Intensive Care Medicine Journal
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Intensive Care Medicine serves as the premier publication platform facilitating the communication and exchange of cutting-edge research and ideas within the field of intensive care medicine on a comprehensive scale. This platform is designed for profession
A German population-wide cohort shows that older ICU survivors have higher five-year mortality and greater risk of functional decline than their peers, with the greatest impact seen in previously fit adults aged 60–79 years. zurl.co/wUEY7
December 2, 2025 at 9:00 AM
A German population-wide cohort shows that older ICU survivors have higher five-year mortality and greater risk of functional decline than their peers, with the greatest impact seen in previously fit adults aged 60–79 years. zurl.co/wUEY7
After acute brain injury, transfusion decisions should consider haemoglobin’s proton-buffering role and the impact of 2,3-DPG-depleted stored blood, not just global oxygen delivery targets. zurl.co/tfoRo
December 1, 2025 at 5:00 PM
After acute brain injury, transfusion decisions should consider haemoglobin’s proton-buffering role and the impact of 2,3-DPG-depleted stored blood, not just global oxygen delivery targets. zurl.co/tfoRo
#VisualAbstract Pharmaceutical poisonings make up to 10% of ICU admissions. The review outlines ABCDE-based stabilisation and when to escalate from supportive care to decontamination, extracorporeal removal, antidotes, lipid emulsion or VA-ECMO. zurl.co/hOjyW
December 1, 2025 at 9:00 AM
#VisualAbstract Pharmaceutical poisonings make up to 10% of ICU admissions. The review outlines ABCDE-based stabilisation and when to escalate from supportive care to decontamination, extracorporeal removal, antidotes, lipid emulsion or VA-ECMO. zurl.co/hOjyW
Intracranial pressure dose, integrating magnitude and duration of ICP elevation, offers a more physiologically meaningful and prognostically robust metric than fixed thresholds in traumatic brain injury and subarachnoid haemorrhage. zurl.co/C6Ndt
November 30, 2025 at 5:00 PM
Intracranial pressure dose, integrating magnitude and duration of ICP elevation, offers a more physiologically meaningful and prognostically robust metric than fixed thresholds in traumatic brain injury and subarachnoid haemorrhage. zurl.co/C6Ndt
#ICM-Quizz #MedEd Serum sickness is an immune complex–mediated type III reaction, often following snake antivenoms, vaccines, or monoclonal antibodies. It typically appears 7–14 days post exposure with rash, fever, malaise, and hypocomplementemia. zurl.co/r7O3H
November 30, 2025 at 9:00 AM
#ICM-Quizz #MedEd Serum sickness is an immune complex–mediated type III reaction, often following snake antivenoms, vaccines, or monoclonal antibodies. It typically appears 7–14 days post exposure with rash, fever, malaise, and hypocomplementemia. zurl.co/r7O3H
TIMING trial authors acknowledge limited power, reaffirm support for delaying invasive intervention in necrotizing pancreatitis, and report that early catheter drainage was safe without increasing infected pancreatic necrosis. zurl.co/3eoVp
November 29, 2025 at 9:00 AM
TIMING trial authors acknowledge limited power, reaffirm support for delaying invasive intervention in necrotizing pancreatitis, and report that early catheter drainage was safe without increasing infected pancreatic necrosis. zurl.co/3eoVp
Randomised cross-over trial in 88 CVVH patients with regional citrate anticoagulation shows low bicarbonate replacement fluid causes fewer pH and bicarbonate excursions than high bicarbonate fluid, with similar pH normalisation in acidotic patients. zurl.co/5UxYl
November 28, 2025 at 5:00 PM
Randomised cross-over trial in 88 CVVH patients with regional citrate anticoagulation shows low bicarbonate replacement fluid causes fewer pH and bicarbonate excursions than high bicarbonate fluid, with similar pH normalisation in acidotic patients. zurl.co/5UxYl
ESICM issues 2025 guidelines on circulatory shock, defining shock as acute circulatory failure with tissue hypoperfusion and offering 50 recommendations on clinical assessment, hemodynamic monitoring, fluid responsiveness and use of echocardiography. zurl.co/invjr
November 28, 2025 at 9:00 AM
