Christopher Ing
@jsci.bsky.social
Co-founder (https://www.proteinqure.com/), Toronto-based (🇨🇦), biophysicist (💻), peptide drug designer (💉), programmer (🐍), DJ (🎶), fan of felines (🐈). Are you looking for a job in drug discovery in Canada? DM me.
I'm surprised, but not surprised, that ChatGPT citations often point to sites like ResearchGate. RG sucks but they seem to genuinely be helping piece together scientific literature "behind the paywall" that's enabling LLMs to deliver more value...
January 28, 2026 at 11:55 PM
I'm surprised, but not surprised, that ChatGPT citations often point to sites like ResearchGate. RG sucks but they seem to genuinely be helping piece together scientific literature "behind the paywall" that's enabling LLMs to deliver more value...
You have to be opportunistic with new technologies—mostly as a result of institutional paranoia. My surge in AI coding assistant use is primarily a race against the enshittification timeline.
January 25, 2026 at 2:37 PM
You have to be opportunistic with new technologies—mostly as a result of institutional paranoia. My surge in AI coding assistant use is primarily a race against the enshittification timeline.
Conventional wisdom: "Don't let your pipes freeze, be careful!!"
Refreshing advice: "Almost let your pipes freeze, your tap water will be ice cold and delicious!"
Refreshing advice: "Almost let your pipes freeze, your tap water will be ice cold and delicious!"
January 22, 2026 at 11:56 PM
Conventional wisdom: "Don't let your pipes freeze, be careful!!"
Refreshing advice: "Almost let your pipes freeze, your tap water will be ice cold and delicious!"
Refreshing advice: "Almost let your pipes freeze, your tap water will be ice cold and delicious!"
As far as I can tell, the real reason why antimicrobial peptides aren't in clinical development is that models are too good. Shame it's a solved problem =(
January 19, 2026 at 11:35 PM
As far as I can tell, the real reason why antimicrobial peptides aren't in clinical development is that models are too good. Shame it's a solved problem =(
Okay, now try a protein LLM trained on only ancestral proteins to reduce modern bias (a simpler time without so many protein fitness influencers) github.com/haykgrigo3/T...
GitHub - haykgrigo3/TimeCapsuleLLM: A LLM trained only on data from certain time periods to reduce modern bias
A LLM trained only on data from certain time periods to reduce modern bias - haykgrigo3/TimeCapsuleLLM
github.com
January 12, 2026 at 4:38 PM
Okay, now try a protein LLM trained on only ancestral proteins to reduce modern bias (a simpler time without so many protein fitness influencers) github.com/haykgrigo3/T...
"Taken together, these results demonstrate that [method X] is a general-purpose model capable of aiding in all stages of designing and optimizing [Y] in real-world drug discovery campaigns." (...Well, except for ligand-receptor structure prediction)
January 9, 2026 at 3:08 PM
"Taken together, these results demonstrate that [method X] is a general-purpose model capable of aiding in all stages of designing and optimizing [Y] in real-world drug discovery campaigns." (...Well, except for ligand-receptor structure prediction)
Patsnap is really putting the "landscape" in IP landscape with this one. Looking forward to the minecraft server extension to properly explore the IP ecosystem (watch out for patent trolls...)
December 15, 2025 at 7:03 PM
Patsnap is really putting the "landscape" in IP landscape with this one. Looking forward to the minecraft server extension to properly explore the IP ecosystem (watch out for patent trolls...)
Never thought I'd get a chance to smell a supernova in my lifetime. Thankful.
December 7, 2025 at 7:44 PM
Never thought I'd get a chance to smell a supernova in my lifetime. Thankful.
Toronto property tax portal is like: you must enter this random 21-digit number! Then on another page their like, screw it, just put in your address we'll auto-populate it for you.
December 6, 2025 at 3:49 PM
Toronto property tax portal is like: you must enter this random 21-digit number! Then on another page their like, screw it, just put in your address we'll auto-populate it for you.
You'd be inclined to believe this innocent helper function from ChatGPT is not flawed/wrong ("atom_number" does not exist in biotite, and it's not safe to assume hydrogen atom names start with "H", i.e. if they were output from Rosetta).
December 4, 2025 at 2:23 AM
You'd be inclined to believe this innocent helper function from ChatGPT is not flawed/wrong ("atom_number" does not exist in biotite, and it's not safe to assume hydrogen atom names start with "H", i.e. if they were output from Rosetta).
2023: "de novo antibody design is solved" -AbSci
2024: "de novo antibody design is solved, we raised $1B on this" -Xaira
2025: "de novo antibody design is solved, the last time was jokes" -Chai, Nabla
20XX: "de novo antibody design is solved, can anyone hear me... anyone out there?" -Startup X
2024: "de novo antibody design is solved, we raised $1B on this" -Xaira
2025: "de novo antibody design is solved, the last time was jokes" -Chai, Nabla
20XX: "de novo antibody design is solved, can anyone hear me... anyone out there?" -Startup X
November 19, 2025 at 8:56 PM
2023: "de novo antibody design is solved" -AbSci
2024: "de novo antibody design is solved, we raised $1B on this" -Xaira
2025: "de novo antibody design is solved, the last time was jokes" -Chai, Nabla
20XX: "de novo antibody design is solved, can anyone hear me... anyone out there?" -Startup X
2024: "de novo antibody design is solved, we raised $1B on this" -Xaira
2025: "de novo antibody design is solved, the last time was jokes" -Chai, Nabla
20XX: "de novo antibody design is solved, can anyone hear me... anyone out there?" -Startup X
Trick-or-treaters weren't the only ones wearing a mask this Halloween, doi.org/10.1093/nar/...
