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jackkucinski.bsky.social
Jack Kucinski
@jackkucinski.bsky.social
26 followers 58 following 4 posts
Ph.D. Candidate at The Ohio State University and Nationwide Children’s Hospital
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jackkucinski.bsky.social
Jack Kucinski @jackkucinski.bsky.social · Jul 23
I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo
Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1 oncoprotein function...
www.cell.com
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jackkucinski.bsky.social
Jack Kucinski @jackkucinski.bsky.social · Jul 23
Thank you!
jackkucinski.bsky.social
Jack Kucinski @jackkucinski.bsky.social · Jul 23
Last, but certainly not least, this was a fantastic team effort and I appreciate all the support throughout this work! pediatricsnationwide.org/2025/07/22/t.... @nchfordocs.bsky.social @nationwidekids.bsky.social
Transforming the Approach to Cancer Epigenomic Studies – Pediatrics Nationwide
pediatricsnationwide.org
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jackkucinski.bsky.social
Jack Kucinski @jackkucinski.bsky.social · Jul 23
Additionally, we developed a PerCell ChIP-seq approach for spike-in chromatin normalization and quantitative analysis with our collaborators in the Stanton Lab in @cp-cellrepmethods.bsky.social. www.cell.com/cell-reports...
Highly quantitative measurement of differential protein-genome binding with PerCell chromatin sequencing
Tallan et al. report a versatile approach for highly quantitative protein-genome binding, demonstrating applications for human and zebrafish cells. The proposed PerCell methodology and analysis strate...
www.cell.com
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jackkucinski.bsky.social
Jack Kucinski @jackkucinski.bsky.social · Jul 23
I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo
Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1 oncoprotein function...
www.cell.com
2 2 16