl5Vod652Q
@viennabiocenter.bsky.social
📽️Watch what the IMP is all about: youtu.be/mtl5Vod652Q
@viennabiocenter.bsky.social
To regulate gene activity, proteasomes - waste disposal machines of cells - must enter the nucleus. IMP Researchers now show how the adaptor protein AKIRIN2 helps ferry this massive complex through the nuclear pore: https://www.nature.com/articles/s41467-026-69162-0
February 11, 2026 at 10:20 AM
To regulate gene activity, proteasomes - waste disposal machines of cells - must enter the nucleus. IMP Researchers now show how the adaptor protein AKIRIN2 helps ferry this massive complex through the nuclear pore: https://www.nature.com/articles/s41467-026-69162-0
Sven Klumpe, joint Group Leader at the IMP and IMBA has received a grant by the Chan Zuckerberg Initiative’s Biohub to support fibsem-os, an open-source software platform for focused ion beam–scanning electron microscopy.
Read more 👉 https://imba.science/4tiwEP9
Read more 👉 https://imba.science/4tiwEP9
February 5, 2026 at 10:15 AM
Sven Klumpe, joint Group Leader at the IMP and IMBA has received a grant by the Chan Zuckerberg Initiative’s Biohub to support fibsem-os, an open-source software platform for focused ion beam–scanning electron microscopy.
Read more 👉 https://imba.science/4tiwEP9
Read more 👉 https://imba.science/4tiwEP9
🔬 Our Research Milestones essays are back!
This feature highlights Alipasha Vaziri, former Group Leader at the IMP and Max Perutz Labs.
At the IMP, he developed imaging technologies that enabled large-scale recording of neuronal activity at single-cell resolution:
This feature highlights Alipasha Vaziri, former Group Leader at the IMP and Max Perutz Labs.
At the IMP, he developed imaging technologies that enabled large-scale recording of neuronal activity at single-cell resolution:
February 2, 2026 at 1:05 PM
🔬 Our Research Milestones essays are back!
This feature highlights Alipasha Vaziri, former Group Leader at the IMP and Max Perutz Labs.
At the IMP, he developed imaging technologies that enabled large-scale recording of neuronal activity at single-cell resolution:
This feature highlights Alipasha Vaziri, former Group Leader at the IMP and Max Perutz Labs.
At the IMP, he developed imaging technologies that enabled large-scale recording of neuronal activity at single-cell resolution:
Reposted by IMP
Paper alert! 📢 How do cells fight viruses without harming themselves? 🧬 In @natcomms.nature.com, the @versteegga.bsky.social lab uncover a previously unknown safeguard that keeps DNA-mutating antiviral enzymes in check, protecting the genome while preserving antiviral defense ➡️ tinyurl.com/4xbxz9e8
January 30, 2026 at 11:05 AM
Paper alert! 📢 How do cells fight viruses without harming themselves? 🧬 In @natcomms.nature.com, the @versteegga.bsky.social lab uncover a previously unknown safeguard that keeps DNA-mutating antiviral enzymes in check, protecting the genome while preserving antiviral defense ➡️ tinyurl.com/4xbxz9e8
We are hiring! Join our Sterile Processing Unit as a technical assistant and provide scientists at the IMP, IMBA, and GMI with sterile laboratory glass and plastic goods.
January 30, 2026 at 10:05 AM
We are hiring! Join our Sterile Processing Unit as a technical assistant and provide scientists at the IMP, IMBA, and GMI with sterile laboratory glass and plastic goods.
Plasma cells are the immune system’s antibody factories, producing the molecules that protect us after infection or vaccination. They originate from B cell. Yet how B cells make the switch to become plasma cells—and which genes control this transition—isn’t known.
Researchers from the lab of
Researchers from the lab of
January 29, 2026 at 8:20 AM
Plasma cells are the immune system’s antibody factories, producing the molecules that protect us after infection or vaccination. They originate from B cell. Yet how B cells make the switch to become plasma cells—and which genes control this transition—isn’t known.
Researchers from the lab of
Researchers from the lab of
Plasma cells are the immune system’s antibody factories, and they originate from B-cells.
Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:
Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:
January 29, 2026 at 8:20 AM
Plasma cells are the immune system’s antibody factories, and they originate from B-cells.
Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:
Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:
New work from our Haselbach lab with collaborators captures ribosomes 𝘮𝘪𝘥-𝘣𝘶𝘪𝘭𝘥 and reveals a flexible, modular strategy behind their assembly, rather than a strict assembly line.
Published in _Nucleic Acids Research _👉 https://doi.org/10.1093/nar/gkag036
Published in _Nucleic Acids Research _👉 https://doi.org/10.1093/nar/gkag036
January 27, 2026 at 3:33 PM
New work from our Haselbach lab with collaborators captures ribosomes 𝘮𝘪𝘥-𝘣𝘶𝘪𝘭𝘥 and reveals a flexible, modular strategy behind their assembly, rather than a strict assembly line.
