Jack - amatica health
@jackamatica.bsky.social
Long COVID brain fog may have a measurable brain energy signal.
A whole brain scan found lower ATP/PCr (ATP = main energy molecule in cells, PCr = fast energy backup) in the cingulate cortex, and in the anterior cingulate, lower values lined up with worse cognitive test scores.
A whole brain scan found lower ATP/PCr (ATP = main energy molecule in cells, PCr = fast energy backup) in the cingulate cortex, and in the anterior cingulate, lower values lined up with worse cognitive test scores.
January 19, 2026 at 12:01 PM
Long COVID brain fog may have a measurable brain energy signal.
A whole brain scan found lower ATP/PCr (ATP = main energy molecule in cells, PCr = fast energy backup) in the cingulate cortex, and in the anterior cingulate, lower values lined up with worse cognitive test scores.
A whole brain scan found lower ATP/PCr (ATP = main energy molecule in cells, PCr = fast energy backup) in the cingulate cortex, and in the anterior cingulate, lower values lined up with worse cognitive test scores.
EBV and MS: a shared T cell target (ANO2).
This study finds about 57% of people with MS have CD4 T cells that react to ANO2.
Some of those T cells also react to EBV EBNA1.
In mice, ANO2-focused T cells were linked to worse MS-like disease.
This study finds about 57% of people with MS have CD4 T cells that react to ANO2.
Some of those T cells also react to EBV EBNA1.
In mice, ANO2-focused T cells were linked to worse MS-like disease.
January 17, 2026 at 12:28 PM
EBV and MS: a shared T cell target (ANO2).
This study finds about 57% of people with MS have CD4 T cells that react to ANO2.
Some of those T cells also react to EBV EBNA1.
In mice, ANO2-focused T cells were linked to worse MS-like disease.
This study finds about 57% of people with MS have CD4 T cells that react to ANO2.
Some of those T cells also react to EBV EBNA1.
In mice, ANO2-focused T cells were linked to worse MS-like disease.
ME/CFS immune cell lines show unusual fat buildup.
One specific membrane fat, PC(O-38:4), is much lower and almost separates ME/CFS from controls.
Many triglycerides, diglycerides, and fatty acids are higher.
A lipid enzyme PTDSS1 is higher too.
Paper by @DanMissailidis & Co
One specific membrane fat, PC(O-38:4), is much lower and almost separates ME/CFS from controls.
Many triglycerides, diglycerides, and fatty acids are higher.
A lipid enzyme PTDSS1 is higher too.
Paper by @DanMissailidis & Co
January 15, 2026 at 12:09 PM
ME/CFS immune cell lines show unusual fat buildup.
One specific membrane fat, PC(O-38:4), is much lower and almost separates ME/CFS from controls.
Many triglycerides, diglycerides, and fatty acids are higher.
A lipid enzyme PTDSS1 is higher too.
Paper by @DanMissailidis & Co
One specific membrane fat, PC(O-38:4), is much lower and almost separates ME/CFS from controls.
Many triglycerides, diglycerides, and fatty acids are higher.
A lipid enzyme PTDSS1 is higher too.
Paper by @DanMissailidis & Co
New research on ME/CFS finds unusual cell signals after exercise.
Tiny packages released by cells (extracellular vesicles) show problems with energy production, an overactive immune system, and cell stress. Let’s break it down in simple terms.
Tiny packages released by cells (extracellular vesicles) show problems with energy production, an overactive immune system, and cell stress. Let’s break it down in simple terms.
January 13, 2026 at 12:13 PM
New research on ME/CFS finds unusual cell signals after exercise.
Tiny packages released by cells (extracellular vesicles) show problems with energy production, an overactive immune system, and cell stress. Let’s break it down in simple terms.
Tiny packages released by cells (extracellular vesicles) show problems with energy production, an overactive immune system, and cell stress. Let’s break it down in simple terms.
New analysis suggests treating COVID-19 right at its entry point (nose & throat) can slow or stop the virus early.
Using simple nasal sprays or gargles (like iodine solution or salt water) early on might lower the risk of severe illness.
Using simple nasal sprays or gargles (like iodine solution or salt water) early on might lower the risk of severe illness.
January 13, 2026 at 7:33 AM
New analysis suggests treating COVID-19 right at its entry point (nose & throat) can slow or stop the virus early.
