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Ioannis Skalidis

@johnskal.bsky.social

130 followers 360 following 11 posts

MSCA post-doctoral researcher at Förster lab, Utrecht university. SPA guy trying to navigate Tomo. Lover of big protein complexes and even bigger scopes. I'm new here. #structuralbiology #cryoem

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Reposted by Ioannis Skalidis

cryoEM papers @cryoempapers.bsky.social · Sep 2

Direct evidence of acid-driven protein desolvation www.biorxiv.org/content/10.1101/2025.09.01.673474v1 #cryoem

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Ioannis Skalidis @johnskal.bsky.social · Sep 2

If you wanna read a nice resume of the work, here's the LinkedIn post: www.linkedin.com/posts/pkastr...

Direct evidence of acid-driven protein desolvation | Panagiotis Kastritis

Did you know that proteins lose bound waters upon acidification? We didn't as well. But we visualized this phenomenon in a series of high-resolution cryo-EM structures (~2 Å) across different pH value...

www.linkedin.com

Ioannis Skalidis @johnskal.bsky.social · Sep 2

A project that would never leave my mind during my PhD is finally out!

We used #cryo-em #spa #md to see how the solvation layer of a protein is affected during acidification!

Really cool insights and a truly fundamental work, congrats to all involved!

www.biorxiv.org/content/10.1...

Direct evidence of acid-driven protein desolvation

Water and its ability to modulate the protonation states of biomolecules govern the physical chemistry of life, dictating their metabolic functions. However, how amino acid protonation alters protein ...

www.biorxiv.org

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Ioannis Skalidis @johnskal.bsky.social · Mar 23

The first project I worked on, right after joining @bijvoet-centre.bsky.social!

cryoEM papers @cryoempapers.bsky.social · Mar 20

Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus www.biorxiv.org/content/10.1101/2025.03.19.643997v1 #cryoem

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Ioannis Skalidis @johnskal.bsky.social · Feb 22

Damn, I'm sad I just found out about this one only now!

Frank Noe @franknoe.bsky.social · Dec 6

Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.

www.biorxiv.org/content/10.1...

Ioannis Skalidis @johnskal.bsky.social · Feb 17

Thank you very much Andrea!

Ioannis Skalidis @johnskal.bsky.social · Feb 12

I have a couple of nice visualization snippets for chimerax that I have gathered from here, there, and my own stuff. Would be cool to have somewhere to deposit them!

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Ioannis Skalidis @johnskal.bsky.social · Feb 11

Oh, forgot to tag @bijvoet-centre.bsky.social where the Structural Biochemistry group is a part of!

Ioannis Skalidis @johnskal.bsky.social · Feb 11

I guess I should have posted a bit earlier, but I'm very excited that my #MSCA application got accepted! I'll be working at @fridof.bsky.social lab @utrechtuniversity.bsky.social to develop my #teamtomo skills on my project: Protein ER-ways! Here's to gaining new insights on ER protein biogenesis!

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Ioannis Skalidis @johnskal.bsky.social · Feb 8

Is this infographic true? Did these unis charge 60%+ for overheads????

Ioannis Skalidis @johnskal.bsky.social · Jan 18

EMDB/PDB code is not even necessary, and tbh I never require it. Just send me a chimerax session with everything inside. How hard is that to do?

Ioannis Skalidis @johnskal.bsky.social · Jan 17

Having now worked myself on tomo data collection and analysis makes me appreciate the enormity of this work even more! Amazing stuff...

Beck Laboratory @becklab.bsky.social · Jan 17

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below: