Lightnews — Scholar-powered news

Jacob Kimmel @jacobkimmel.bsky.social · May 6

we're entering a new phase @newlimitbio.bsky.social & beginning to progress our first medicines for aging & disease.

now more than ever, we're confident that reprogramming biology will unlock more healthy years in each life.

it's a privilege to build this future with generational partners.

NewLimit @newlimitbio.bsky.social · May 6

NewLimit has raised a $130M Series B led by Kleiner Perkins alongside NFDG, @khoslaventures.bsky.social, Human Capital and returning investors Dimension & Founders Fund

We're grateful for their boldness in joining us on our journey to extend human healthspan

blog.newlimit.com/p/newlimit-r...

NewLimit raises $130 million Series B led by Kleiner Perkins alongside NFDG, Khosla Ventures, Human Capital and others

NewLimit is developing medicines to extend human healthspan through epigenetic reprogramming

blog.newlimit.com

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Jacob Kimmel @jacobkimmel.bsky.social · May 4

health is both the most valuable commodity & a Jevons good.

the more healthy years/$ you can buy, the more total health spending will *increase*. there's no upper bound on value for therapeutic & enhancement products that really work.

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Jacob Kimmel @jacobkimmel.bsky.social · Apr 10

close to heaven, could only be better with tartine bread

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Jacob Kimmel @jacobkimmel.bsky.social · Apr 5

AI2's paper finder is one of the best improvements to my research workflow in years

highly recommended:

Introducing Ai2 Paper Finder | Ai2

Ai2 Paper Finder is an LLM-powered literature search system that mimics the iterative paper-finding process.

allenai.org

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Jacob Kimmel @jacobkimmel.bsky.social · Mar 27

Noam is a hero. It’s a shame there are no good books about him. “Man who fed the world” doesn’t do him justice.

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Jacob Kimmel @jacobkimmel.bsky.social · Mar 23

each year @newlimitbio.bsky.social, we share an update on our progress with the public

this week, we revealed the early results from our programs in metabolism & immunology. we’re starting to see the first hints of reprogramming medicines on the horizon.

watch here: m.youtube.com/watch?v=HR0-...

NewLimit Progress Update 2025

YouTube video by NewLimit

m.youtube.com

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Jacob Kimmel @jacobkimmel.bsky.social · Mar 14

early winter @newlimitbio.bsky.social:

- +3 TF sets with efficacy in animal disease models
- +3 TF sets that restore youthful function in old T cells
- 20X increase in humanized liver screening throughput
- 2X better in silico reprogramming than the best baseline

details: bit.ly/4iuBvqC

January // February 2025 Progress Update

Therapeutic beginnings

blog.newlimit.com

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Jacob Kimmel @jacobkimmel.bsky.social · Mar 1

cognitive drills are substantially underrated in molecular biology & genomics

half of creativity is having the ingredients for invention top of mind

building a Borgesian mental library of enzymes & reactions pays dividends

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Jacob Kimmel @jacobkimmel.bsky.social · Jan 14

thanks for sharing, reached out :)

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Jacob Kimmel @jacobkimmel.bsky.social · Jan 9

2024 @newlimitbio.bsky.social:

- 10X Engine throughput
- Discovered TF sets that reprogram cell age & preserve type
- Restored youthful function in a disease model with drug-like reprogramming

we demonstrated that reprogramming medicines are possible

2025: we start to develop them

bit.ly/4h7rrD3

2024 Year in Review

Restoring youthful function

bit.ly

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Reposted by Jacob Kimmel

Anshul Kundaje @anshulkundaje.bsky.social · Jan 8

Congrats to Johannes Linder, David Kelley et al. on the journal publication of Borzoi - a long context sequence models of RNA-seq coverage profiles with many nice applications for transcriptional & post-transcriptional regulation & variant effect prediction.

www.nature.com/articles/s41... 1/

Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation - Nature Genetics

Borzoi adapts the Enformer sequence-to-expression model to directly predict RNA-seq coverage, enabling the in-silico analysis of variant effects across multiple layers of gene regulation.

www.nature.com

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Jacob Kimmel @jacobkimmel.bsky.social · Jan 3

this is gorgeous! any trick to spotting these events?

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Jacob Kimmel @jacobkimmel.bsky.social · Dec 23

would love to meet while you’re in town

for hotels, South SF is probably a good 80/20. mostly oriented toward biotech travelers & ~15’ from downtown.

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Jacob Kimmel @jacobkimmel.bsky.social · Dec 9

the Sound Life Cohort from Allen Immunology has 100+ patients for PBMCs.

Unfortunately I don’t think there are any multi-tissue unified efforts at that scale yet, so the best data available today might need to integrate across studies.

Jacob Kimmel @jacobkimmel.bsky.social · Dec 5

zenodo wrapped: which supplemental methods did you most rely upon 🙂

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Jacob Kimmel @jacobkimmel.bsky.social · Nov 29

excited to dig into this, congratulations to the team 🎉

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Jacob Kimmel @jacobkimmel.bsky.social · Nov 27

obesity installs an epigenetic memory that persists even after weight loss

this memory makes animals gain weight again rapidly -- maybe part of why dieting is insufficient

imagine we'll see reprogramming medicines to restore healthy, youthful function in these cells over time

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

www.nature.com

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