Katherine Thomasset
@kaththomasset.bsky.social
she/her
Medical copy-editor at @diabetologiajnl.bsky.social, based at University of Bristol
All views are my own
Medical copy-editor at @diabetologiajnl.bsky.social, based at University of Bristol
All views are my own
Reposted by Katherine Thomasset
🚀 Meet @metabologiajnl.bsky.social's #EditorInChief @jenniferlsargent.bsky.social in a new #ExpertInsights ep. She shares how our new journal will bridge #diabetes & #metabolism science, connecting basic, clinical & public health #research🌍
📺Watch now & submit 👉 link.springer.com/journal/4435....
📺Watch now & submit 👉 link.springer.com/journal/4435....
December 3, 2025 at 1:35 PM
🚀 Meet @metabologiajnl.bsky.social's #EditorInChief @jenniferlsargent.bsky.social in a new #ExpertInsights ep. She shares how our new journal will bridge #diabetes & #metabolism science, connecting basic, clinical & public health #research🌍
📺Watch now & submit 👉 link.springer.com/journal/4435....
📺Watch now & submit 👉 link.springer.com/journal/4435....
Data from a Chinese cohort showing that consistently low or decreased arterial stiffness associated w/ lower risk of #CKD, highlighting the potential relevance of maintaining #cardiovascular health for #kidney outcomes #DiabetesResearch #KidneyDisease #T2D
Study showing that consistently low or decreased arterial stiffness was associated w/ lower risk of chronic kidney disease, highlighting the potential relevance of maintaining cardiovascular health for kidney outcomes #DiabetesResearch #KidneyDisease #T2D link.springer.com/article/10.1...
Time-dependent association between progression of arterial stiffness and risk of incident chronic kidney disease: a cohort study in China - Diabetologia
Aims/hypothesis The relationship between the progression of arterial stiffness and the risk of chronic kidney disease (CKD) remains unclear. This study aimed to evaluate the time-dependent association...
link.springer.com
December 4, 2025 at 7:49 AM
Data from a Chinese cohort showing that consistently low or decreased arterial stiffness associated w/ lower risk of #CKD, highlighting the potential relevance of maintaining #cardiovascular health for #kidney outcomes #DiabetesResearch #KidneyDisease #T2D
Reposted by Katherine Thomasset
AI-driven clinical decision support systems (AI-CDSS) provide clear benefits for people with #diabetes but clinical adoption remains challenging. To support safe & effective use, the EUDF has developed 14 recommendations. #AI #ArtificialIntelligence link.springer.com/article/10.1... 🔓
Artificial intelligence-driven clinical decision support systems to assist healthcare professionals and people with diabetes in Europe at the point of care: a Delphi-based consensus roadmap - Diabetol...
The use of artificial intelligence (AI) to improve the diagnosis, assessment and treatment of people with diabetes has the potential to drive a paradigm shift in diabetes care, both minimising treatme...
link.springer.com
November 28, 2025 at 2:10 PM
AI-driven clinical decision support systems (AI-CDSS) provide clear benefits for people with #diabetes but clinical adoption remains challenging. To support safe & effective use, the EUDF has developed 14 recommendations. #AI #ArtificialIntelligence link.springer.com/article/10.1... 🔓
Reposted by Katherine Thomasset
Loss of interpericyte tunnelling nanotubes is an early feature of diabetic retinal disease that precedes permanent vascular damage, offering a new perspective for the understanding of disease pathophysiology link.springer.com/article/10.1...
Interpericyte tunnelling nanotube loss in very early diabetic retinal disease - Diabetologia
Aims/hypothesis Interpericyte tunnelling nanotubes (IP-TNTs) regulate microvascular blood flow by coordinating pericyte–pericyte communication across distant capillaries in the retina. Perfusion abnor...
link.springer.com
December 1, 2025 at 8:29 AM
Loss of interpericyte tunnelling nanotubes is an early feature of diabetic retinal disease that precedes permanent vascular damage, offering a new perspective for the understanding of disease pathophysiology link.springer.com/article/10.1...
Safety and efficacy of efsubaglutide alfa, a long-acting #GLP-1RA, which significantly lowers #HbA1c and weight in drug-naive #T2D #DiabetesResearch
Efsubaglutide alfa, a long-acting GLP 1RA, significantly lowers HbA1c and weight in drug-naive #T2D. The seamless Phase IIb/III SUPER1 trial confirms efficacy and safety. #GLP1RA #Innogen link.springer.com/article/10.1...