Improved targeted delivery of antisense oligonucleotide with an antibody mask
Abstract. Antisense oligonucleotides (ASOs) are synthetic nucleic acid strands designed to modulate gene expression by binding to RNA transcripts. In brain
doi.org
November 3, 2025 at 1:32 PM
Trick-or-treaters weren't the only ones wearing a mask this Halloween, doi.org/10.1093/nar/...
Critics: "Boo, -latest/greatest AI drug discovery method- only works if you have a similar training example!"
Biotech Industry: "Hurry, let's find the smallest possible modification to this approved ligand which hits the identical target and epitope"
Biotech Industry: "Hurry, let's find the smallest possible modification to this approved ligand which hits the identical target and epitope"
October 29, 2025 at 3:34 PM
Critics: "Boo, -latest/greatest AI drug discovery method- only works if you have a similar training example!"
Biotech Industry: "Hurry, let's find the smallest possible modification to this approved ligand which hits the identical target and epitope"
Biotech Industry: "Hurry, let's find the smallest possible modification to this approved ligand which hits the identical target and epitope"
Real data tracking my head nodding at the Autechre tour stop in Toronto last night
October 23, 2025 at 2:22 PM
Real data tracking my head nodding at the Autechre tour stop in Toronto last night
“What fascinated me was the fact that you could potentially predict which molecule could have this effect using thermodynamic principles in silica” www.fiercebiotech.com/special-repo...
September 22, 2025 at 1:39 PM
“What fascinated me was the fact that you could potentially predict which molecule could have this effect using thermodynamic principles in silica” www.fiercebiotech.com/special-repo...
"We discovered a TfR1-targeted brain shuttle, check out the brain uptake" (Crook et al. 2020, doi.org/10.1016/j.jm...). "This radioligand does not efficiently cross the blood-brain barrier" (Lin et al. 2025, doi.org/10.1007/s002...)
August 12, 2025 at 1:30 PM
"We discovered a TfR1-targeted brain shuttle, check out the brain uptake" (Crook et al. 2020, doi.org/10.1016/j.jm...). "This radioligand does not efficiently cross the blood-brain barrier" (Lin et al. 2025, doi.org/10.1007/s002...)
When will a generative model pass the "Internet Turing Test"? That is, a test subject cannot distinguish an AI-generated internet from the real internet.
August 8, 2025 at 1:30 PM
When will a generative model pass the "Internet Turing Test"? That is, a test subject cannot distinguish an AI-generated internet from the real internet.
Scientists: answering the questions we were dying to know, but too afraid to ask
The physical consequences of sperm gigantism https://www.biorxiv.org/content/10.1101/2025.07.19.665658v1
July 24, 2025 at 12:53 PM
Scientists: answering the questions we were dying to know, but too afraid to ask
There's a form of "Personal Computer" Stockholm syndrome where an accumulation of weird tech issues makes computer use border on torture, with a surprising user tolerance threshold. Usually it's only identified by a 3rd party using your machine and remarking... "How the heck do you use this thing?"
July 16, 2025 at 7:15 PM
There's a form of "Personal Computer" Stockholm syndrome where an accumulation of weird tech issues makes computer use border on torture, with a surprising user tolerance threshold. Usually it's only identified by a 3rd party using your machine and remarking... "How the heck do you use this thing?"
"The Illiad" is kinda like "Three-Body Problem" in that their both about vengeful omnipresent beings fucking around with physics on earth.
July 10, 2025 at 10:06 PM
"The Illiad" is kinda like "Three-Body Problem" in that their both about vengeful omnipresent beings fucking around with physics on earth.
Sequence logo's are so underutilized, even in protein design papers. Mainly because all the libraries to create them have zero imagination for applications. Represent ensembles of any residue-level property with symbol/color, or use pos/neg enrichment to show differential bias between any two sets!
July 10, 2025 at 6:59 PM
Sequence logo's are so underutilized, even in protein design papers. Mainly because all the libraries to create them have zero imagination for applications. Represent ensembles of any residue-level property with symbol/color, or use pos/neg enrichment to show differential bias between any two sets!
Grant me the confidence of a scientist asking for help installing software in the Boltz2 webinar Zoom chat
June 18, 2025 at 12:23 PM
Grant me the confidence of a scientist asking for help installing software in the Boltz2 webinar Zoom chat
Increasingly convinced there's collusion in "big spinach" to sell washed leaves "wet" in grocery store tubs to accelerate rot and increase sales 🤫🥬💧🤑
June 7, 2025 at 5:04 PM
Increasingly convinced there's collusion in "big spinach" to sell washed leaves "wet" in grocery store tubs to accelerate rot and increase sales 🤫🥬💧🤑
leetspeak still alive in the bioinformatics community, academic.oup.com/nar/advance-...
M1CR0B1AL1Z3R 2.0: an enhanced web server for comparative analysis of bacterial genomes at scale
academic.oup.com
May 14, 2025 at 12:58 PM
leetspeak still alive in the bioinformatics community, academic.oup.com/nar/advance-...
Kinda like mining bitcoin
ALICE detects the conversion of lead into gold at the LHC
Near-miss collisions between high-energy lead nuclei at the #LHC generate intense electromagnetic fields that can knock out protons and transform lead into fleeting quantities of gold nuclei
Find out more: home.cern/news/news/ph...
Near-miss collisions between high-energy lead nuclei at the #LHC generate intense electromagnetic fields that can knock out protons and transform lead into fleeting quantities of gold nuclei
Find out more: home.cern/news/news/ph...
May 8, 2025 at 10:57 PM
Kinda like mining bitcoin