Journal of Clinical Epidemiology
@jclinepi.bsky.social
Metascience and innovative methods to improve population health
Co-Editors-in-Chief: @andreatricco.bsky.social and @davidit.bsky.social
Jclinepi.com
Published by Elsevier
Co-Editors-in-Chief: @andreatricco.bsky.social and @davidit.bsky.social
Jclinepi.com
Published by Elsevier
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To connect our BlueSky community & promote the work of our authors, we started an #JClinEpi Authors Starter Pack.
If you've published with us and would like to be included, please reply with a short description of the paper and a link.
Reposted by Journal of Clinical Epidemiology
#CochraneDaily Just published! Scoping review of 165 studies maps factors associated with citation rates and reasons for and extent of citation bias in the health literature
www.jclinepi.com/article/S089...
#Bias #Citation
@jclinepi.bsky.social
www.jclinepi.com/article/S089...
#Bias #Citation
@jclinepi.bsky.social
www.jclinepi.com
November 26, 2025 at 9:21 AM
#CochraneDaily Just published! Scoping review of 165 studies maps factors associated with citation rates and reasons for and extent of citation bias in the health literature
www.jclinepi.com/article/S089...
#Bias #Citation
@jclinepi.bsky.social
www.jclinepi.com/article/S089...
#Bias #Citation
@jclinepi.bsky.social
Reposted by Journal of Clinical Epidemiology
This infographic captures the full process in a single view.
November 22, 2025 at 4:27 PM
This infographic captures the full process in a single view.
Reposted by Journal of Clinical Epidemiology
The new GRADE Guidance on using RCTs and NRSIs in evidence synthesis is out in JCE. Years of diagrams and domain debates distilled into a practical roadmap. If you work in guidelines or HTA, this one’s for you.
#GRADE #EvidenceSynthesis #SystematicReview #HTA
www.jclinepi.com/article/S089...
#GRADE #EvidenceSynthesis #SystematicReview #HTA
www.jclinepi.com/article/S089...
GRADE guidance 44: Strategies to enhance the utilization of randomized and non-randomized studies in evidence syntheses of health interventions
Ideally, guideline developers and HTA authors base intervention decisions on randomized
controlled trials (RCTs). However, relying solely on RCTs is uncommon, especially
for public health intervention...
www.jclinepi.com
November 22, 2025 at 4:27 PM
The new GRADE Guidance on using RCTs and NRSIs in evidence synthesis is out in JCE. Years of diagrams and domain debates distilled into a practical roadmap. If you work in guidelines or HTA, this one’s for you.
#GRADE #EvidenceSynthesis #SystematicReview #HTA
www.jclinepi.com/article/S089...
#GRADE #EvidenceSynthesis #SystematicReview #HTA
www.jclinepi.com/article/S089...
Reposted by Journal of Clinical Epidemiology
Excellent and highly readable explanation of ESTIMANDS, and how thinking carefully about them clarifies planning, and interpretation of results from, any clinical trial.
www.jclinepi.com/article/S089...
And full text is freely available.
www.jclinepi.com/article/S089...
And full text is freely available.
November 17, 2025 at 8:05 PM
Excellent and highly readable explanation of ESTIMANDS, and how thinking carefully about them clarifies planning, and interpretation of results from, any clinical trial.
www.jclinepi.com/article/S089...
And full text is freely available.
www.jclinepi.com/article/S089...
And full text is freely available.
Dysinclusion: Naming and defining the inequitable absence of marginalized populations in health research - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Dysinclusion: Naming and defining the inequitable absence of marginalized populations in health research
Marginalized populations are frequently absent or invisible in health research. Yet
this problem is seldom characterized as a distinct methodological concern. Existing
concepts like selection bias or ...
www.jclinepi.com
November 17, 2025 at 7:21 PM
Dysinclusion: Naming and defining the inequitable absence of marginalized populations in health research - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Scalable Medication Extraction and Discontinuation Identification from Electronic Health Records Using Large Language Models - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Scalable Medication Extraction and Discontinuation Identification from Electronic Health Records Using Large Language Models
Identifying medication discontinuations in electronic health records (EHRs) is vital
for patient safety but is often hindered by information being buried in unstructured
notes. This study aims to eval...