Efficacy and safety of efsubaglutide alfa in individuals with type 2 diabetes (SUPER1): a randomised, double-blind, placebo-controlled, Phase IIb/III trial - Diabetologia
Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become an important option in clinical use for type 2 diabetes due to their dual benefits of glycaemic management and metaboli...
link.springer.com
December 3, 2025 at 11:01 AM
Safety and efficacy of efsubaglutide alfa, a long-acting #GLP-1RA, which significantly lowers #HbA1c and weight in drug-naive #T2D #DiabetesResearch
CXCR3 expression on antigen-experienced B cells is systemically dysregulated in #T1D #DiabetesResearch
CXCR3 on antigen-experienced B cells is dysregulated in type 1 diabetes #T1D #DiabetesResearch
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
CXCR3 expression on antigen-experienced B cells is systemically dysregulated in type 1 diabetes - Diabetologia
Aims/hypothesis The chemokine receptor C-X-C chemokine receptor type 3 (CXCR3) is a key chemoattractant molecule that facilitates the migration of activated T cells to the pancreas, leading to beta ce...
link.springer.com
December 3, 2025 at 11:00 AM
CXCR3 expression on antigen-experienced B cells is systemically dysregulated in #T1D #DiabetesResearch
Reposted by Katherine Thomasset
🌟 Meet Dr Francesca Cinti. Her work shows how islet innervation drives beta-cell de differentiation in #T2D, identifying a noradrenergic intrapancreatic signal as a promising therapeutic target.
📖 www.diabetesresearchclinicalpractice.com/article/S016...
Supported by @astra-zeneca.bsky.social.
📖 www.diabetesresearchclinicalpractice.com/article/S016...
Supported by @astra-zeneca.bsky.social.
December 2, 2025 at 2:34 PM
🌟 Meet Dr Francesca Cinti. Her work shows how islet innervation drives beta-cell de differentiation in #T2D, identifying a noradrenergic intrapancreatic signal as a promising therapeutic target.
📖 www.diabetesresearchclinicalpractice.com/article/S016...
Supported by @astra-zeneca.bsky.social.
📖 www.diabetesresearchclinicalpractice.com/article/S016...
Supported by @astra-zeneca.bsky.social.
Review highlighting key genetically anchored, empirically validated variant-to-function discoveries in #T2D and emerging tools turning non-coding variant insights into actionable mechanisms #DiabetesResearch #Genetics
Bridging the variant-to-function gap: review highlights key genetically anchored, empirically validated #V2F discoveries in #T2D and emerging tools turning non-coding variant insights into actionable mechanisms for #PrecisionMedicine link.springer.com/article/10.1... 🔓
Bridging the variant-to-function gap in type 2 diabetes: advances and challenges - Diabetologia
Type 2 diabetes is a polygenic, heterogeneous disease affecting over 530 million individuals worldwide, a number projected to rise to 1.3 billion by 2050. Genome-wide association studies have identifi...
link.springer.com
December 3, 2025 at 10:59 AM
Review highlighting key genetically anchored, empirically validated variant-to-function discoveries in #T2D and emerging tools turning non-coding variant insights into actionable mechanisms #DiabetesResearch #Genetics
Reposted by Katherine Thomasset
Our December cover represents ‘The Tantalus Plight of Mitochondria’, symbolic of mitochondrial substrate futility in diabetes. In this issue, Shi et al report leucine is a key contributor to mitochondrial dysfunction in diabetic kidney disease link.springer.com/article/10.1...
December 1, 2025 at 2:15 PM
Our December cover represents ‘The Tantalus Plight of Mitochondria’, symbolic of mitochondrial substrate futility in diabetes. In this issue, Shi et al report leucine is a key contributor to mitochondrial dysfunction in diabetic kidney disease link.springer.com/article/10.1...
How is #insulin production affected in residual beta cells in type 1 #diabetes? Préfontaine et al show unexpectedly that stressed senescent beta cells continue to produce mature insulin in the context of type 1 diabetes #DiabetesResearch #T1D #Islets link.springer.com/article/10.1... 🔓
Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia
Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, includi...
link.springer.com
November 28, 2025 at 9:36 AM
An updated glucose management indicator is a strong predictor of incident diabetic retinopathy in adults w/ type 1 #diabetes. The updated GMI (uGMI) could be complementary to HbA1c in diabetes care & predicting complications #DiabetesResearch #T1D #CGM link.springer.com/article/10.1... 🔓
Association of HbA1c and an updated glucose management indicator (uGMI) with incident diabetic retinopathy in adults with type 1 diabetes: a longitudinal study - Diabetologia
Aims/hypothesis This study aimed to compare the predictive performance of HbA1c and a continuous glucose monitoring (CGM)-based updated glucose management indicator (uGMI) in assessing incident diabet...
