Jason Zhang 🏳️🌈🇺🇸
@jasonzxzhang.bsky.social
Computational designer of molecular tools for intracellular signaling. Assistant Professor at UCLA Bioengineering. https://scholar.google.com/citations?user=T_SIIAsAAAAJ&hl=en
Pinned
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.
Reposted by Jason Zhang 🏳️🌈🇺🇸
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
October 31, 2025 at 1:18 PM
Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.
First lab meeting at UCLA joint with @yamadahunter.bsky.social lab!
November 22, 2025 at 10:00 PM
First lab meeting at UCLA joint with @yamadahunter.bsky.social lab!
Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
September 30, 2025 at 11:42 PM
Excited to share our latest work in expanding AI-based protein design into targeting PTMs! I’m particularly excited in this work as there is so much we don’t know about PTMs despite their central role in signaling and hopefully we can start to decode their rules and functions.
Incoming from David Baker lab! New faculty at @riceuniversity.bsky.social and @uclaengineering.bsky.social with @linnaan.bsky.social and I, respectively. Last meal before we get “real world” jobs 😭.
September 1, 2025 at 1:06 AM
Incoming from David Baker lab! New faculty at @riceuniversity.bsky.social and @uclaengineering.bsky.social with @linnaan.bsky.social and I, respectively. Last meal before we get “real world” jobs 😭.
Reposted by Jason Zhang 🏳️🌈🇺🇸
Trump freezes $200 million in UCLA science and medical research funding, citing antisemitism
Trump freezes $200 million in UCLA science and medical research funding, citing antisemitism
The Trump administration has frozen roughly $200 million in National Science Foundation, National Institutes of Health and other federal agency-funded research at UCLA, citing allegations the school discriminates in admissions and has failed to protect the civil rights of Jewish students.
www.latimes.com
August 1, 2025 at 4:26 AM
Trump freezes $200 million in UCLA science and medical research funding, citing antisemitism
Excited to share that I’ll be joining UCLA Bioengineering as a tenure-track professor! My lab will focus on AI-driven molecular engineering to study cellular signaling. As someone 100% educated in US public schools, I’m proud to continue working in public education and inspiring future scientists!
July 16, 2025 at 6:22 PM
Excited to share that I’ll be joining UCLA Bioengineering as a tenure-track professor! My lab will focus on AI-driven molecular engineering to study cellular signaling. As someone 100% educated in US public schools, I’m proud to continue working in public education and inspiring future scientists!
I’ve been trying to find some reliable news about this. Are there funding cuts to NIH and NSF proposed in the Big Beautiful (really Ugly) Bill? If so, how much are the cuts?
July 3, 2025 at 7:45 AM
I’ve been trying to find some reliable news about this. Are there funding cuts to NIH and NSF proposed in the Big Beautiful (really Ugly) Bill? If so, how much are the cuts?
Was so nice to meet up with @grocklin.bsky.social and talk about science! So much to learn from him. Hopefully we can be neighbors soon!
April 28, 2025 at 6:16 AM
Was so nice to meet up with @grocklin.bsky.social and talk about science! So much to learn from him. Hopefully we can be neighbors soon!
Excited to share my recent work on designing new Hsp70 activators to regulate condensates, and thus reveal their functions: www.sciencedirect.com/science/arti... @uwproteindesign.bsky.social @cp-cellchembiol.bsky.social
De novo designed Hsp70 activator dissolves intracellular condensates
Protein quality control (PQC) is carried out in part by the chaperone Hsp70 in concert with adapters of the J-domain protein (JDP) family. The JDPs, a…
www.sciencedirect.com
February 7, 2025 at 9:56 PM
Excited to share my recent work on designing new Hsp70 activators to regulate condensates, and thus reveal their functions: www.sciencedirect.com/science/arti... @uwproteindesign.bsky.social @cp-cellchembiol.bsky.social
Very cool work from my undergrad buddy! If you are interested in virology, high throughput techniques, and biochemistry, please take a read!
Thank you to @jbloomlab.bsky.social for the opportunity to work on/lead this study. We employ a pseudovirus system that is non-replicative and a safe way to study mutations to rabies G. Jesse already authored a very nice overarching summary, so I’ll zoom in on a couple points.
In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
December 22, 2024 at 5:33 AM
Very cool work from my undergrad buddy! If you are interested in virology, high throughput techniques, and biochemistry, please take a read!
I made a protein designer starter pack ⚛️👨💻👩💻! Please feel free to DM me if you want to be added. go.bsky.app/JcMhjLw
November 20, 2024 at 2:11 AM
I made a protein designer starter pack ⚛️👨💻👩💻! Please feel free to DM me if you want to be added. go.bsky.app/JcMhjLw
My favorite probe is the one I made: Ras activity sensors! www.nature.com/articles/s41...
November 17, 2024 at 1:22 PM
My favorite probe is the one I made: Ras activity sensors! www.nature.com/articles/s41...
We love signaling!
I made a starter pack for people interested in signal transduction! Please include yourself or others!
Tagging a few people to spread the word: @drstarbird.bsky.social @fantauzzolab.bsky.social @alextoker.bsky.social
go.bsky.app/MVvjypg
Tagging a few people to spread the word: @drstarbird.bsky.social @fantauzzolab.bsky.social @alextoker.bsky.social
go.bsky.app/MVvjypg
November 17, 2024 at 1:20 PM
We love signaling!
Just started my BlueSky account! Wondering how this will go 🤔. Will still post on my Twitter (@jasonzxzhang) as well for the time being.
November 12, 2024 at 9:41 PM
Just started my BlueSky account! Wondering how this will go 🤔. Will still post on my Twitter (@jasonzxzhang) as well for the time being.