The Interactive Fly
@interactivefly.bsky.social
The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior
Nemat, R. A., Chaya, T., Atheby, A. C., Lawal, H. O. (2025). Altered Vesicular Acetylcholine Transporter Expression Regulates Acetylcholine Abundance in the Brain of Drosophila melanogaster. J Neurochem, 169(6):e70109 onlinelibrary.wiley.com/doi/10.1111/...
Altered Vesicular Acetylcholine Transporter Expression Regulates Acetylcholine Abundance in the Brain of Drosophila melanogaster
The vesicular acetylcholine transporter (VAChT) packages and transports the neurotransmitter acetylcholine (ACh) into synaptic vesicles for exocytosis, and its activity is necessary for essential lif...
onlinelibrary.wiley.com
November 25, 2025 at 4:54 PM
Nemat, R. A., Chaya, T., Atheby, A. C., Lawal, H. O. (2025). Altered Vesicular Acetylcholine Transporter Expression Regulates Acetylcholine Abundance in the Brain of Drosophila melanogaster. J Neurochem, 169(6):e70109 onlinelibrary.wiley.com/doi/10.1111/...
Lee, G. G., Peterson, A. J.,.., O'Connor, M., Park, J. H. (2025). Linking expression and function of Drosophila type-I TGF-β receptor baboon isoforms: Multiple roles of BaboA isoform in shaping of the adult central nervous system. PLoS One, 20(5):e0318406 journals.plos.org/plosone/arti...
Linking expression and function of Drosophila type-I TGF-β receptor baboon isoforms: Multiple roles of BaboA isoform in shaping of the adult central nervous system
Evolutionarily conserved transforming growth factor β (TGF-β) signaling is used in both vertebrates and invertebrates to regulate a variety of developmental and cellular processes. The baboon (babo) g...
journals.plos.org
November 25, 2025 at 4:53 PM
Lee, G. G., Peterson, A. J.,.., O'Connor, M., Park, J. H. (2025). Linking expression and function of Drosophila type-I TGF-β receptor baboon isoforms: Multiple roles of BaboA isoform in shaping of the adult central nervous system. PLoS One, 20(5):e0318406 journals.plos.org/plosone/arti...
Pang, R., Baker, C. A., Murthy, M., Pillow, J. (2025). Inferring neural population codes for Drosophila acoustic communication. Proc Natl Acad Sci U S A, 122(21):e2417733122 www.pnas.org/doi/10.1073/...
Inferring neural population codes for Drosophila acoustic communication | PNAS
Social communication between animals is often mediated by sequences of acoustic signals,
sometimes spanning long timescales. How auditory neural ci...
www.pnas.org
November 25, 2025 at 4:51 PM
Pang, R., Baker, C. A., Murthy, M., Pillow, J. (2025). Inferring neural population codes for Drosophila acoustic communication. Proc Natl Acad Sci U S A, 122(21):e2417733122 www.pnas.org/doi/10.1073/...
Guttenplan, K. A., Maxwell, I., Santos, E., Borchardt, L. A., Manzo, E., Abalde-Atristain, L., Kim, R., Freeman, M. R. (2025). GPCR signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity. Science, 388(6748):763-768 www.science.org/doi/10.1126/...
GPCR signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity
How astrocytes regulate neuronal circuits is a fundamental question in neurobiology. Specifically, how astrocytes respond to different neurotransmitters in vivo and how they affect downstream circuit ...
www.science.org
November 25, 2025 at 4:50 PM
Guttenplan, K. A., Maxwell, I., Santos, E., Borchardt, L. A., Manzo, E., Abalde-Atristain, L., Kim, R., Freeman, M. R. (2025). GPCR signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity. Science, 388(6748):763-768 www.science.org/doi/10.1126/...
Thakur, D., Hunt, S., Tsou, T., Petty, M., Rodriguez, J. M., Montell, C. (2025). Control of odor sensation by light and cryptochrome in the Drosophila antenna. iScience, 28(5):112443 www.cell.com/iscience/ful...