link.springer.com
November 28, 2025 at 9:34 AM
Classification of #diabetes into #subtypes predicts onset of #ESKD at an earlier stage, allowing for intervention #DiabetesResearch
Ahlqvist's machine learning-based #diabetes classification predicts onset of diabetic end-stage kidney disease at an early stage of diabetes, allowing clinicians to tailor intervention and prevention strategies to individual clusters
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
Diverse combination of factors associated with the development of diabetic kidney disease among data-driven diabetes subtypes: analysis of the J-DREAMS registry - Diabetologia
Aims/hypothesis Available methods for predicting the onset and progression of diabetic kidney disease (DKD) and end-stage kidney disease (ESKD) are not yet ready for clinical application. We used a Ja...
link.springer.com
November 28, 2025 at 9:32 AM
Classification of #diabetes into #subtypes predicts onset of #ESKD at an earlier stage, allowing for intervention #DiabetesResearch
Improving glycaemic management in adolescents with #T1D can help support cognition and learning #DiabetesResearch
Improving glycaemic management in adolescents may protect against the decline in #cognition, including deficits in spatial learning and navigation efficiency, associated with #T1D link.springer.com/article/10.1... 🔓
The virtual Morris water maze for cognitive function assessment in adolescents with type 1 diabetes - Diabetologia
Aims/hypothesis Neuropsychological assessments and neuroimaging techniques have indicated impaired spatial working memory in adolescents with type 1 diabetes. We investigated the influence of diabetes...
link.springer.com
November 28, 2025 at 9:30 AM
Improving glycaemic management in adolescents with #T1D can help support cognition and learning #DiabetesResearch
Reposted by Katherine Thomasset
It’s here: Our list of 100 Notable Books of 2025. www.nytimes.com/2025/11/24/b...
November 28, 2025 at 1:48 AM
It’s here: Our list of 100 Notable Books of 2025. www.nytimes.com/2025/11/24/b...
Reposted by Katherine Thomasset
The country wants a wealth tax on assets.
They're panicking because "won't the rich just leave" has been utterly debunked.
They've got no actual argument.
Join.greenparty.org.uk
They're panicking because "won't the rich just leave" has been utterly debunked.
They've got no actual argument.
Join.greenparty.org.uk
November 27, 2025 at 9:15 PM
The country wants a wealth tax on assets.
They're panicking because "won't the rich just leave" has been utterly debunked.
They've got no actual argument.
Join.greenparty.org.uk
They're panicking because "won't the rich just leave" has been utterly debunked.
They've got no actual argument.
Join.greenparty.org.uk
Lovely loop of Bristol Harbour this morning - Christmas lights are up! #running #thiswomanruns #womenrunners #runningwithfriends
November 28, 2025 at 9:28 AM
Lovely loop of Bristol Harbour this morning - Christmas lights are up! #running #thiswomanruns #womenrunners #runningwithfriends
Redosing of anti-CD3 Ab in a mouse model of #Type1Diabetes is safe and well tolerated but provides no added benefit #Immunotherapy #T1D #DiabetesResearch #Research
Repeated anti-CD3 dosing in new-onset #Type1Diabetes: no added benefit. ✅ Safe and well tolerated, but extra cost and effort bring no gain. #Immunotherapy #T1D #DiabetesResearch #Research #OpenAccess #Science link.springer.com/article/10.1... 🔓
Redosing of anti-CD3 antibodies in NOD mice with new-onset diabetes does not alter the effect of a single treatment course - Diabetologia
Aims/hypothesis Uncertainty exists regarding the effectiveness of redosing teplizumab, a humanised anti-CD3 monoclonal antibody, in individuals with stage 2 and 3 type 1 diabetes. This study aimed to ...
link.springer.com
November 25, 2025 at 3:24 PM
Redosing of anti-CD3 Ab in a mouse model of #Type1Diabetes is safe and well tolerated but provides no added benefit #Immunotherapy #T1D #DiabetesResearch #Research
Recurrent #hypoglycaemia promotes cardiac myopathy and increases cardiac vulnerability in a rodent model of type 1 #diabetes link.springer.com/article/10.1... 🔓
Recurrent hypoglycaemia promotes cardiomyopathy and cardiac vulnerability in a rodent model of type 1 diabetes - Diabetologia
Aims/hypothesis CVD remains the leading cause of mortality in individuals with type 1 diabetes over the age of 40 years. Although intensive insulin therapy lowers chronic hyperglycaemia and improves c...
link.springer.com
November 25, 2025 at 3:22 PM
Reposted by Katherine Thomasset
👇🎥 In case you missed it! On #WorldDiabetesDay2025, the EASD Early Career Academy hosted a webinar on “The role of the #placenta in diabetes” with Prof. Gernot Desoye.
