Hotblack
@invalid-handle.com
Will talk science, tech, economics, politics
Mainly post stupid puns and captions for pictures
Cares about inequalities and exclusion, particularly around health
Enjoys cricket
Mainly post stupid puns and captions for pictures
Cares about inequalities and exclusion, particularly around health
Enjoys cricket
Pinned
Hotblack
@invalid-handle.com
· Sep 21
An invalid with a handle that was invalid so now has the handle invalid handle
Stormy Daniels never revealed Trump’s real kink… Fiscal dominance
January 13, 2026 at 11:57 AM
Stormy Daniels never revealed Trump’s real kink… Fiscal dominance
I bet he’s got a gravelly purr
January 12, 2026 at 8:29 PM
I bet he’s got a gravelly purr
I propose enforced hibernation for all humans in the northern hemisphere until we can be trusted not to break things
January 12, 2026 at 1:02 PM
I propose enforced hibernation for all humans in the northern hemisphere until we can be trusted not to break things
*checks news*
oh
*checks timeline*
oh ffs
you leave the world alone for a few weeks and look what happens…
oh
*checks timeline*
oh ffs
you leave the world alone for a few weeks and look what happens…
January 12, 2026 at 12:51 PM
*checks news*
oh
*checks timeline*
oh ffs
you leave the world alone for a few weeks and look what happens…
oh
*checks timeline*
oh ffs
you leave the world alone for a few weeks and look what happens…
Reposted by Hotblack
The CureME team at @lshtm.bsky.social are looking for healthy volunteers aged 18–60 to give blood twice with a six month interval to act as controls for a study into ME/CFS
If you’re around London and interested please email [email protected]
If you’re around London and interested please email [email protected]
January 6, 2026 at 12:34 PM
The CureME team at @lshtm.bsky.social are looking for healthy volunteers aged 18–60 to give blood twice with a six month interval to act as controls for a study into ME/CFS
If you’re around London and interested please email [email protected]
If you’re around London and interested please email [email protected]
The CureME team at @lshtm.bsky.social are looking for healthy volunteers aged 18–60 to give blood twice with a six month interval to act as controls for a study into ME/CFS
If you’re around London and interested please email [email protected]
If you’re around London and interested please email [email protected]
January 6, 2026 at 12:34 PM
The CureME team at @lshtm.bsky.social are looking for healthy volunteers aged 18–60 to give blood twice with a six month interval to act as controls for a study into ME/CFS
If you’re around London and interested please email [email protected]
If you’re around London and interested please email [email protected]
Reposted by Hotblack
1) We’ve just published our review of the most interesting ME/CFS studies of 2025.
It feels like this year, we’ve made a significant step towards understanding the pathophysiology of ME/CFS.
A brief overview of the studies that caught our eye.
It feels like this year, we’ve made a significant step towards understanding the pathophysiology of ME/CFS.
A brief overview of the studies that caught our eye.
December 30, 2025 at 11:02 AM
1) We’ve just published our review of the most interesting ME/CFS studies of 2025.
It feels like this year, we’ve made a significant step towards understanding the pathophysiology of ME/CFS.
A brief overview of the studies that caught our eye.
It feels like this year, we’ve made a significant step towards understanding the pathophysiology of ME/CFS.
A brief overview of the studies that caught our eye.
Merry Christmas everyone, hope you enjoy, however you’re spending the next few days
December 24, 2025 at 1:04 PM
Merry Christmas everyone, hope you enjoy, however you’re spending the next few days
Reposted by Hotblack
1) New factsheet: ME/CFS - information for medical professionals (6 pages).
Written by Prof. Emeritus Jonathon Edwards and members of the Science for ME forum. A valuable text, useful to bookmark. A couple of quotes from key paragraphs 👇
Written by Prof. Emeritus Jonathon Edwards and members of the Science for ME forum. A valuable text, useful to bookmark. A couple of quotes from key paragraphs 👇
December 15, 2025 at 8:47 AM
1) New factsheet: ME/CFS - information for medical professionals (6 pages).
Written by Prof. Emeritus Jonathon Edwards and members of the Science for ME forum. A valuable text, useful to bookmark. A couple of quotes from key paragraphs 👇
Written by Prof. Emeritus Jonathon Edwards and members of the Science for ME forum. A valuable text, useful to bookmark. A couple of quotes from key paragraphs 👇
Thanks Ben, appreciated 😊
December 11, 2025 at 4:23 PM
Thanks Ben, appreciated 😊
Reposted by Hotblack
Delighted how @precisionlife.bsky.social and @actionforme.bsky.social et al used consented @decodemestudy.bsky.social data to
-replicate #MEcfs genetic signal &
-show its shared/distinct genetics with Long Covid.
Next: replicate ME/CFS subtypes w/ targeted therapies
www.medrxiv.org/content/10.6...
