The Interactive Fly
@interactivefly.bsky.social
The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior
Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
Parkin mediates the mitochondrial dysfunction through mRpL18
Loss of function of parkin leads to mitochondrial dysfunction, which is closely related
to Parkinson's disease. However, the in vivo mechanism is far from clear. One dogma
is that impaired Parkin caus...
www.jbc.org
January 8, 2026 at 9:14 PM
Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
Parkin mediates the mitochondrial dysfunction through mRpL18
Loss of function of parkin leads to mitochondrial dysfunction, which is closely related
to Parkinson's disease. However, the in vivo mechanism is far from clear. One dogma
is that impaired Parkin caus...
www.jbc.org
January 8, 2026 at 9:12 PM
Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
Scudese, E., Marshall, A. G., Vue, Z., Exil, V., ..., Sharma, V., Mobley, B. C., Katti, P., Hinton, A. (2025). 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes. Aging Cell:e70054 onlinelibrary.wiley.com/doi/10.1111/...
January 8, 2026 at 9:11 PM
Scudese, E., Marshall, A. G., Vue, Z., Exil, V., ..., Sharma, V., Mobley, B. C., Katti, P., Hinton, A. (2025). 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes. Aging Cell:e70054 onlinelibrary.wiley.com/doi/10.1111/...
Tan, S. L., Neumann, D., Trim, P. J., ...., O'Keefe, L. V., Hemsley, K. M., Lau, A. A. (2025). Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome. Mol Genet Metab, 145(2):109112 www.sciencedirect.com/science/arti...
Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome
Mucopolysaccharidosis (MPS) types III A and C are inherited neurodegenerative disorders resulting from the lack of a specific enzyme involved in hepar…
www.sciencedirect.com
January 8, 2026 at 9:09 PM
Tan, S. L., Neumann, D., Trim, P. J., ...., O'Keefe, L. V., Hemsley, K. M., Lau, A. A. (2025). Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome. Mol Genet Metab, 145(2):109112 www.sciencedirect.com/science/arti...
Singh, K., Gupta, K., Shukla, S., Kumari, A. P., Kumar, A. (2025). Repurposing Oseltamivir Against CAG Repeat Mediated Toxicity in Huntington's Disease and Spinocerebellar Ataxia Using Cellular and Drosophila Model. ACS Omega, 10(15):14980-14993 pmc.ncbi.nlm.nih.gov/articles/PMC...
January 8, 2026 at 9:08 PM
Singh, K., Gupta, K., Shukla, S., Kumari, A. P., Kumar, A. (2025). Repurposing Oseltamivir Against CAG Repeat Mediated Toxicity in Huntington's Disease and Spinocerebellar Ataxia Using Cellular and Drosophila Model. ACS Omega, 10(15):14980-14993 pmc.ncbi.nlm.nih.gov/articles/PMC...
Song, H., Kim, S., Han, J. E., Kang, K. H., Koh, H. (2025). PDH Inhibition in Drosophila Ameliorates Sensory Dysfunction Induced by Vincristine Treatment in the Chemotherapy-Induced Peripheral Neuropathy Models. Biomedicines, 13(4) www.mdpi.com/2227-9059/13...
January 8, 2026 at 9:07 PM
Song, H., Kim, S., Han, J. E., Kang, K. H., Koh, H. (2025). PDH Inhibition in Drosophila Ameliorates Sensory Dysfunction Induced by Vincristine Treatment in the Chemotherapy-Induced Peripheral Neuropathy Models. Biomedicines, 13(4) www.mdpi.com/2227-9059/13...
Serebryany-Piavsky, V., Egulsky, L., Manoim-Wolkovitz, J. E., Anis, S., Hassin-Baer, S., Parnas, M., Horowitz, M. (2025). The modifying effect of mutant LRRK2 on mutant GBA1-associated Parkinson disease. Hum Mol Genet, 34(14):1184-1203 academic.oup.com/hmg/article/...
The modifying effect of mutant LRRK2 on mutant GBA1-associated Parkinson disease
Abstract. Parkinson disease (PD) is the second most common neurodegenerative disease. While most cases are sporadic, in ~ 5%–10% of PD patients the disease
academic.oup.com
January 8, 2026 at 9:05 PM
Serebryany-Piavsky, V., Egulsky, L., Manoim-Wolkovitz, J. E., Anis, S., Hassin-Baer, S., Parnas, M., Horowitz, M. (2025). The modifying effect of mutant LRRK2 on mutant GBA1-associated Parkinson disease. Hum Mol Genet, 34(14):1184-1203 academic.oup.com/hmg/article/...
