jorihag.bsky.social
Joris Hageman
@jorihag.bsky.social
180 followers 110 following 5 posts
PhD student @hugosnippert.bsky.social lab organoids - stem cells - CRISPR
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jorihag.bsky.social
Joris Hageman @jorihag.bsky.social · Jul 29
Thanks to the @hugosnippert.bsky.social lab and all co-authors!
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jorihag.bsky.social
Joris Hageman @jorihag.bsky.social · Jul 29
I’m happy to share our new preprint on stem cell regeneration in the human colon! Using new CRISPR knockins in organoids, we show that after stem cell loss, non-stem cells rapidly regenerate them. This process is normally inhibited by the stem cells themselves. Manuscript link: tinyurl.com/3ky4ccxf
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Reposted by Joris Hageman
hugosnippert.bsky.social
Snippert lab @hugosnippert.bsky.social · Jul 16
📢 New preprint 🔥
1/ Stem cell regeneration is often viewed as an actively induced process, triggered by damage. But what if plasticity is actively suppressed by the stem cells themselves? We explored plasticity with 'new' cell type ablation tech in normal human colon organoids
tinyurl.com/3ky4ccxf
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jorihag.bsky.social
Joris Hageman @jorihag.bsky.social · May 24
Volgens mij gaat het al aardig mis bij het eerste artikel
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jorihag.bsky.social
Joris Hageman @jorihag.bsky.social · May 22
Heel jammer!!
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jorihag.bsky.social
Joris Hageman @jorihag.bsky.social · Dec 2
Check out this very cool new preprint by our lab on how intestinal tuft cells differentiate! 🤩 @julian-buissant.bsky.social @hugosnippert.bsky.social
hugosnippert.bsky.social
Snippert lab @hugosnippert.bsky.social · Dec 1
New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA
Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia
Intestinal tuft cells are epithelial sentinels that trigger host defense upon detection of parasite-derived compounds. While representing interesting targets for immunomodulatory therapies in inflamma...
shorturl.at
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