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Masaru Kanekiyo

@kanekiyom.bsky.social

900 followers 190 following 5 posts

All views/posts are my own; vaccines for life; proteins are beautiful; vaccine design; viral immunity; host-vaccine interface; vaccine immunologist; cat dad ORCiD: 0000-0001-5767-1532

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Masaru Kanekiyo @kanekiyom.bsky.social · 1d

That’s brilliant. Congrats Jason! Richly deserved.

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Masaru Kanekiyo @kanekiyom.bsky.social · May 7

Nice pictures of you two. Not to scale tho.

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Reposted by Masaru Kanekiyo

bioRxiv Immunology @biorxiv-immuno.bsky.social · Feb 27

Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques https://www.biorxiv.org/content/10.1101/2025.02.21.639368v1

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Reposted by Masaru Kanekiyo

Seth Thomas Scanlon @immunoeditor.bsky.social · Feb 6

Also last week in @science.org : @kanekiyom.bsky.social, Douglas Reed, Simon Barratt-Boyes, & colleagues show pre-exposure broadly neutralizing #antibody ( #bnAb ) #prophylaxis against a conserved supersite on #influenza #hemagglutinin (HA) stem protects #macaques against #H5N1 infection! #BirdFlu

Pre-exposure antibody prophylaxis protects macaques from severe influenza

Influenza virus pandemics and seasonal epidemics have claimed countless lives. Recurrent zoonotic spillovers of influenza viruses with pandemic potential underscore the need for effective countermeasu...

www.science.org

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Reposted by Masaru Kanekiyo

bioRxiv Immunology @biorxiv-immuno.bsky.social · Dec 3

Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1

Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed mill

www.biorxiv.org

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Masaru Kanekiyo @kanekiyom.bsky.social · Nov 23

📢Hot off the press! Our latest work studying #influenza broadly neutralizing antibody development in humanized mice. Huge thanks to everyone involved in the study🙏 #NIAID #VRC #Ragon #Scripps www.cell.com/cell-reports...

Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem

Ataca et al. describe a pathway to generate cross-reactive B cells against influenza hemagglutinin by engaging a subdominant immunoglobulin germline-encoded motif through prime-boost vaccination in IG...

www.cell.com

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Masaru Kanekiyo @kanekiyom.bsky.social · Mar 1

Here’s a link for NIAID media release covering our paper. go.nih.gov/2Lb9nnn

New Antibodies Target “Dark Side” of Influenza Virus Protein

Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored “dark side” of the neura...

go.nih.gov

Masaru Kanekiyo @kanekiyom.bsky.social · Mar 1

Hot off the press! Our latest paper on #influenza neuraminidase (NA) antibodies has just been published in Immunity. Lederhofer et al. Isolated and characterized human antibodies to the NA ‘dark side’ that are broadly cross-reactive and protective. www.cell.com/immunity/ful...

Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase

Influenza neuraminidase (NA) is underappreciated as a vaccine target owing to its incomplete epitope landscape. Lederhofer et al. isolated human monoclonal antibodies to NA underside (i.e., dark side)...

www.cell.com

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