Control of odor sensation by light and cryptochrome in the Drosophila antenna
Entomology; Neuroscience; Sensory neuroscience
www.cell.com
November 25, 2025 at 4:48 PM
Thakur, D., Hunt, S., Tsou, T., Petty, M., Rodriguez, J. M., Montell, C. (2025). Control of odor sensation by light and cryptochrome in the Drosophila antenna. iScience, 28(5):112443 www.cell.com/iscience/ful...
Tenedini, F. M., Yin, C., Huang, J. M., Dhiman, N., Soba, P., Parrish, J. Z. (2025). Inflammatory cytokine upd3 induces axon length-dependent synapse removal by glia. Proc Natl Acad Sci U S A, 122(21):e2422752122 www.pnas.org/doi/10.1073/...
November 25, 2025 at 4:47 PM
Tenedini, F. M., Yin, C., Huang, J. M., Dhiman, N., Soba, P., Parrish, J. Z. (2025). Inflammatory cytokine upd3 induces axon length-dependent synapse removal by glia. Proc Natl Acad Sci U S A, 122(21):e2422752122 www.pnas.org/doi/10.1073/...
Ranxhi, B., Bangash, Z., Chbihi, Z. M., Qadri, Z., Islam, N. N., Todi, S. V., LeWitt, P. A., Tsou, W. L. (2025). Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson's Disease. Res Sq, pubmed.ncbi.nlm.nih.gov/40470180/
November 25, 2025 at 12:59 AM
Ranxhi, B., Bangash, Z., Chbihi, Z. M., Qadri, Z., Islam, N. N., Todi, S. V., LeWitt, P. A., Tsou, W. L. (2025). Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson's Disease. Res Sq, pubmed.ncbi.nlm.nih.gov/40470180/
Pasam, E. S., Madamanchi, K., Melkani, G. C. (2025). Dissecting Metabolic Control of Behaviors and Physiology During Aging in Drosophila. Res Sq, www.researchsquare.com/article/rs-6...
November 25, 2025 at 12:58 AM
Pasam, E. S., Madamanchi, K., Melkani, G. C. (2025). Dissecting Metabolic Control of Behaviors and Physiology During Aging in Drosophila. Res Sq, www.researchsquare.com/article/rs-6...
Tan, F. H. P., Azzam, G., Najimudin, N., Shamsuddin, S., Zainuddin, A., Kasihmuddin, M. S. M. (2025). Salvianolic acid B ameliorates Aβ42 toxicity in Aβ42-expressing Drosophila model: behavioral and transcriptomic profiling. Metab Brain Dis, 40(5):204 link.springer.com/article/10.1...
Salvianolic acid B ameliorates Aβ42 toxicity in Aβ42-expressing Drosophila model: behavioral and transcriptomic profiling - Metabolic Brain Disease
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases worldwide. It is characterized by the accumulation of amyloid-beta (Aβ) plaques in which Aβ42 is the most toxic and aggres...
link.springer.com
November 25, 2025 at 12:57 AM
Tan, F. H. P., Azzam, G., Najimudin, N., Shamsuddin, S., Zainuddin, A., Kasihmuddin, M. S. M. (2025). Salvianolic acid B ameliorates Aβ42 toxicity in Aβ42-expressing Drosophila model: behavioral and transcriptomic profiling. Metab Brain Dis, 40(5):204 link.springer.com/article/10.1...
Modafferi, S., Farina, S., Esposito, F., Brandi, O., ...., d'Adda di Fagagna, F., Gioia, U., Francia, S. (2025). DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue. Cell Death Differ, www.nature.com/articles/s41...
DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue - Cell Death & Differentiation
Cell Death & Differentiation - DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue
www.nature.com
November 25, 2025 at 12:56 AM
Modafferi, S., Farina, S., Esposito, F., Brandi, O., ...., d'Adda di Fagagna, F., Gioia, U., Francia, S. (2025). DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue. Cell Death Differ, www.nature.com/articles/s41...
