Jingchuan Luo
@jingchuanluo.bsky.social
Pinned
Jingchuan Luo
@jingchuanluo.bsky.social
· Aug 27
I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.
Thank you for developing LOV-BirA! Without it, this work wouldn't have been possible. It was wonderful to work together.
Proximity-specific ribosome profiling using LOV-BirA reveals two distinct strategies for mitochondrially-localized translation: one for long coding sequences and one for short. It was a pleasure to contribute to this beautiful work from Jonathan Weissman @weissmanlab.bsky.social and Jingchuan Luo
August 27, 2025 at 9:47 PM
Thank you for developing LOV-BirA! Without it, this work wouldn't have been possible. It was wonderful to work together.
Reposted by Jingchuan Luo
LOCL-TL allows researchers to study which proteins are being made, or translated, at specific locations within the cell. @jswlab.bsky.social developed this tool and used it to characterize translation happening at the mitochondria. wi.mit.edu/news/locally... @hhmi.org
Locally produced proteins help mitochondria function | Whitehead Institute
Jonathan Weissman and colleagues developed an optogenetic approach to study where in the cell proteins get made and used it to characterize two groups of proteins produced next to mitochondria. This c...
wi.mit.edu
August 27, 2025 at 3:49 PM
LOCL-TL allows researchers to study which proteins are being made, or translated, at specific locations within the cell. @jswlab.bsky.social developed this tool and used it to characterize translation happening at the mitochondria. wi.mit.edu/news/locally... @hhmi.org
I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.
August 27, 2025 at 9:44 PM
I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.