Using simple nasal sprays or gargles (like iodine solution or salt water) early on might lower the risk of severe illness.
Using simple nasal sprays or gargles (like iodine solution or salt water) early on might lower the risk of severe illness.
For the first time, scientists have reversed advanced Alzheimer’s disease in mice - fully restoring memory and repairing brain damage by targeting the brain’s energy supply.
January 10, 2026 at 12:00 PM
For the first time, scientists have reversed advanced Alzheimer’s disease in mice - fully restoring memory and repairing brain damage by targeting the brain’s energy supply.
Microclots and protein chemical changes: separating pre-COVID POTS, Long COVID, and Long COVID POTS.
Microclot counts were not clearly different after strict stats. Protein amounts barely changed.
But PTMs (chemical changes on proteins) inside microclots differed a lot.
Microclot counts were not clearly different after strict stats. Protein amounts barely changed.
But PTMs (chemical changes on proteins) inside microclots differed a lot.
January 8, 2026 at 4:49 PM
Microclots and protein chemical changes: separating pre-COVID POTS, Long COVID, and Long COVID POTS.
Microclot counts were not clearly different after strict stats. Protein amounts barely changed.
But PTMs (chemical changes on proteins) inside microclots differed a lot.
Microclot counts were not clearly different after strict stats. Protein amounts barely changed.
But PTMs (chemical changes on proteins) inside microclots differed a lot.
Lab-grown mini muscles showed that blood from people with chronic fatigue syndrome (ME/CFS) and Long COVID can directly weaken and damage muscle cells.
The muscles first tried to adapt their energy use, then became fragile and lost strength.
The muscles first tried to adapt their energy use, then became fragile and lost strength.
January 7, 2026 at 4:50 PM
Lab-grown mini muscles showed that blood from people with chronic fatigue syndrome (ME/CFS) and Long COVID can directly weaken and damage muscle cells.
The muscles first tried to adapt their energy use, then became fragile and lost strength.
The muscles first tried to adapt their energy use, then became fragile and lost strength.
New research finds people with ME/CFS have a striking deficiency in vasopressin - a hormone that helps the body retain water.
This could explain common symptoms like constant thirst and dizziness upon standing.
Let's break down the findings.
This could explain common symptoms like constant thirst and dizziness upon standing.
Let's break down the findings.
January 6, 2026 at 1:15 PM
New research finds people with ME/CFS have a striking deficiency in vasopressin - a hormone that helps the body retain water.
This could explain common symptoms like constant thirst and dizziness upon standing.
Let's break down the findings.
This could explain common symptoms like constant thirst and dizziness upon standing.
Let's break down the findings.
Long COVID immune findings from a large clinical trial (STOP-PASC).
Short antiviral (Paxlovid) treatment changed immune signals briefly, but did not improve symptoms.
Across many studies, Long COVID shows a shared pattern of ongoing immune activation.
Short antiviral (Paxlovid) treatment changed immune signals briefly, but did not improve symptoms.
Across many studies, Long COVID shows a shared pattern of ongoing immune activation.
December 17, 2025 at 1:40 PM
Long COVID immune findings from a large clinical trial (STOP-PASC).
Short antiviral (Paxlovid) treatment changed immune signals briefly, but did not improve symptoms.
Across many studies, Long COVID shows a shared pattern of ongoing immune activation.
Short antiviral (Paxlovid) treatment changed immune signals briefly, but did not improve symptoms.
Across many studies, Long COVID shows a shared pattern of ongoing immune activation.
2025 brought big new clues about Long COVID and ME/CFS:
Genes tied to risk, immune and clotting changes, PEM findings, possible blood tests, and brain changes.
Here is an end of year round up in plain language.
Genes tied to risk, immune and clotting changes, PEM findings, possible blood tests, and brain changes.
Here is an end of year round up in plain language.
December 11, 2025 at 3:04 PM
2025 brought big new clues about Long COVID and ME/CFS:
Genes tied to risk, immune and clotting changes, PEM findings, possible blood tests, and brain changes.
Here is an end of year round up in plain language.
Genes tied to risk, immune and clotting changes, PEM findings, possible blood tests, and brain changes.
Here is an end of year round up in plain language.
New research shows major damage in the brain stress system of people with very severe ME/CFS.
The key finding: a near-loss of the neurons that start the cortisol stress response. This helps explain low cortisol and many symptoms.
Let’s break it down in simple language.
The key finding: a near-loss of the neurons that start the cortisol stress response. This helps explain low cortisol and many symptoms.
Let’s break it down in simple language.
December 5, 2025 at 6:00 PM
New research shows major damage in the brain stress system of people with very severe ME/CFS.
The key finding: a near-loss of the neurons that start the cortisol stress response. This helps explain low cortisol and many symptoms.
Let’s break it down in simple language.
The key finding: a near-loss of the neurons that start the cortisol stress response. This helps explain low cortisol and many symptoms.
Let’s break it down in simple language.
New ME genetics study:
using a new way to scan DNA, researchers found over 22,000 repeatable genetic patterns linked to ME, many shared with long COVID. 259 noted as core genes.
Let’s break it down in simplified language.
precisionlife.com/news-and-eve...
using a new way to scan DNA, researchers found over 22,000 repeatable genetic patterns linked to ME, many shared with long COVID. 259 noted as core genes.
Let’s break it down in simplified language.
precisionlife.com/news-and-eve...
December 5, 2025 at 4:36 PM
New ME genetics study:
using a new way to scan DNA, researchers found over 22,000 repeatable genetic patterns linked to ME, many shared with long COVID. 259 noted as core genes.
Let’s break it down in simplified language.
precisionlife.com/news-and-eve...
using a new way to scan DNA, researchers found over 22,000 repeatable genetic patterns linked to ME, many shared with long COVID. 259 noted as core genes.
Let’s break it down in simplified language.
precisionlife.com/news-and-eve...
Mild COVID in monkeys caused long lasting changes in brain and body.
Months later they still had problems with smell and taste, thinking, sleep and heart control.
This looks similar to long COVID in people.
Months later they still had problems with smell and taste, thinking, sleep and heart control.
This looks similar to long COVID in people.
December 5, 2025 at 1:52 PM
Mild COVID in monkeys caused long lasting changes in brain and body.
Months later they still had problems with smell and taste, thinking, sleep and heart control.
This looks similar to long COVID in people.
Months later they still had problems with smell and taste, thinking, sleep and heart control.
This looks similar to long COVID in people.
Whole blood RNA sequencing can identify which high risk COVID 19 patients are most likely to worsen and which ones respond best to sotrovimab.
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
December 4, 2025 at 3:38 PM
Whole blood RNA sequencing can identify which high risk COVID 19 patients are most likely to worsen and which ones respond best to sotrovimab.
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
Anktiva is probably one of the most interesting drugs in trial for Long COVID. It works by raising key immune cells that seem low or poorly functioning in LC condition.
This thread explains what the drug does and why researchers are testing it.
This thread explains what the drug does and why researchers are testing it.
December 2, 2025 at 3:13 PM
Anktiva is probably one of the most interesting drugs in trial for Long COVID. It works by raising key immune cells that seem low or poorly functioning in LC condition.
This thread explains what the drug does and why researchers are testing it.
This thread explains what the drug does and why researchers are testing it.
Igg autoimmunity in Long COVID & ME/CFS:
Research shows that IgG antibodies from Long COVID and ME/CFS patients may have direct effects on healthy cells and animals. Some of these antibodies may trigger pain, fatigue-like changes, and altered cell function.
Research shows that IgG antibodies from Long COVID and ME/CFS patients may have direct effects on healthy cells and animals. Some of these antibodies may trigger pain, fatigue-like changes, and altered cell function.
November 28, 2025 at 1:56 PM
Igg autoimmunity in Long COVID & ME/CFS:
Research shows that IgG antibodies from Long COVID and ME/CFS patients may have direct effects on healthy cells and animals. Some of these antibodies may trigger pain, fatigue-like changes, and altered cell function.
Research shows that IgG antibodies from Long COVID and ME/CFS patients may have direct effects on healthy cells and animals. Some of these antibodies may trigger pain, fatigue-like changes, and altered cell function.
Extremely cool new study reports that people with Long COVID have higher levels of blood particles called extracellular vesicles (EVs). These particles also have more mannose, a type of sugar molecule.