Martin-Carrascosa, M. D. C., Palacios-Martinez, C., Galindo, M. I. (2025). A phylogenetic analysis of the CDKL protein family unravels its evolutionary history and supports the Drosophila model of CDKL5 deficiency disorder. Front Cell Dev Biol, 13:1582684 www.frontiersin.org/journals/cel...
Frontiers | A phylogenetic analysis of the CDKL protein family unravels its evolutionary history and supports the Drosophila model of CDKL5 deficiency disorder
The human CDK-like (CDKL) family of serine‒threonine kinases has five members (CDKL1-5), with a conserved N-terminal kinase domain and variable C-termini. Am...
www.frontiersin.org
November 25, 2025 at 12:54 AM
Martin-Carrascosa, M. D. C., Palacios-Martinez, C., Galindo, M. I. (2025). A phylogenetic analysis of the CDKL protein family unravels its evolutionary history and supports the Drosophila model of CDKL5 deficiency disorder. Front Cell Dev Biol, 13:1582684 www.frontiersin.org/journals/cel...
Park, Y. J., Lu, T. C., Jackson, T., Goodman, L. D., ...., Zheng, H., Qi, Y., Bellen, H. J., Li, H. (2025). Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq. Neuron, 113(13):2065-2082 www.cell.com/neuron/abstr...
Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq
Park and Lu et al. create a whole-organism Alzheimer’s disease (AD) Fly Cell Atlas
to reveal how AD-associated proteins systemically affect the brain and body. Their
work uncovers distinct effects of ...
www.cell.com
November 25, 2025 at 12:52 AM
Park, Y. J., Lu, T. C., Jackson, T., Goodman, L. D., ...., Zheng, H., Qi, Y., Bellen, H. J., Li, H. (2025). Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq. Neuron, 113(13):2065-2082 www.cell.com/neuron/abstr...
Moon, M., Yun, J., Pyeon, M., Yun, J., Yang, J., Yeom, H. D., Lee, G., Choi, Y., Lee, J., Lee, J. H. (2025). Phenethyl Acetate as an Agonist of Insect Odorant Receptor Co-Receptor (Orco): Molecular Mechanisms and Functional Insights. Int J Mol Sci, 26(11) www.mdpi.com/1422-0067/26...
November 21, 2025 at 10:15 PM
Moon, M., Yun, J., Pyeon, M., Yun, J., Yang, J., Yeom, H. D., Lee, G., Choi, Y., Lee, J., Lee, J. H. (2025). Phenethyl Acetate as an Agonist of Insect Odorant Receptor Co-Receptor (Orco): Molecular Mechanisms and Functional Insights. Int J Mol Sci, 26(11) www.mdpi.com/1422-0067/26...
Okasha, M., Chen, J., Ayekoi, A., Jacob, E., Radtke, V., Schmidt, A., Bacher, A., Weber, S., Schleicher, E. (2025). Linear free energy relationship between reduction potential and photoreduction rate: studies on Drosophila cryptochrome. Febs j, febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
A series of modified FAD cofactors have been used to modulate the photochemistry of FAD-containing cryptochrome. When 7-halogenated FADs were used, a significantly faster signaling-state formation wa...
febs.onlinelibrary.wiley.com
November 21, 2025 at 10:14 PM
Okasha, M., Chen, J., Ayekoi, A., Jacob, E., Radtke, V., Schmidt, A., Bacher, A., Weber, S., Schleicher, E. (2025). Linear free energy relationship between reduction potential and photoreduction rate: studies on Drosophila cryptochrome. Febs j, febs.onlinelibrary.wiley.com/doi/10.1111/...