Lee, U., Li, C., Langer, C. B., Svetec, N., Zhao, L. (2025). Comparative single-cell analysis of transcriptional bursting reveals the role of genome organization in de novo transcript origination. Proc Natl Acad Sci U S A, 122(18):e2425618122 www.pnas.org/doi/10.1073/...
January 7, 2026 at 7:17 PM
Lee, U., Li, C., Langer, C. B., Svetec, N., Zhao, L. (2025). Comparative single-cell analysis of transcriptional bursting reveals the role of genome organization in de novo transcript origination. Proc Natl Acad Sci U S A, 122(18):e2425618122 www.pnas.org/doi/10.1073/...
Wang, L., Bu, T., Gao, S., ...., Cheng, C., Sun, F. (2025). PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins. Am J Physiol Cell Phys., 328(6):C2032-c2056 journals.physiology.org/doi/full/10....
PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins | American Journal of Physiology-Cell Physiology ...
Prickle 1, an ortholog found in Drosophila, was localized at the Sertoli cell-spermatid interface consistent with its role of supporting the Vangl2 planar cell polarity (PCP), which is an integral mem...
journals.physiology.org
January 7, 2026 at 7:14 PM
Wang, L., Bu, T., Gao, S., ...., Cheng, C., Sun, F. (2025). PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins. Am J Physiol Cell Phys., 328(6):C2032-c2056 journals.physiology.org/doi/full/10....
Ku, H. Y., Bilder, D. (2025). Basement membrane patterning by spatial deployment of a secretion-regulating protease. Proc Natl Acad Sci U S A, 122(20):e2412161122 www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 7, 2026 at 7:10 PM
Ku, H. Y., Bilder, D. (2025). Basement membrane patterning by spatial deployment of a secretion-regulating protease. Proc Natl Acad Sci U S A, 122(20):e2412161122 www.pnas.org/doi/10.1073/...
Simmons, C., Williams, I. H., Bradshaw, T. W., Armstrong, A. R. (2025). Adipocyte-Derived CCHamide-1, Eiger, Growth-Blocking Peptide 3, and Unpaired 2 Regulate Drosophila melanogaster Oogenesis. Biomolecules, 15(4) www.mdpi.com/2218-273X/15...
January 7, 2026 at 7:04 PM
Simmons, C., Williams, I. H., Bradshaw, T. W., Armstrong, A. R. (2025). Adipocyte-Derived CCHamide-1, Eiger, Growth-Blocking Peptide 3, and Unpaired 2 Regulate Drosophila melanogaster Oogenesis. Biomolecules, 15(4) www.mdpi.com/2218-273X/15...
Peng, J., Sun, A., Zheng, J., Zhang, N., Zhang, X., Gao, G. (2025). Testis-specific serine/threonine kinase dTSSK2 regulates sperm motility and male fertility in Drosophila. Commun Biol, 8(1):710 www.nature.com/articles/s42...
Testis-specific serine/threonine kinase dTSSK2 regulates sperm motility and male fertility in Drosophila - Communications Biology
The Drosophila Testis-Specific Serine/Threonine Kinase (dTSSK2), an ortholog of human TSSK4, coordinates sperm flagella assembly and motility. Disruption of dTSSK2 impairs sperm motility, leading to m...
www.nature.com
January 7, 2026 at 7:02 PM
Peng, J., Sun, A., Zheng, J., Zhang, N., Zhang, X., Gao, G. (2025). Testis-specific serine/threonine kinase dTSSK2 regulates sperm motility and male fertility in Drosophila. Commun Biol, 8(1):710 www.nature.com/articles/s42...
Otsune, S., Matsuka, M., Shirakashi, C., Zhang, X., Nakagoshi, H. (2025). Polished Rice Regulates Maturation but Not Survival of Secondary Cells in Drosophila Male Accessory Gland. Genes Cells, 30(3):e70025 onlinelibrary.wiley.com/doi/10.1111/...
January 7, 2026 at 7:01 PM
Otsune, S., Matsuka, M., Shirakashi, C., Zhang, X., Nakagoshi, H. (2025). Polished Rice Regulates Maturation but Not Survival of Secondary Cells in Drosophila Male Accessory Gland. Genes Cells, 30(3):e70025 onlinelibrary.wiley.com/doi/10.1111/...