www.jclinepi.com
November 17, 2025 at 7:21 PM
Scalable Medication Extraction and Discontinuation Identification from Electronic Health Records Using Large Language Models - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Identifying ethical issues in stepped-wedge cluster randomized trials to inform the Ottawa Statement update: a systematic review of trials published 2016-2022 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Identifying ethical issues in stepped-wedge cluster randomized trials to inform the Ottawa Statement update: a systematic review of trials published 2016-2022
The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials,
published in 2012, is the first and remains the only international ethics guidance
document specific to cluster ran...
www.jclinepi.com
November 17, 2025 at 7:20 PM
Identifying ethical issues in stepped-wedge cluster randomized trials to inform the Ottawa Statement update: a systematic review of trials published 2016-2022 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Key concepts series: Estimands: what they are and why we should use them - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Estimands: what they are and why we should use them
In clinical trials, post-randomisation events, such as treatment discontinuation or
the use of rescue medication, can complicate the interpretation of results. An estimand
is a precise description of ...
www.jclinepi.com
November 17, 2025 at 7:20 PM
Key concepts series: Estimands: what they are and why we should use them - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Developing a framework for assessing the applicability of the target condition in diagnostic research - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Developing a framework for assessing the applicability of the target condition in diagnostic research
Assessment of the applicability of primary studies is an essential but often challenging
aspect of systematic reviews of diagnostic test accuracy studies (DTA reviews). We
explored review authors’ app...
www.jclinepi.com
November 17, 2025 at 7:17 PM
Developing a framework for assessing the applicability of the target condition in diagnostic research - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 8: Considering equity - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 8: Considering equity
To ensure practice guidelines contribute to improving equity, guideline developers
need to consciously consider populations experiencing inequities throughout the process.
Our aim was to describe whet...
www.jclinepi.com
November 17, 2025 at 7:16 PM
Guideline Organizations’ Guidance Documents Paper 8: Considering equity - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 11: Quality Assurance and Improvement in Guideline Development - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 11: Quality Assurance and Improvement in Guideline Development
The integration of quality assurance and improvement (QAI) into all steps of guideline
development can promote the measurability and relevance of guidelines to real-world
practice. Our objective was t...
www.jclinepi.com
November 17, 2025 at 7:13 PM
Guideline Organizations’ Guidance Documents Paper 11: Quality Assurance and Improvement in Guideline Development - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Potential Waste in Evidence Synthesis for Health Screening: A Scoping Review and Call for Action - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Potential Waste in Evidence Synthesis for Health Screening: A Scoping Review and Call for Action
To estimate the extent of potential research waste in the production of evidence synthesis
products for health screening, providing an initial assessment of its magnitude.
www.jclinepi.com
November 17, 2025 at 7:13 PM
Potential Waste in Evidence Synthesis for Health Screening: A Scoping Review and Call for Action - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Key concepts: FAIRification of biomedical research data - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
FAIRification of biomedical research data
The Findable, Accessible, Interoperable, and Reusable guiding principles promote Findability,
Accessibility, Interoperability, and Reuse of data to enhance data management and
stewardship. In biomedic...
www.jclinepi.com
November 17, 2025 at 7:12 PM
Key concepts: FAIRification of biomedical research data - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Key Concepts series: Overview of evidence synthesis types and modes - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Overview of evidence synthesis types and modes
Evidence syntheses systematically compile and analyze information from multiple sources
to support health-care decision-making. As many different types of questions need
to be answered in health care,...
www.jclinepi.com
November 17, 2025 at 7:11 PM
Key Concepts series: Overview of evidence synthesis types and modes - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Editors’ choice - November 2025: Methods for Living Guidelines Series - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Editors’ choice - November 2025: Methods for Living Guidelines Series
Observing the unprecedented political attack on science currently occurring in the
United States is painful for us to watch as Editors of a scientific journal. It is
no surprise that this was top of m...
www.jclinepi.com
November 17, 2025 at 7:10 PM
Editors’ choice - November 2025: Methods for Living Guidelines Series - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
The @jclinepi.bsky.social November issue is online! www.jclinepi.com/current
November 17, 2025 at 7:08 PM
The @jclinepi.bsky.social November issue is online! www.jclinepi.com/current
Toward transparent and accountable artificial intelligence in systematic review appraisal - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Toward transparent and accountable artificial intelligence in systematic review appraisal
We commend Marques-Cruz et al for their careful evaluation of large language models
(LLMs) in assessing the methodological quality of systematic reviews using the Reported
Methodological Quality (ReMa...
