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jschoggins.bsky.social
John Schoggins
@jschoggins.bsky.social
660 followers 100 following 2 posts
Professor curious about how mammals 🐵🦇 🐭 fight viruses🦠Devote inordinate amounts of time to yoga, breadmaking, coffee. Views my own.
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jschoggins.bsky.social
John Schoggins @jschoggins.bsky.social · May 21
Very little here

The OG is Geiss/Sen 2001 microarray - polyIC in IFN-defective cells PMID:11487589

We did microarray of lenti-cGAS (IRF3 trigger, like dsRNA) in STAT1-KO cells 2014 PMID:24284630

Irving/Wang: RNA-Seq of polyIC in IFNAR2 KO bat cells, they saw IRF1/7 signature 2020 PMID:33147460
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jschoggins.bsky.social
John Schoggins @jschoggins.bsky.social · May 9
Out now! A fresh perspective on interferon-mediated antiviral activity -- How many ISGs does it take to inhibit a virus? Perhaps far fewer than we think.

dx.plos.org/10.1371/jour...
Old cytokine, new tricks: A refined model of interferon’s antiviral activity
Interferon is a central component of the vertebrate antiviral immune response, thought to act through induction of hundreds of interferon-stimulated genes, with some redundancy. This Perspective highl...
dx.plos.org
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