Jake Choby
@jakechoby.bsky.social
Assistant Professor, University of North Carolina
Antibiotic heteroresistance in Enterobacterales
chobylab.org
Antibiotic heteroresistance in Enterobacterales
chobylab.org
Reposted by Jake Choby
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology
The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.
www.nature.com
October 10, 2025 at 1:24 PM
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
Reposted by Jake Choby
Super excited to share our paper online 🚨today🚨 in Cell Host & Microbe! Xiaomei Ren @xiaomeiren.bsky.social and Mason Clark @rmasonclark.bsky.social co-led discovery of ecological factors for Acinetobacter baumannii carriage in the gut, a reservoir for pathogen spread. 🎉
tinyurl.com/443kfefk
tinyurl.com/443kfefk
Amino acid competition shapes A. baumannii gut carriage
Acinetobacter baumannii uses ornithine to compete w/ microbiota & persist in gut. Amino acid supplementation & differences in diet promote A. baumannii gut colonization in mice & humans
@laurenpalmer.bsky.social
www.cell.com/cell-host-mi...
Acinetobacter baumannii uses ornithine to compete w/ microbiota & persist in gut. Amino acid supplementation & differences in diet promote A. baumannii gut colonization in mice & humans
@laurenpalmer.bsky.social
www.cell.com/cell-host-mi...
Amino acid competition shapes Acinetobacter baumannii gut carriage
Ren and Clark et al. show that Acinetobacter baumannii uses ornithine to compete with
the resident microbiota and persist in the gut. Additional evidence demonstrates that
amino acid supplementation a...
www.cell.com
August 4, 2025 at 8:26 PM
Super excited to share our paper online 🚨today🚨 in Cell Host & Microbe! Xiaomei Ren @xiaomeiren.bsky.social and Mason Clark @rmasonclark.bsky.social co-led discovery of ecological factors for Acinetobacter baumannii carriage in the gut, a reservoir for pathogen spread. 🎉
tinyurl.com/443kfefk
tinyurl.com/443kfefk
Excited to share the work with @dweisslab.bsky.social and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW
Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline
Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...
rdcu.be
July 2, 2025 at 2:43 PM
Excited to share the work with @dweisslab.bsky.social and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW
Reposted by Jake Choby
So much joy to see everyone today coming together to celebrate 20 years of the Skaar Lab. Thank you to Eric for the leadership and mentorship over the years! 🥰
April 5, 2025 at 11:00 PM
So much joy to see everyone today coming together to celebrate 20 years of the Skaar Lab. Thank you to Eric for the leadership and mentorship over the years! 🥰
Reposted by Jake Choby
News & Views 📄 - Zinc-dependent β-lactam resistance at a cost
By Jacob Choby & David Weiss
www.nature.com/articles/s41...
By Jacob Choby & David Weiss
www.nature.com/articles/s41...
Zinc-dependent β-lactam resistance at a cost - Nature Microbiology
Chemical genomics reveals the fitness cost of bacterial metallo-β-lactamase in zinc-deplete environments, with implications for treatment options.
www.nature.com
January 6, 2025 at 10:50 PM
News & Views 📄 - Zinc-dependent β-lactam resistance at a cost
By Jacob Choby & David Weiss
www.nature.com/articles/s41...
By Jacob Choby & David Weiss
www.nature.com/articles/s41...
pleased to share our (with @dweisslab.bsky.social) News & Views perspective on this exciting paper
nam11.safelinks.protection.outlook.com?url=https%3A...
nam11.safelinks.protection.outlook.com?url=https%3A...
January 6, 2025 at 5:20 PM
pleased to share our (with @dweisslab.bsky.social) News & Views perspective on this exciting paper
nam11.safelinks.protection.outlook.com?url=https%3A...
nam11.safelinks.protection.outlook.com?url=https%3A...