Harsh, S., Liu, H. Y., Bhaskar, P. K., Rushlow, C., Bach, E. A. (2025). Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program. PLoS Biol, 23(12):e3003535 journals.plos.org/plosbiology/...
Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program
Somatic gonadal sex fate must be actively upheld throughout adulthood to support proper gametogenesis, but how do adult tissues maintain their sexual identity? This study identifies a post-transcripti...
journals.plos.org
January 5, 2026 at 10:19 PM
Harsh, S., Liu, H. Y., Bhaskar, P. K., Rushlow, C., Bach, E. A. (2025). Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program. PLoS Biol, 23(12):e3003535 journals.plos.org/plosbiology/...
Song, Y., Martin, P., Sun, T., Fernandez-Herrero, J., Sanchez-Herrero, E., Pastor-Pareja, J. C. (2025). Mechanical coupling between dorsal and ventral surfaces shapes the Drosophila haltere. Curr Biol, 35(13):3090-3105 www.cell.com/current-biol...
Mechanical coupling between dorsal and ventral surfaces shapes the Drosophila haltere
Song et al. discover that the two surfaces of the Drosophila haltere display dorso-ventral
adhesion, similar to the wing, and that this is essential to sculpt its 3D globular
shape against tissue-wide...
www.cell.com
January 5, 2026 at 10:17 PM
Song, Y., Martin, P., Sun, T., Fernandez-Herrero, J., Sanchez-Herrero, E., Pastor-Pareja, J. C. (2025). Mechanical coupling between dorsal and ventral surfaces shapes the Drosophila haltere. Curr Biol, 35(13):3090-3105 www.cell.com/current-biol...
Bose, A., Schuster, K., Kodali, C., Sonam, S., Smith-Bolton, R. K. (2025). The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila. Sci Adv, 11(23):eads5743 www.science.org/doi/10.1126/...
The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila
The pioneer factor Zelda activates a specific set of developmental and structural genes to end tissue regeneration.
www.science.org
January 5, 2026 at 10:15 PM
Bose, A., Schuster, K., Kodali, C., Sonam, S., Smith-Bolton, R. K. (2025). The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila. Sci Adv, 11(23):eads5743 www.science.org/doi/10.1126/...
Ready, D. F., Chang, H. C. (2025). Drosophila photoreceptor tethering by a laminin-Eys scaffold. iScience, 28(6):112732 www.cell.com/iscience/ful...
January 5, 2026 at 10:11 PM
Ready, D. F., Chang, H. C. (2025). Drosophila photoreceptor tethering by a laminin-Eys scaffold. iScience, 28(6):112732 www.cell.com/iscience/ful...
Hsiao, C. T., Fu, S. J., Cheng, K. M., Lo, H., Tang, C. Y., Chan, C. C., Jeng, C. J. (2025). Restoration of Shal/K(V)4 proteostasis and motor function in a Drosophila model of spinocerebellar ataxia type 19/22. Cell Mol Life Sci, 82(1):181 link.springer.com/article/10.1...
Restoration of Shal/KV4 proteostasis and motor function in a Drosophila model of spinocerebellar ataxia type 19/22 - Cellular and Molecular Life Sciences
Loss-of-function mutations in the human KCND3 gene encoding KV4.3 K+ channels are linked to the autosomal dominant neurodegenerative disease spinocerebellar ataxia type 19/22 (SCA19/22). Previous biop...
link.springer.com
December 31, 2025 at 8:43 PM
Hsiao, C. T., Fu, S. J., Cheng, K. M., Lo, H., Tang, C. Y., Chan, C. C., Jeng, C. J. (2025). Restoration of Shal/K(V)4 proteostasis and motor function in a Drosophila model of spinocerebellar ataxia type 19/22. Cell Mol Life Sci, 82(1):181 link.springer.com/article/10.1...
Kang, P., Liu, P., Hu, Y., Kim, J., Kumar, A., ..., Shimell, M., Powell-Coffman, J. A., O'Connor, M. B., Perrimon, N., Bai, H. (2025).. NF-kappaB-mediated developmental delay extends lifespan in Drosophila. Proc Natl Acad Sci U S A, 122(19):e2420811122 www.pnas.org/doi/10.1073/...
