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ISSLS @issls.bsky.social · Sep 9

Why join ISSLS?
✔️ Discounted registration
✔️ Access to a truly interdisciplinary, international network
✔️ Eligibility for fellowships, awards, and committee roles
✔️ Voting rights to help shape the future of ISSLS
✔️ Opportunities to contribute to global initiatives, taskforces, and consensus papers

ISSLS @issls.bsky.social · Sep 9

ISSLS membership applications are now open until the 19th of September!

Join our global community of world-class spine researchers, clinicians, surgeons, and more before the deadline closes

📅 Deadline to apply: September 19th
🔗 Learn more and apply: www.issls.org/membership

Why join ISSLS? 👇🏼

MEMBERSHIP APPLICATION — The International Society for the Study of the Lumbar Spine

www.issls.org

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ISSLS @issls.bsky.social · Jul 21

Let’s give a warm welcome to Dr. Mengis! 🫴

💬 Say hi in the comments & connect on LinkedIn:
🔗 www.linkedin.com/in/tamara-me...

Are you also pushing the boundaries of #LumbarSpine research? Join ISSLS and be part of a global community shaping the future of spine science:
🔗 www.issls.org/membership

www.linkedin.com

ISSLS @issls.bsky.social · Jul 21

One of Dr. Mengis's recent impactful studies, published in JCI Insight, investigates immune responses linked to vertebral bone marrow changes, offering promising new perspectives for understanding and treating chronic low back pain.
📖 Read it here: pubmed.ncbi.nlm.nih.gov/38585427/

Intervertebral disc microbiome in Modic changes: Lack of result replication underscores the need for a consensus in low-biomass microbiome analysis - PubMed

There is dysbiosis in MC discs. Bioinformatic parameters impact results yet cannot explain the different findings from this and a previous study. Therefore, discrepancies are likely caused by differen...

pubmed.ncbi.nlm.nih.gov

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ISSLS @issls.bsky.social · Jul 21

Dr. Mengis is a Postdoctoral Researcher at the Center of Experimental Rheumatology, University of Zurich, where she explores the intricate biology of spinal conditions with a focus on Modic changes. Her research highlights the key role of the intervertebral disc in the development of Modic changes.

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ISSLS @issls.bsky.social · Jul 21

🌟 Welcome Dr. Tamara Mengis – Our Newest ISSLS Member! 🌟

We’re excited to welcome Dr. Tamara Mengis, PhD to the #ISSLS community of spine researchers and clinicians!

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ISSLS @issls.bsky.social · Jul 21

The study showed:
➡️ Significant reduction in LBP (VAS scores) in the BM-MSC group
➡️ Improved quality of life and work ability
➡️ Strong safety profile, with no serious adverse events

ISSLS @issls.bsky.social · Jul 21

In this randomized controlled trial, the team investigated the use of autologous bone marrow-derived mesenchymal stromal cells BM- #MSCs to treat patients with chronic low back pain #LBP linked to multilevel intervertebral disc degeneration (IDD).

issls-2025.p.asnevents.com.au/days/2025-05...

Oral Presentation — ASN Events

issls-2025.p.asnevents.com.au

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ISSLS @issls.bsky.social · Jul 21

🎉 Congratulations to the 2025 ISSLS Best Paper Award Winner! 🎉

We are thrilled to spotlight some of the most compelling research in #LumbarSpine science and clinical innovation.

This year’s Best Paper Award was to Prof. Gianluca Vadalà et al of the Università Campus Bio-Medico di Roma

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ISSLS @issls.bsky.social · Jul 9

In Memoriam of Dr. Margareta Nordin (1945–2025)

Please read the beautiful obituary by Dino Samartzis and Björn Rydevik in the #EuropeanSpineJournal here: 🔗 link.springer.com/article/10.1...

ISSLS @issls.bsky.social · May 15

We’re already halfway through ISSLS 2025! 😲

From cutting-edge research to truly inspiring discussions, the energy here is amazing. #ISSLS2025

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ISSLS @issls.bsky.social · May 14

Great special poster session this morning #ISSLS2025 on #IVD degeneration chaired by Stefan Dudli and Kotaro Nishida

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ISSLS @issls.bsky.social · May 13

Presenters are getting robust and constructive questioning here very much in the spirit of #ISSLS2025! Halfway through a great session here including studies on #Modicchanges and deep learning spine variables extracted from UK biobank

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ISSLS @issls.bsky.social · May 13

#ISSLS2025 has officially kicked off here in Atlanta with the basic science session!