This may allow a device called a GNA lectin filter to remove them. 🧵
This may allow a device called a GNA lectin filter to remove them. 🧵
November 25, 2025 at 3:32 PM
Extremely cool new study reports that people with Long COVID have higher levels of blood particles called extracellular vesicles (EVs). These particles also have more mannose, a type of sugar molecule.
This may allow a device called a GNA lectin filter to remove them. 🧵
This may allow a device called a GNA lectin filter to remove them. 🧵
We will be speaking tonight at 5pm GMT at the Renegade Research roundtable.
We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more
Everyone welcome - sign up:
us06web.zoom.us/webinar/regi...
We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more
Everyone welcome - sign up:
us06web.zoom.us/webinar/regi...
Welcome! You are invited to join a webinar: Amatica Health tests for Clinicians. After registering, you will receive a confirmation email about joining the webinar.
Renegade Research is hosting a clinician's roundtable. Amatica will be discussing their 31 marker results in ME/CFS & Long COVID, their RNA sequencing test, and their mission as a whole, including how...
us06web.zoom.us
November 21, 2025 at 10:53 AM
We will be speaking tonight at 5pm GMT at the Renegade Research roundtable.
We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more
Everyone welcome - sign up:
us06web.zoom.us/webinar/regi...
We will be discussing our mission, our approach, the 31 marker batch 2 results, RNA sequencing, and more
Everyone welcome - sign up:
us06web.zoom.us/webinar/regi...
Study in first episode psychosis found that only patients who improved on amisulpride showed clear changes in blood RNA gene expression could predict response with very high accuracy
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
November 20, 2025 at 4:29 PM
Study in first episode psychosis found that only patients who improved on amisulpride showed clear changes in blood RNA gene expression could predict response with very high accuracy
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID and ME at @amaticahealth
Paper breakdown 🧵
New paper links EBV to Lupus.
In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process
Breakdown 🧵
In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process
Breakdown 🧵
November 19, 2025 at 3:13 PM
New paper links EBV to Lupus.
In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process
Breakdown 🧵
In lupus (SLE), Epstein Barr virus (EBV) infects B cells that react to the body’s own nuclear material. EBV then changes these B cells so they act like antigen presenting cells. This may help drive the autoimmune process
Breakdown 🧵
Study identifies blood and kidney RNA patterns that may help predict which lupus nephritis patients respond to treatment and who may flare later.
A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join:
amaticahealth.com
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join:
amaticahealth.com
Paper breakdown 🧵
November 18, 2025 at 3:11 PM
Study identifies blood and kidney RNA patterns that may help predict which lupus nephritis patients respond to treatment and who may flare later.
A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join:
amaticahealth.com
Paper breakdown 🧵
A similar method to what we aim to do in Long COVID & ME/CFS with @amaticahealth - join:
amaticahealth.com
Paper breakdown 🧵
New research shows the SARS-CoV-2 spike protein alone can trigger an autoimmune attack on ACE2 - the same receptor the virus uses to enter cells - leading to lung and kidney injury even without viral infection.
November 17, 2025 at 3:04 PM
New research shows the SARS-CoV-2 spike protein alone can trigger an autoimmune attack on ACE2 - the same receptor the virus uses to enter cells - leading to lung and kidney injury even without viral infection.
New research shows ME/CFS involves measurable DNA-level changes - including genetic risk factors, mitochondrial dysfunction, oxidative stress, and epigenetic reprogramming - linking it biologically to Long COVID and pointing to new diagnostic and treatment paths.
Let’s break it down🧵
Let’s break it down🧵
November 14, 2025 at 2:09 PM
New research shows ME/CFS involves measurable DNA-level changes - including genetic risk factors, mitochondrial dysfunction, oxidative stress, and epigenetic reprogramming - linking it biologically to Long COVID and pointing to new diagnostic and treatment paths.
Let’s break it down🧵
Let’s break it down🧵
1/ New study tested blood from ME/CFS patients for 185 human viruses.
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
November 13, 2025 at 1:50 PM
1/ New study tested blood from ME/CFS patients for 185 human viruses.
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵
Result: healthy controls had more viral DNA than patients (Unexpected).
Only Varicella Zoster Virus (VZV) appeared more often in ME/CFS, hinting at possible reactivation in a subgroup.
Let’s break it down🧵