December 31, 2025 at 8:41 PM
Kang, P., Liu, P., Hu, Y., Kim, J., Kumar, A., ..., Shimell, M., Powell-Coffman, J. A., O'Connor, M. B., Perrimon, N., Bai, H. (2025).. NF-kappaB-mediated developmental delay extends lifespan in Drosophila. Proc Natl Acad Sci U S A, 122(19):e2420811122 www.pnas.org/doi/10.1073/...
Hafeez, E., Du, D., Ni, H., Zhu, K., Hu, F., Zhou, J., Chen, D. (2025). Regulation and mechanism of Bletilla striata polysaccharide on delaying aging in Drosophila melanogaster. Int J Biol Macromol, 310(Pt 3):143382 www.sciencedirect.com/science/arti...
December 31, 2025 at 8:37 PM
Hafeez, E., Du, D., Ni, H., Zhu, K., Hu, F., Zhou, J., Chen, D. (2025). Regulation and mechanism of Bletilla striata polysaccharide on delaying aging in Drosophila melanogaster. Int J Biol Macromol, 310(Pt 3):143382 www.sciencedirect.com/science/arti...
Malik, T., Sidisky, J. M., Jones, S., Winters, A., Hocking, B., Rotay, J., Huhulea, E. N., Moran, S., Connors, B., Babcock, D. T. (2025). Synaptic defects in adult drosophila motor neurons in a model of ALS. Hum Mol Genet, 34(14):1204-1215 academic.oup.com/hmg/article-...
Synaptic defects in adult drosophila motor neurons in a model of amyotrophic lateral sclerosis
Abstract. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects motor neurons in the brain and spinal cord. Like other
academic.oup.com
December 31, 2025 at 8:36 PM
Malik, T., Sidisky, J. M., Jones, S., Winters, A., Hocking, B., Rotay, J., Huhulea, E. N., Moran, S., Connors, B., Babcock, D. T. (2025). Synaptic defects in adult drosophila motor neurons in a model of ALS. Hum Mol Genet, 34(14):1204-1215 academic.oup.com/hmg/article-...
Sasaki, S., Satoh, R., Satoh, T., Satoh, A. K. (2025). Lytic photoreceptor cell death caused by Rab escort protein deficiency in Drosophila. FEBS Lett, febs.onlinelibrary.wiley.com/doi/10.1002/...
December 31, 2025 at 8:33 PM
Sasaki, S., Satoh, R., Satoh, T., Satoh, A. K. (2025). Lytic photoreceptor cell death caused by Rab escort protein deficiency in Drosophila. FEBS Lett, febs.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by The Interactive Fly
Promoter competition and Polycomb Response Elements govern transvection efficiency between co-regulated engrailed and invected genes in Drosophila
#Drosophila
#Drosophila
Promoter competition and Polycomb Response Elements govern transvection efficiency between co-regulated engrailed and invected genes in Drosophila
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
December 31, 2025 at 12:23 AM
Promoter competition and Polycomb Response Elements govern transvection efficiency between co-regulated engrailed and invected genes in Drosophila
#Drosophila
#Drosophila
Sarnataro, R., Velasco, C. D., Monaco, N., Kempf, A., Miesenbock, G. (2025). Mitochondrial origins of the pressure to sleep. Nature, 645(8081):722-728 www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
www.nature.com
December 29, 2025 at 6:17 PM
Sarnataro, R., Velasco, C. D., Monaco, N., Kempf, A., Miesenbock, G. (2025). Mitochondrial origins of the pressure to sleep. Nature, 645(8081):722-728 www.nature.com/articles/s41...
Sturner, T., Brooks, P., Serratosa Capdevila, L., Morris, B., ...., Tuthill, J. C., Lee, W. A., Card, G. M., Costa, M., Jefferis, G., Eichler, K. (2025). Comparative connectomics of Drosophila descending and ascending neurons. Nature, 643(8070):158-172 www.nature.com/articles/s41...
Comparative connectomics of Drosophila descending and ascending neurons - Nature
Three electron microscopy datasets are combined to provide a complete connectomic description of the neural circuitry that makes up the neck connective in Drosophila, including the descendin...
www.nature.com
December 29, 2025 at 6:16 PM
Sturner, T., Brooks, P., Serratosa Capdevila, L., Morris, B., ...., Tuthill, J. C., Lee, W. A., Card, G. M., Costa, M., Jefferis, G., Eichler, K. (2025). Comparative connectomics of Drosophila descending and ascending neurons. Nature, 643(8070):158-172 www.nature.com/articles/s41...