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ISSLS @issls.bsky.social · Apr 10

Preoperative #SleepDisturbances and #Depression independently and jointly predict higher disability and pain 12 months after lumbar #SpineSurgery.

The latest publication in Spine by #ISSLS member Kristin R. Archer and team: journals.lww.com/spinejournal...

The Combined Influence of Sleep Disturbance and Depression... : Spine

havioral factors are considered major risk factors for poor outcomes after LSS. However, there is a need to explore the combined effects of preoperative factors such as sleep disturbance and depressio...

journals.lww.com

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ISSLS @issls.bsky.social · Apr 10

The latest publication in The Spine Journal by Todd Alamin investigates patient acceptance of reoperation risk following lumbar decompression and fusion surgeries, revealing some important findings that could impact the future of #LumbarSpine research.

www.thespinejournalonline.com/article/S152...

Patient acceptance of reoperation risk for lumbar decompression versus fusion

Lumbar decompression and lumbar fusion are effective methods of treating spinal compressive pathologies refractory to conservative management. These surgeries are typically used to treat different spi...

www.thespinejournalonline.com

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ISSLS @issls.bsky.social · Apr 10

This research provides valuable insights into the role of mitochondrial oxidative stress in disc degeneration and highlights potential therapeutic strategies for low back pain interventions. Read the full study here: www.sciencedirect.com/science/arti...

SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential

Low back pain (LBP) is a pervasive global health concern, primarily associated with intervertebral disc (IVD) degeneration. Although oxidative stress …

www.sciencedirect.com

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ISSLS @issls.bsky.social · Apr 10

Check out his latest study in #RedoxBiology! His work sheds light on how #OxidativeStress contributes to intervertebral disc degeneration and explores the therapeutic potential of targeting superoxide dismutase 2 to restore redox homeostasis in the disc.

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ISSLS @issls.bsky.social · Apr 10

🌟 Introducing Dr. Shota Tamagawa – Our Newest ISSLS Member! 🌟

ISSLS is thrilled to welcome Shota Tamagawa, MD, PhD, Assistant Professor at Juntendo University Faculty of Medicine, Tokyo, Japan, to our #ISSLS community of spine researchers and clinicians!

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ISSLS @issls.bsky.social · Apr 10

One of his recent studies uses deep learning to analyze MRI data, revealing how lumbar muscle cross-sectional area and fat infiltration vary by sex, age, and clinical condition. Read their complete work here: link.springer.com/article/10.1...

Cross-sectional area and fat infiltration of the lumbar spine muscles in patients with back disorders: a deep learning-based big data analysis - European Spine Journal

Purpose Validated deep learning models represent a valuable option to perform large-scale research studies aiming to evaluate muscle quality and quantity of paravertebral lumbar muscles at the populat...

link.springer.com

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ISSLS @issls.bsky.social · Apr 10

Dr Jacopo Vitale's work bridges clinical practice and sports science, with a focus on enhancing spine health in individuals with back disorders. Dr Vitale investigates how spinal muscle morphology & function relate to patient-reported outcomes, aiming to optimize recovery & long-term spinal health.

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ISSLS @issls.bsky.social · Apr 10

🌟 Welcome Dr. Jacopo Vitale – Our Newest ISSLS Member! 🌟

Dr. Vitale is a Research Associate at the Spine Centre at Schulthess Klinik in Zürich (Switzerland) and Associate Professor at the Institute of Sports Sciences at University of Physical Culture in Cracow (Poland).

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ISSLS @issls.bsky.social · Apr 10

In this study oral administration of senolytic drugs in a mouse model significantly reduced LBP, eliminated SnCs in intervertebral discs and the spinal cord, decreased inflammatory senescence-associated secretory phenotype factors, improved disc & bone health, & lowered pain marker expression

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ISSLS @issls.bsky.social · Apr 10

Publication in #ScienceAdvances by #ISSLS member Prof. Lisbet Haglund: www.science.org/doi/full/10.... This study investigates the potential of two senolytic drugs in treating #LowBackPain by targeting senescent cells, which accumulate with aging and contribute to #inflammation and degeneration

Senolytic treatment for low back pain

Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord.

www.science.org

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ISSLS @issls.bsky.social · Mar 19

Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus: 🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...

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