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jahoffman1.bsky.social
Jacob A Hoffman
@jahoffman1.bsky.social
290 followers 230 following 4 posts
PhD - Penn - Wilson Lab - AAVxGlycobiology MIT - Novo Nordisk AI Postdoctoral Fellow - Belcher Lab
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jahoffman1.bsky.social
Jacob A Hoffman @jahoffman1.bsky.social · Dec 5
Would love to get on this!
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jahoffman1.bsky.social
Jacob A Hoffman @jahoffman1.bsky.social · Nov 26
Can I get in there too?? Thanks!
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Reposted by Jacob A Hoffman
drjonlim.bsky.social
Jon Lim, MRCP PhD @drjonlim.bsky.social · Nov 23
🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov
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jahoffman1.bsky.social
Jacob A Hoffman @jahoffman1.bsky.social · Nov 19
Ever wondered how gene therapies know where to go? Screening AAV vector libraries across different species I uncovered evidence of altered #glycan profiles between mouse, NHP and human liver, with implications for translation of #AAV #genetherapy

pubmed.ncbi.nlm.nih.gov/39001819/

Enjoy!
Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity - PubMed
Effective use of adeno-associated viruses (AAVs) for clinical gene therapy is limited by their propensity to accumulate in and transduce the liver. This natural liver tropism is associated with severe...
pubmed.ncbi.nlm.nih.gov
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jahoffman1.bsky.social
Jacob A Hoffman @jahoffman1.bsky.social · Nov 19
Hi @bsky.app #glycobiology community! Seems pretty sweet over here
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