But popular demand: the shareable, accessible link! rdcu.be/d5z6s

We highlight the core building blocks, challenges and opportunities in integration and translation, as well as the outlook on this rapidly growing and exciting field.

w/ landmark proofs-of-concept from the lit., we show how these bricks can come together and provide a framework. Imagine spanning more modalities (optical, mechanical, etc) to tackle hybrids that can sense their local environment, actuate, support themselves, and more.

Think about ‘reading’ & ‘writing’ to your bioelectronic or cell-based component. We have a whole library of modalities to communicate between these realms; plus established functionality from each realm. In essence, we build a toolbox of biohybrid bricks, or biohybricks.

We recently highlighted the potential for biohybrid therapies in Science — www.science.org/doi/10.1126/...
while impactful, this only scratches the surface…

We argue that the union of bioelectronics and cell-based synthetic biology can bring biological specificity and long range communication (with other devices, stakeholders, etc), precision timing/control, or even added functionality to these broad application areas.

In this work we consider the synergistic role of bioelectronics, engineered cells, (and biomaterials) in assembling first-in-class biohybrid devices that could be critical for rising applications in living therapies, sensors, and biohybrid robotics for example.

Shout out to the this awesome crew of co-authors: Omid Veiseh, Tzahi Cohen-Karni, @rituraman.bsky.social, Katie Galloway, @jacobrobinson.bsky.social, and Christian Schreib

Just out in @natrevbioeng.bsky.social, check out our perspective on integrating bioelectronics with cell-based synthetic biology.
www.nature.com/articles/s44...