Published in _Nucleic Acids Research _👉 https://doi.org/10.1093/nar/gkag036
Published in _Nucleic Acids Research _👉 https://doi.org/10.1093/nar/gkag036
Reposted by IMP
Check out our new paper in @natcomms.nature.com .com where we used #cryoEM together with biochemical and mutational analyses investigated the cotranslational protein folding by Ssb in yeast.
Publication: doi.org/10.1038/s41467-025-67685-6
Check below for the cryoEM centric feed. 👇
Publication: doi.org/10.1038/s41467-025-67685-6
Check below for the cryoEM centric feed. 👇
January 27, 2026 at 2:59 PM
Check out our new paper in @natcomms.nature.com .com where we used #cryoEM together with biochemical and mutational analyses investigated the cotranslational protein folding by Ssb in yeast.
Publication: doi.org/10.1038/s41467-025-67685-6
Check below for the cryoEM centric feed. 👇
Publication: doi.org/10.1038/s41467-025-67685-6
Check below for the cryoEM centric feed. 👇
BLOC-1 and BORC help move and position lysosomes inside cells. New work from the Haselbach and Clausen labs shows they are not uniform complexes, but families of related protein assemblies. Published in PNAS: https://www.pnas.org/doi/10.1073/pnas.2515691123
January 21, 2026 at 9:35 AM
BLOC-1 and BORC help move and position lysosomes inside cells. New work from the Haselbach and Clausen labs shows they are not uniform complexes, but families of related protein assemblies. Published in PNAS: https://www.pnas.org/doi/10.1073/pnas.2515691123
🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made.
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
January 19, 2026 at 9:40 AM
🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made.
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
Reposted by IMP
SY-Stem 2026 brings two outstanding keynote speakers to the Vienna BioCenter. SY-Stem is a symposium focusing on the next generation of stem cell researchers, organized by the @impvienna.bsky.social & @imbavienna.bsky.social
March 11-13, 2026
Program and registration: www.sy-stem.org
March 11-13, 2026
Program and registration: www.sy-stem.org
January 15, 2026 at 9:08 AM
SY-Stem 2026 brings two outstanding keynote speakers to the Vienna BioCenter. SY-Stem is a symposium focusing on the next generation of stem cell researchers, organized by the @impvienna.bsky.social & @imbavienna.bsky.social
March 11-13, 2026
Program and registration: www.sy-stem.org
March 11-13, 2026
Program and registration: www.sy-stem.org
Reposted by IMP
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
December 24, 2025 at 3:51 PM
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
Reposted by IMP
Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
Activator-promoter compatibility in mammals: a CpG-Island-specific co-activator directly bridges transcription factors to TFIID
Transcription from CpG island (CGI) promoters controls the expression of two-thirds of mammalian genes, yet despite their prevalence, it remains unknown whether CGI-specific co-activators with intrins...
www.biorxiv.org
December 30, 2025 at 8:02 AM
Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
Congratulations to our Anna Obenauf, Senior Group Leader at the IMP, for receiving the EJI Ita Askonas Prize 2025 for her pioneering work uncovering how cancer evolution, therapy resistance, and immune evasion are intertwined.
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December 19, 2025 at 1:40 PM
Congratulations to our Anna Obenauf, Senior Group Leader at the IMP, for receiving the EJI Ita Askonas Prize 2025 for her pioneering work uncovering how cancer evolution, therapy resistance, and immune evasion are intertwined.
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🎉 Congrats to IMP group leaders Joris van der Veeken & Moritz Gaidt on receiving FWF Stand-Alone grants! Their projects will explore how gene regulation shapes immune cell identity & function. A 3rd grant supports Manuel Matzinger:
December 17, 2025 at 3:24 PM
🎉 Congrats to IMP group leaders Joris van der Veeken & Moritz Gaidt on receiving FWF Stand-Alone grants! Their projects will explore how gene regulation shapes immune cell identity & function. A 3rd grant supports Manuel Matzinger:
In a new paper in the EMBO Journal, researchers in the Pavri lab and collaborators, show how “genetic grammar” affect the rate at which somatic hypermutation, the process by which T cells purposely mutate their DNA to generate evolved antibodies : https://bit.ly/4aHetMg
December 12, 2025 at 3:45 PM
In a new paper in the EMBO Journal, researchers in the Pavri lab and collaborators, show how “genetic grammar” affect the rate at which somatic hypermutation, the process by which T cells purposely mutate their DNA to generate evolved antibodies : https://bit.ly/4aHetMg
SY-Stem 2026 is here! The symposium focusing on the next generation of stem cell researchers returns to the Vienna BioCenter from 11–13 March 2026. Register online: sy-stem.org
December 10, 2025 at 4:10 PM
SY-Stem 2026 is here! The symposium focusing on the next generation of stem cell researchers returns to the Vienna BioCenter from 11–13 March 2026. Register online: sy-stem.org
Clemens Plaschka, Senior Group Leader at the IMP, has been awarded an ERC Consolidator grant!
