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Irina Bezsonova @irinabezsonova.bsky.social · 4h

🤔

Irina Bezsonova @irinabezsonova.bsky.social · 5h

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 9
Prompt HEAVY
Pdb: 4DL6

Heavy metal therapy. Platinum-based cancer drug cisplatin damages DNA but DNA polymerase eta manages to copy it past the lesion.

Next: SWEEP
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 17h

Thank you

Irina Bezsonova @irinabezsonova.bsky.social · 1d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 8
Prompt RECKLESS
Pdb: 5TZO

A reckless surge. Two molecules of fentanyl engulfed by its computationally designed binder Fen49*

Next: HEAVY
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 1d

Week 1 of first drafts :)

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Irina Bezsonova @irinabezsonova.bsky.social · 2d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 7
Prompt STARFISH
Pdb: 6KG7

Starfish relies on sensory information.
This is Piezo 2 - mechanically activated ion channel responsible for the sense of touch.

Next: RECKLESS
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 2d

Thanks!

Irina Bezsonova @irinabezsonova.bsky.social · 3d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 6
Prompt PIERCE
Pdb: 8HO3 8HQO 8HQZ 8HRE 8HRG

Structure of a bacteriophage DT57C that carries a special piercing tip to attack bacteria.

Next: STARFISH
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 3d

You know, I agree. How about in 2027 we feature ubiquitin in all prompts? Maybe an occasional E3 or a DUB :)

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Irina Bezsonova @irinabezsonova.bsky.social · 4d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 5
Prompt DEER
Pdb 4YXH

Two molecules of a deer prion protein decorate its head. Misfolded prions can make other prions to misfold causing neurodegenerative diseases in mammals.

Next: PIERCE
Suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 4d

I’m glad you approve! Any ideas for deer?

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Irina Bezsonova @irinabezsonova.bsky.social · 5d

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 4
Prompt MURKY
Pdb 8T1M

Domain with unidentified function 1842 from pathogenic bacteria (thanks Leah)

There are many proteins with known structures but their function remains murky.

Next DEER

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Irina Bezsonova @irinabezsonova.bsky.social · 5d

Love this!

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Irina Bezsonova @irinabezsonova.bsky.social · 6d

This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 3/31
Prompt CROWN

Coronavirus spike protein. The crown sits on one of its three receptor-binding domains - a key element for successful infection.

Pdb: 6ZWV

Next prompt is MURKY and I’m at loss

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Irina Bezsonova @irinabezsonova.bsky.social · 7d

This October I’m drawing one molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 2/31
Prompt WEAVE

N-terminal domain of a Fibrion - a building block of silk fiber produced by silkworms.

Pdb: 3UA0

Next prompt is CROWN and I would love your suggestions!

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Irina Bezsonova @irinabezsonova.bsky.social · 8d

What a great suggestion!

Irina Bezsonova @irinabezsonova.bsky.social · 8d

Thanks, will take a look.

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Irina Bezsonova @irinabezsonova.bsky.social · 8d

Thanks, Jonathan.

Irina Bezsonova @irinabezsonova.bsky.social · 8d

This October I’m drawing one molecule a day inspired by proteins @rcsb.bsky.social

Day 1/31
Prompt MUSTACHE
Pdb 2QZI

Let’s start with something fun:
Mr. Potato head’s ‘stache is made of Androgen Receptor that binds testosterone and helps maintain his male phenotype

Next prompt: WEAVE
suggestions?

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Irina Bezsonova @irinabezsonova.bsky.social · 8d

Got my inktober supplies!

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Irina Bezsonova @irinabezsonova.bsky.social · 10d

I was lucky today to finally have a chance to visit RCSB PDB @rcsbpdb.bsky.social at Rutgers. Special thanks to Stephen Burley for hosting and Jason Kaelber for the tour of the facilities.

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Irina Bezsonova @irinabezsonova.bsky.social · 13d

I see it…

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Irina Bezsonova @irinabezsonova.bsky.social · 13d

You can find my previous inktober works here: pdb101.rcsb.org/sci-art/bezs...

PDB101: Irina Bezsonova Gallery

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

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Irina Bezsonova @irinabezsonova.bsky.social · 13d

It’s almost October!
I plant to participate in inktober challenge again this year. One protein drawing a day for 31 days. I would LOVE your suggestions!
Check out the prompt list and nominate a pdb of a protein for me to draw that could be a good fit for any of these prompts.
Wish me luck!

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Irina Bezsonova @irinabezsonova.bsky.social · 17d

Our latest paper is online today ahead of print in PNAS
@pnas.org

www.pnas.org/doi/10.1073/...

Functional spectrum of USP7 pathogenic variants in Hao–Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation | PNAS

Hao–Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7)...

www.pnas.org

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