ESICM issues 2025 guidelines on circulatory shock, defining shock as acute circulatory failure with tissue hypoperfusion and offering 50 recommendations on clinical assessment, hemodynamic monitoring, fluid responsiveness and use of echocardiography. zurl.co/invjr
#VisualAbstract Across 213 studies in adult ICUs, delirium affected about one-third of patients and pain about two-fifths; both have fallen since pain, agitation and delirium guidelines, yet remain common. zurl.co/Um39j
November 27, 2025 at 5:00 PM
#VisualAbstract Across 213 studies in adult ICUs, delirium affected about one-third of patients and pain about two-fifths; both have fallen since pain, agitation and delirium guidelines, yet remain common. zurl.co/Um39j
Authors critique the 4D trial of dexmedetomidine for hyperactive delirium, highlighting early stopping, a heterogeneous composite endpoint, haloperidol co-administration, and limited impact on patient-centered outcomes in non-intubated ICU patients. zurl.co/SbOfn
November 27, 2025 at 9:00 AM
Authors critique the 4D trial of dexmedetomidine for hyperactive delirium, highlighting early stopping, a heterogeneous composite endpoint, haloperidol co-administration, and limited impact on patient-centered outcomes in non-intubated ICU patients. zurl.co/SbOfn
Delirium in ICU patients, particularly hyperactive delirium, remains challenging. While dexmedetomidine has shown potential for agitation control, the trial results indicate limited evidence for delirium resolution or prevention of intubation. zurl.co/0fvtR
November 26, 2025 at 5:00 PM
Delirium in ICU patients, particularly hyperactive delirium, remains challenging. While dexmedetomidine has shown potential for agitation control, the trial results indicate limited evidence for delirium resolution or prevention of intubation. zurl.co/0fvtR
Healthcare generates ~5% of global emissions; ICUs have nearly triple other wards’ footprint. The authors call to embed sustainability into undergraduate critical care teaching to equip future doctors for climate-conscious practice. zurl.co/eJ7Qx
November 26, 2025 at 9:00 AM
Healthcare generates ~5% of global emissions; ICUs have nearly triple other wards’ footprint. The authors call to embed sustainability into undergraduate critical care teaching to equip future doctors for climate-conscious practice. zurl.co/eJ7Qx
#VisualAbstract An ICU follow-up model for family caregivers reduced PTSD symptoms at 6 months in a randomised trial of 196 participants, with strongest effects when the patient survived and benefits persisting at 12 months. zurl.co/WtFbf
November 25, 2025 at 5:00 PM
#VisualAbstract An ICU follow-up model for family caregivers reduced PTSD symptoms at 6 months in a randomised trial of 196 participants, with strongest effects when the patient survived and benefits persisting at 12 months. zurl.co/WtFbf
Burn shock resuscitation is shifting from fixed formulas to goal-directed titration focused on organ perfusion and avoiding fluid overload. Balanced crystalloids, selective albumin, early debridement and cautious vasopressors are emphasised. zurl.co/aZUUA
November 25, 2025 at 9:00 AM
Burn shock resuscitation is shifting from fixed formulas to goal-directed titration focused on organ perfusion and avoiding fluid overload. Balanced crystalloids, selective albumin, early debridement and cautious vasopressors are emphasised. zurl.co/aZUUA
Individualised PEEP in acute brain injury should reflect subtype differences across TBI, ICH, SAH and ischaemic stroke. SAH vulnerability is highlighted. Protocols should be stratified by injury type, phase and recruitability. zurl.co/rO0wt
November 24, 2025 at 5:00 PM
Individualised PEEP in acute brain injury should reflect subtype differences across TBI, ICH, SAH and ischaemic stroke. SAH vulnerability is highlighted. Protocols should be stratified by injury type, phase and recruitability. zurl.co/rO0wt
Norepinephrine is increasingly used in perioperative care for haemodynamic management, with benefits in stabilising blood pressure during surgery and reducing adverse outcomes linked to hypotension. zurl.co/kFyFN
November 24, 2025 at 9:00 AM
Norepinephrine is increasingly used in perioperative care for haemodynamic management, with benefits in stabilising blood pressure during surgery and reducing adverse outcomes linked to hypotension. zurl.co/kFyFN