-replicate #MEcfs genetic signal &
-show its shared/distinct genetics with Long Covid.
Next: replicate ME/CFS subtypes w/ targeted therapies
www.medrxiv.org/content/10.6...
Identification of Novel Reproducible Combinatorial Genetic Risk Factors for Myalgic Encephalomyelitis in the DecodeME Patient Cohort and Commonalities with Long COVID
Background: Myalgic encephalomyelitis (also known as ME/CFS or simply ME) has severely impacted the lives of tens of millions of people globally, but the disease currently has no accurate diagnostic t...
www.medrxiv.org
December 4, 2025 at 8:13 AM
Delighted how @precisionlife.bsky.social and @actionforme.bsky.social et al used consented @decodemestudy.bsky.social data to
-replicate #MEcfs genetic signal &
-show its shared/distinct genetics with Long Covid.
Next: replicate ME/CFS subtypes w/ targeted therapies
www.medrxiv.org/content/10.6...
-replicate #MEcfs genetic signal &
-show its shared/distinct genetics with Long Covid.
Next: replicate ME/CFS subtypes w/ targeted therapies
www.medrxiv.org/content/10.6...
HRH* Hotblack
*health related hiatus
*health related hiatus
December 2, 2025 at 1:03 PM
HRH* Hotblack
*health related hiatus
*health related hiatus
Reposted by Hotblack
The world is full of suffering. Recognize this truth, first within yourself. Then, extend that understanding—that *humanity*—to everyone you encounter. Be patient. Be kind.
November 18, 2025 at 7:48 PM
The world is full of suffering. Recognize this truth, first within yourself. Then, extend that understanding—that *humanity*—to everyone you encounter. Be patient. Be kind.
Reposted by Hotblack
My notes on Gemini 3, including analyzing a 3.5 hour council meeting audio recording and performance on a new, improved version of my pelican on a bicycle benchmark simonwillison.net/2025/Nov/18/...
Trying out Gemini 3 Pro with audio transcription and a new pelican benchmark
Google released Gemini 3 Pro today. Here’s the announcement from Sundar Pichai, Demis Hassabis, and Koray Kavukcuoglu, their developer blog announcement from Logan Kilpatrick, the Gemini 3 Pro Model C...
simonwillison.net
November 18, 2025 at 7:09 PM
My notes on Gemini 3, including analyzing a 3.5 hour council meeting audio recording and performance on a new, improved version of my pelican on a bicycle benchmark simonwillison.net/2025/Nov/18/...
Like anyone believes he’s in the driver’s seat
…or giving clear directions
…or giving clear directions
November 18, 2025 at 5:30 PM
Like anyone believes he’s in the driver’s seat
…or giving clear directions
…or giving clear directions
Keir Starmer has warned his team that he’ll turn off the router so they can’t play Fortnite if they keep on arguing
Keir Starmer has warned senior ministers & officials to stop briefing against one another & leaking details of budget
PM told cabinet last week’s political turmoil distracted from voters’ priorities & they shld focus on delivery not navel gazing 👇
www.theguardian.com/politics/202...
PM told cabinet last week’s political turmoil distracted from voters’ priorities & they shld focus on delivery not navel gazing 👇
www.theguardian.com/politics/202...
Starmer pleads for government to unite in fightback after difficult week
Prime minister tells cabinet budget leaks and infighting are distracting from priorities and delivering change
www.theguardian.com
November 18, 2025 at 5:09 PM
Keir Starmer has warned his team that he’ll turn off the router so they can’t play Fortnite if they keep on arguing
Oh dear 😬
I had a phone that would just give up and turn itself off whenever anyone called. It was quite nice in a way but yeah, not conducive to getting a new job
I had a phone that would just give up and turn itself off whenever anyone called. It was quite nice in a way but yeah, not conducive to getting a new job
November 18, 2025 at 5:05 PM
Oh dear 😬
I had a phone that would just give up and turn itself off whenever anyone called. It was quite nice in a way but yeah, not conducive to getting a new job
I had a phone that would just give up and turn itself off whenever anyone called. It was quite nice in a way but yeah, not conducive to getting a new job
Like two stars trapped in an orbit around a black hole…
November 18, 2025 at 5:01 PM
Like two stars trapped in an orbit around a black hole…
Reposted by Hotblack
Pelican Riding a Bike 🚲
November 18, 2025 at 4:18 PM
Pelican Riding a Bike 🚲
All good things come to those who wait… sometimes :)
November 18, 2025 at 4:50 PM
All good things come to those who wait… sometimes :)
Disappointingly, after enabling it in Gemini CLI it says I have exhausted my daily quota on this model. So I guess its not available to Free Tier users yet
November 18, 2025 at 4:45 PM
Disappointingly, after enabling it in Gemini CLI it says I have exhausted my daily quota on this model. So I guess its not available to Free Tier users yet