His project on the fate control of messenger RNA (mRNA) will be supported with funding over the next five years.
➡️ Read more:
His project on the fate control of messenger RNA (mRNA) will be supported with funding over the next five years.
➡️ Read more:
December 9, 2025 at 2:05 PM
Clemens Plaschka, Senior Group Leader at the IMP, has been awarded an ERC Consolidator grant!
His project on the fate control of messenger RNA (mRNA) will be supported with funding over the next five years.
➡️ Read more:
His project on the fate control of messenger RNA (mRNA) will be supported with funding over the next five years.
➡️ Read more:
Nature featured work from our Pauli lab, where AlphaFold-Multimer helped reveal how Tmem81 and two sperm proteins create the pocket for the egg protein Bouncer to bind.
Andrea Pauli: “AlphaFold speeds up discovery, we use it for every project.”
🔗 www.nature.com/articles/d41...
Andrea Pauli: “AlphaFold speeds up discovery, we use it for every project.”
🔗 www.nature.com/articles/d41...
AlphaFold is five years old — these charts show how it revolutionized science
Since it was unveiled in 2020, Google DeepMind's game-changing AI tool has helped researchers all over the world to predict the 3D structures of hundreds of millions of proteins.
www.nature.com
November 27, 2025 at 1:04 PM
Nature featured work from our Pauli lab, where AlphaFold-Multimer helped reveal how Tmem81 and two sperm proteins create the pocket for the egg protein Bouncer to bind.
Andrea Pauli: “AlphaFold speeds up discovery, we use it for every project.”
🔗 www.nature.com/articles/d41...
Andrea Pauli: “AlphaFold speeds up discovery, we use it for every project.”
🔗 www.nature.com/articles/d41...
Congratulations to Paul Kirchgatterer, PhD student in Moritz Gaidt’s lab, who was awarded the Out of the Box Award for his project aiming to identify vulnerable viral genes that can be targeted to develop antiviral treatments. More: bit.ly/4pCLYDH
November 27, 2025 at 9:59 AM
Congratulations to Paul Kirchgatterer, PhD student in Moritz Gaidt’s lab, who was awarded the Out of the Box Award for his project aiming to identify vulnerable viral genes that can be targeted to develop antiviral treatments. More: bit.ly/4pCLYDH
“…[at the IMP] collaborations can develop naturally across many projects…”
We sat down with Jacob Schreiber after he wrapped up his one-year stay at the IMP, and he told us all about it: www.imp.ac.at/news/article...
@jmschreiber91.bsky.social, @viennabiocenter.bsky.social
We sat down with Jacob Schreiber after he wrapped up his one-year stay at the IMP, and he told us all about it: www.imp.ac.at/news/article...
@jmschreiber91.bsky.social, @viennabiocenter.bsky.social
November 25, 2025 at 1:42 PM
“…[at the IMP] collaborations can develop naturally across many projects…”
We sat down with Jacob Schreiber after he wrapped up his one-year stay at the IMP, and he told us all about it: www.imp.ac.at/news/article...
@jmschreiber91.bsky.social, @viennabiocenter.bsky.social
We sat down with Jacob Schreiber after he wrapped up his one-year stay at the IMP, and he told us all about it: www.imp.ac.at/news/article...
@jmschreiber91.bsky.social, @viennabiocenter.bsky.social
Reposted by IMP
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 21, 2025 at 5:37 PM
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
Scientists around former IMP group leader David Keays (@lmumuenchen.bsky.social show that #pigeons detect magnetic fields through their inner ear. Their discovery was now published in the journal @science.org: www.science.org/doi/10.1126/...
More: www.imp.ac.at/news/article...
More: www.imp.ac.at/news/article...
A global screen for magnetically induced neuronal activity in the pigeon brain
How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...
www.science.org
November 20, 2025 at 7:17 PM
Scientists around former IMP group leader David Keays (@lmumuenchen.bsky.social show that #pigeons detect magnetic fields through their inner ear. Their discovery was now published in the journal @science.org: www.science.org/doi/10.1126/...
More: www.imp.ac.at/news/article...
More: www.imp.ac.at/news/article...
Congratulations to Anais Elewaut, former PhD student in Anna Obenauf’s lab, who was awarded the Denise P. Barlow Award for her exceptional doctoral research on how tumours evade the immune system. More: www.imp.ac.at/news/article...
November 20, 2025 at 1:53 PM
Congratulations to Anais Elewaut, former PhD student in Anna Obenauf’s lab, who was awarded the Denise P. Barlow Award for her exceptional doctoral research on how tumours evade the immune system. More: www.imp.ac.at/news/article...