Kim, K. Y., Hwang, Y. L., Yeom, S., Kwon, S. H., Jeon, S. H. (2025). Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD. Dev Dyn, anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
November 21, 2025 at 10:12 PM
Kim, K. Y., Hwang, Y. L., Yeom, S., Kwon, S. H., Jeon, S. H. (2025). Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD. Dev Dyn, anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
Fletcher, S. J., Bardossy, E., Tome-Poderti, L., Moss, T., Mongelli, V., Frangeul, L., Blanc, H., Verdier, Y., Vinh, J., Mukherjee, S., Saleh, M. C. (2025). Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila. Sci Adv, 11(20):eadv1286 www.science.org/doi/10.1126/...
Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila
Hsc70-4 localizes to the cell surface of Drosophila cells, binds to exogenous dsRNA, and mediates its internalization.
www.science.org
November 21, 2025 at 10:11 PM
Fletcher, S. J., Bardossy, E., Tome-Poderti, L., Moss, T., Mongelli, V., Frangeul, L., Blanc, H., Verdier, Y., Vinh, J., Mukherjee, S., Saleh, M. C. (2025). Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila. Sci Adv, 11(20):eadv1286 www.science.org/doi/10.1126/...
Krishnan, H., Muzaffar, S., Sharma, S., Ramya, V., Ghosh, A., Sowdhamini, R., Padinjat, R. (2025). Conserved biochemical activity and function of phosphatidylinositol 5 phosphate 4 kinase regulates growth & development. Cell Sci, journals.biologists.com/jcs/article-...
November 21, 2025 at 10:08 PM
Krishnan, H., Muzaffar, S., Sharma, S., Ramya, V., Ghosh, A., Sowdhamini, R., Padinjat, R. (2025). Conserved biochemical activity and function of phosphatidylinositol 5 phosphate 4 kinase regulates growth & development. Cell Sci, journals.biologists.com/jcs/article-...
Hu, J., Li, X., Lomaev, D., Vorobyeva, N. E., Levine, M., Erokhin, M., Chetverina, D. (2025). Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain. Mol Cell, 85(12):2442-2451 www.cell.com/molecular-ce...
Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain
In Drosophila, tethering elements are DNA regulatory regions that facilitate long-range
interactions between enhancers and promoters as well as between the promoters of distant
paralogous genes. Hu et...
www.cell.com
November 21, 2025 at 10:06 PM
Hu, J., Li, X., Lomaev, D., Vorobyeva, N. E., Levine, M., Erokhin, M., Chetverina, D. (2025). Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain. Mol Cell, 85(12):2442-2451 www.cell.com/molecular-ce...
Huang, R. N., Luo, S. Y., Huang, T., ...., Li, L. Y., Tang, B., Qiao, J. D. (2025). The interaction of UBR4, LRP1, and OPHN1 in refractory epilepsy: Drosophila model to investigate the oligogenic effect on epilepsy. Neurobiol Dis, 212:106955 www.sciencedirect.com/science/arti...
November 19, 2025 at 11:20 PM
Huang, R. N., Luo, S. Y., Huang, T., ...., Li, L. Y., Tang, B., Qiao, J. D. (2025). The interaction of UBR4, LRP1, and OPHN1 in refractory epilepsy: Drosophila model to investigate the oligogenic effect on epilepsy. Neurobiol Dis, 212:106955 www.sciencedirect.com/science/arti...
Li, J., Song, J., Yan, B., Wu, H., ...., Jia, J., Weiss, H. L., Evers, B. M. (2025). Neurotensin inhibits AMPK activity and enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging. Exp Mol Med, 57(6):1189-1201 www.nature.com/articles/s12...
Neurotensin inhibits AMPK activity and concurrently enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging - Experimental & Molecular Medicine
Neurotensin (NTS) is a hormone primarily localized to the gut and brain that affects various bodily functions. Researchers have found that high levels of a form of NTS, called pro-NTS, are linked to d...
www.nature.com
November 19, 2025 at 11:18 PM
Li, J., Song, J., Yan, B., Wu, H., ...., Jia, J., Weiss, H. L., Evers, B. M. (2025). Neurotensin inhibits AMPK activity and enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging. Exp Mol Med, 57(6):1189-1201 www.nature.com/articles/s12...