#1minutevideo Higher hospital-level use of continuous kidney replacement therapy in critically ill patients with AKI was linked to lower risk-adjusted mortality, suggesting that greater CKRT utilisation may reflect more effective care. zurl.co/zTsVe
November 23, 2025 at 5:01 PM
#1minutevideo Higher hospital-level use of continuous kidney replacement therapy in critically ill patients with AKI was linked to lower risk-adjusted mortality, suggesting that greater CKRT utilisation may reflect more effective care. zurl.co/zTsVe
A 4D trial analysis finds dexmedetomidine shows a global benefit in non-intubated ICU hyperactive delirium, with less rescue medication and no safety signals, while questioning joint Z-score endpoints and early stopping for efficacy. zurl.co/jncbI
November 23, 2025 at 9:00 AM
A 4D trial analysis finds dexmedetomidine shows a global benefit in non-intubated ICU hyperactive delirium, with less rescue medication and no safety signals, while questioning joint Z-score endpoints and early stopping for efficacy. zurl.co/jncbI
Invasive meningococcal disease is rare yet deadly, with post-pandemic rebounds and shifting serogroups. Early recognition and antibiotics improve survival, while hemodynamic failure drives mortality and sequelae. zurl.co/vrjap
November 22, 2025 at 5:00 PM
Invasive meningococcal disease is rare yet deadly, with post-pandemic rebounds and shifting serogroups. Early recognition and antibiotics improve survival, while hemodynamic failure drives mortality and sequelae. zurl.co/vrjap
Bedside guidance on vasopressin in septic shock: start early with norepinephrine, use fixed low doses with 0.005 IU/min titration, prefer central access, monitor for digital ischaemia; major trials found no overall survival benefit. zurl.co/1bsJo
November 22, 2025 at 9:00 AM
Bedside guidance on vasopressin in septic shock: start early with norepinephrine, use fixed low doses with 0.005 IU/min titration, prefer central access, monitor for digital ischaemia; major trials found no overall survival benefit. zurl.co/1bsJo
#VisualAbstract Invasive candidiasis in ICU care demands faster rule-in/rule-out diagnostics, risk-stratified therapy and rigorous stewardship. Rising non-albicans species and resistance make team-based management and source control key to improving outcomes. zurl.co/c7fhh
November 21, 2025 at 5:00 PM
#VisualAbstract Invasive candidiasis in ICU care demands faster rule-in/rule-out diagnostics, risk-stratified therapy and rigorous stewardship. Rising non-albicans species and resistance make team-based management and source control key to improving outcomes. zurl.co/c7fhh
Authors state that ‘early’ mobilisation in ICU after surgery should use 72 hours as an upper boundary within ERAS, alongside prehabilitation. Evidence shows no overall advantage for 24 versus 72 hours, and stronger randomised data are still needed. zurl.co/RklsU
November 21, 2025 at 9:00 AM
Authors state that ‘early’ mobilisation in ICU after surgery should use 72 hours as an upper boundary within ERAS, alongside prehabilitation. Evidence shows no overall advantage for 24 versus 72 hours, and stronger randomised data are still needed. zurl.co/RklsU
In 77 critically ill adults on ceftriaxone, higher unbound 24-h AUC was associated with faster CRP decline over 10 days than lower exposure, after adjustment, suggesting value for exposure-guided dosing while acknowledging observational limits. zurl.co/NGrJv
November 20, 2025 at 5:00 PM
In 77 critically ill adults on ceftriaxone, higher unbound 24-h AUC was associated with faster CRP decline over 10 days than lower exposure, after adjustment, suggesting value for exposure-guided dosing while acknowledging observational limits. zurl.co/NGrJv
#ICM-Quizz #MedEd Pulmonary artery pulse pressure and an EtCO₂ waveform of 17 mmHg indicate that atrial activity sustains transpulmonary flow and pulmonary venous return. In VA-ECMO without native ejection, EtCO₂ tends to fall below 10 mmHg. zurl.co/5XREe
November 20, 2025 at 9:00 AM
#ICM-Quizz #MedEd Pulmonary artery pulse pressure and an EtCO₂ waveform of 17 mmHg indicate that atrial activity sustains transpulmonary flow and pulmonary venous return. In VA-ECMO without native ejection, EtCO₂ tends to fall below 10 mmHg. zurl.co/5XREe