www.jclinepi.com
November 10, 2025 at 3:53 PM
Toward transparent and accountable artificial intelligence in systematic review appraisal - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care
To undertake a formal process to identify and prioritise clinical topics for the updating
of the Australian Pregnancy Care Guidelines and development of new Australian Postnatal
Care Guidelines for th...
www.jclinepi.com
November 10, 2025 at 3:53 PM
So where do we start? Prioritising clinical topics for the new Australian living guidelines for pregnancy and postnatal care - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Framing Evidence Synthesis production with the lens of Sustainable Knowledge - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Framing Evidence Synthesis production with the lens of Sustainable Knowledge
Systematic reviews are widely recognized as the cornerstone of evidence-based health
decision-making. Individual studies are synthesized into coherent summaries, providing
clarity amid the complexity ...
www.jclinepi.com
November 10, 2025 at 3:52 PM
Framing Evidence Synthesis production with the lens of Sustainable Knowledge - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Most methodological characteristics do not exaggerate effect estimates in nutrition RCTs: findings from a meta-epidemiological study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Most methodological characteristics do not exaggerate effect estimates in nutrition RCTs: findings from a meta-epidemiological study
To evaluate the influence of bias from methodological characteristics on intervention
effect estimates in nutrition randomised controlled trials (RCTs) using the Cochrane
RoB2 tool.
www.jclinepi.com
November 10, 2025 at 3:51 PM
Most methodological characteristics do not exaggerate effect estimates in nutrition RCTs: findings from a meta-epidemiological study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Preference-based controlled design: toward increased patients’ engagement, efficiency and external validity of cardiovascular clinical trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Preference-based controlled design: toward increased patients’ engagement, efficiency and external validity of cardiovascular clinical trials
Randomized controlled trials (RCTs) are the gold standard for evaluating clinical
interventions, but their limitations—particularly in settings where strong patient
preferences exist—can impair recrui...
www.jclinepi.com
November 10, 2025 at 3:50 PM
Preference-based controlled design: toward increased patients’ engagement, efficiency and external validity of cardiovascular clinical trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Methodological review reveals essential gaps and inconsistencies in clinical claims, effects and outcomes in HTA reviews of diagnostic tests - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Methodological review reveals essential gaps and inconsistencies in clinical claims, effects and outcomes in HTA reviews of diagnostic tests
Essential first steps in performing a health technology assessment (HTA) for a diagnostic
test include: consideration of the clinical pathway in which the test will be used,
specifying the clinical cl...
www.jclinepi.com
November 10, 2025 at 3:50 PM
Methodological review reveals essential gaps and inconsistencies in clinical claims, effects and outcomes in HTA reviews of diagnostic tests - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
A qualitative study among guideline developers revealed challenges and strategies for rare disease guideline development - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
A qualitative study among guideline developers revealed challenges and strategies for rare disease guideline development
Clinical practice guideline (CPG) development for rare diseases is challenging due
to scarce evidence, small expert groups, limited resources, and heterogeneity and
complexity of conditions. Critical ...
www.jclinepi.com
November 10, 2025 at 3:45 PM
A qualitative study among guideline developers revealed challenges and strategies for rare disease guideline development - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Core GRADE unpacked: A summary of recent innovations in complementary GRADE Methodology - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Core GRADE unpacked: A summary of recent innovations in complementary GRADE Methodology
The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework
has become the global standard for rating evidence certainty and grading strength
of healthcare recommendations ...
www.jclinepi.com
November 10, 2025 at 3:44 PM
Core GRADE unpacked: A summary of recent innovations in complementary GRADE Methodology - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Editors' choice: The challenges and opportunities of artificial intelligence and their impact on the journal - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
The challenges and opportunities of artificial intelligence and their impact on the journal
As the keepers of the editorial “front door” of the journal, we are profoundly aware
of the myriad challenges and some opportunities that accompany the ubiquitous rise
of artificial intelligence (AI) ...
www.jclinepi.com
November 10, 2025 at 3:43 PM
Editors' choice: The challenges and opportunities of artificial intelligence and their impact on the journal - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...