Marnas, P., Lupold, S., ..., Zarogiannis, S., Rouka, E. (2025). Modeling COPD in Drosophila by cigarette smoke: functional changes and alterations in the expression of COPD-relevant orthologous genes. Am J Physiol Regul Integr Comp Physiol, 329(1):R13-r19 journals.physiology.org/doi/full/10....
November 19, 2025 at 11:16 PM
Marnas, P., Lupold, S., ..., Zarogiannis, S., Rouka, E. (2025). Modeling COPD in Drosophila by cigarette smoke: functional changes and alterations in the expression of COPD-relevant orthologous genes. Am J Physiol Regul Integr Comp Physiol, 329(1):R13-r19 journals.physiology.org/doi/full/10....
Long, J., Jones, S. G., Serna, A., ..., Verstreken, P., Huynen, M. A., Luhy, K., Coll-Tane, M., Schenck, A. (2025). A conserved epilepsy-associated gene co-expression module identifies increased metabolic rate as a shared pathomechanism. Dis Model Mech, journals.biologists.com/dmm/article/...
November 19, 2025 at 11:09 PM
Long, J., Jones, S. G., Serna, A., ..., Verstreken, P., Huynen, M. A., Luhy, K., Coll-Tane, M., Schenck, A. (2025). A conserved epilepsy-associated gene co-expression module identifies increased metabolic rate as a shared pathomechanism. Dis Model Mech, journals.biologists.com/dmm/article/...
Jiang, H., Satoh, Y., Yamamura, R., Ooshio, T., ...., Hirata, T., Osawa, T., Goda, K., Sonoshita, M. (2025). Inhibition of NAD-GPx4 axis and MEK triggers ferroptosis to suppress pancreatic ductal adenocarcinoma. Mol Ther, www.cell.com/molecular-th...
Inhibition of NAD-GPx4 axis and MEK triggers ferroptosis to suppress pancreatic ductal adenocarcinoma
This study using Drosophila and mammalian models revealed that dual inhibition of
GPx4 and MEK induces ferroptosis in pancreatic cancer by promoting iron accumulation
and oxidative stress, highlightin...
www.cell.com
November 19, 2025 at 11:02 PM
Jiang, H., Satoh, Y., Yamamura, R., Ooshio, T., ...., Hirata, T., Osawa, T., Goda, K., Sonoshita, M. (2025). Inhibition of NAD-GPx4 axis and MEK triggers ferroptosis to suppress pancreatic ductal adenocarcinoma. Mol Ther, www.cell.com/molecular-th...
Liu, Z., Du, G., Chen, Y., Chen, H. (2025). Age-associated decline of Coenzyme A leads to intestinal stem cells dysfunction via disturbing iron homeostasis. PLoS Genet, 21(6):e1011704 journals.plos.org/plosgenetics...
Age-associated decline of Coenzyme A leads to intestinal stem cells dysfunction via disturbing iron homeostasis
Author summary In our study, we explored the connection between the aging of adult stem cells and the rise of age-related diseases, uncovering a significant metabolic link. As stem cells age, a key me...
journals.plos.org
November 19, 2025 at 11:00 PM
Liu, Z., Du, G., Chen, Y., Chen, H. (2025). Age-associated decline of Coenzyme A leads to intestinal stem cells dysfunction via disturbing iron homeostasis. PLoS Genet, 21(6):e1011704 journals.plos.org/plosgenetics...
Reposted by The Interactive Fly
📢Check out our latest #preprint list on FocalPlane
This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one!
focalplane.biologists.com/2025/11/14/m...
This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one!
focalplane.biologists.com/2025/11/14/m...
Microscopy preprints – bioimage analysis - FocalPlane
Microscopy preprints – bioimage analysis - News
focalplane.biologists.com
November 18, 2025 at 10:07 AM
📢Check out our latest #preprint list on FocalPlane
This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one!
focalplane.biologists.com/2025/11/14/m...
This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one!
focalplane.biologists.com/2025/11/14/m...