As @neurome.bsky.social and Yu point out, #methodsmatter. They are spot on here: www.nature.com/articles/s41...

Harry Pritchard and I are currently offering a PhD combining a data-science with a physiological approach to find therapeutic targets for dementia and hypertension.
We're looking for someone interested in both physiology and data-science techniques.
www.findaphd.com/phds/project...

That was lovely. I learnt so much. Really recommend the Tuesday late opening, as I had all the time in the world to read the captions. (I only regretted being alone when I had to cross through all the taxidermy without someone else to watch them for signs of movement.)

I am having the absolute BEST time at the Manchester Museum. Here’s a wonderful fact one of the volunteers told me: you know that we used to bury the dead with meat for the journey to the next life in this country, too?

Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/

www.encodeproject.org/single-cell/...

The first preprint of 2025! Together with Matvei, @halfacrocodile.bsky.social, & our amazing team, we are excited to share PARADE: an AI framework for designing mRNA UTRs with enhanced cell-type specificity & stability. www.biorxiv.org/content/10.1...

I would seriously question the assertion that GWAS and burden tests are conceptually similar. I think it’s expected that they point toward two separate sets of genes.

Exactly. What I expect from a labour government is that they actually try and improve the cs by doing the hard work that the tories are incapable of (for political reasons).

I cannot put into words how much I enjoyed this post.

Tango strikes again

Totally, very intelligent strategy

“Pausable”? is that spelling mistake deliberate. We “pause” our reading?

I've written about what dying typically looks like - not as a 'pro' or 'anti' AD piece, but in the spirit of confronting a taboo.

We've lost the easy familiarity with the patterns of dying that existed when death typically occurred in people’s own homes.

Let's talk about it 🙏

@newstatesman.com

Much more detail here

www.dementiaresearcher.nihr.ac.uk/job/phd-usin...

Our preprint:

Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart

Multiomic atlas + human genetics = new cell types, genes, and pathways that influence heart development and disease

www.medrxiv.org/content/10.1...

Thread 👇

We're advertising a PhD on the multi-omics of dementia and hypertension at @official-uom.bsky.social supervised by me, @harry-pritchard.bsky.social, Prof Wardlaw and Dr Chappell from Edinburgh University www.findaphd.com/phds/project...

Very impressive work. Nuanced and thoughtful throughout. The schematic summary (in extended data) and plain English FAQ (in supp note 1) should be commended.

This is very interesting and highly relevant paper to clinical genetics and rare disease researchers. I wrote the accompanying News & Views piece. Free sharing link here: rdcu.be/d0VlK