The full recording is now available. Watch now 👉 www.youtube.com/watch?v=i8RI...
#diabetes #webinar #pregnancy
The full recording is now available. Watch now 👉 www.youtube.com/watch?v=i8RI...
#diabetes #webinar #pregnancy
November 21, 2025 at 2:00 PM
👇🎥 In case you missed it! On #WorldDiabetesDay2025, the EASD Early Career Academy hosted a webinar on “The role of the #placenta in diabetes” with Prof. Gernot Desoye.
The full recording is now available. Watch now 👉 www.youtube.com/watch?v=i8RI...
#diabetes #webinar #pregnancy
The full recording is now available. Watch now 👉 www.youtube.com/watch?v=i8RI...
#diabetes #webinar #pregnancy
The Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves #betacell function in stem cell-derived #islets under metabolic stress. #T1D #SC-islets #CellTherapy
Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - Diabetologia
Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...
link.springer.com
November 25, 2025 at 3:22 PM
The Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves #betacell function in stem cell-derived #islets under metabolic stress. #T1D #SC-islets #CellTherapy
Reposted by Katherine Thomasset
To prescribe or not to prescribe? #SGLT2 inhibitors slow #CKD progression, but it's unclear who with #T2D and mild/no CKD truly benefits. This new model predicts individual benefit, supporting more targeted prescribing. #PrecisionMedicine link.springer.com/article/10.1... 🔓
Precision medicine in type 2 diabetes: targeting SGLT2 inhibitor treatment for kidney protection - Diabetologia
Aims/hypothesis Current guidelines recommend use of sodium–glucose cotransporter-2 inhibitors (SGLT2 inhibitors) for kidney protection in people with type 2 diabetes and early-stage chronic kidney dis...
link.springer.com
November 21, 2025 at 7:43 AM
To prescribe or not to prescribe? #SGLT2 inhibitors slow #CKD progression, but it's unclear who with #T2D and mild/no CKD truly benefits. This new model predicts individual benefit, supporting more targeted prescribing. #PrecisionMedicine link.springer.com/article/10.1... 🔓
Study demonstrating how glycaemic management and BMI can influence cardiac autonomic markers in children with #T1D #DiabetesResearch
Cardiac autonomic markers were connected to disease duration and dysglycaemia in children with well-regulated type 1 #diabetes vs a matched healthy control group; in children with diabetes and overweight, cardiac autonomic regulation was impaired link.springer.com/article/10.1... 🔓
Influence of glycaemic management and BMI on cardiac autonomic markers in children with type 1 diabetes: a prospective cohort study - Diabetologia
Aims/hypothesis Our aim was to examine the presence of subclinical cardiovascular autonomic neuropathy (CAN) in a cohort of children with well-regulated type 1 diabetes by measuring baroreceptor sensi...
link.springer.com
November 25, 2025 at 3:20 PM
Study demonstrating how glycaemic management and BMI can influence cardiac autonomic markers in children with #T1D #DiabetesResearch
The peptide hormone spexin restores beta cell function by targetting the islet beta cell sodium–potassium pump in a mouse model of #diabetes #DiabetesResearch #Islets #BetaCells
Spexin targets islet beta cell sodium–potassium pump to increase insulin secretion and beta cell mass, leading to a decrease in glucose levels in diabetes mouse model. #DiabetesResearch #Islets #BetaCells link.springer.com/article/10.1... 🔓
Peptide hormone spexin restores beta cell function and improves glycaemic control in mice via regulation of the sodium–potassium pump - Diabetologia
Aims/hypothesis Clinical studies revealed that serum spexin level is positively associated with beta cell function. However, the role of spexin in beta cells remains unclear. We hypothesise that spexi...
link.springer.com
November 20, 2025 at 12:04 PM
The peptide hormone spexin restores beta cell function by targetting the islet beta cell sodium–potassium pump in a mouse model of #diabetes #DiabetesResearch #Islets #BetaCells
In Greek mythology, Tantalus stands in a pool of water beneath a laden fruit tree but when he reaches for fruit, the branches lift beyond his grasp. In diabetes, despite being immersed in nutrient-rich environments, mitochondria struggle to utilise these substrates for ATP production
Our December issue is online now! link.springer.com/journal/125/... @easdnews.bsky.social @springernature.com @springermedicine.com @hinmul.bsky.social
November 20, 2025 at 11:59 AM
In Greek mythology, Tantalus stands in a pool of water beneath a laden fruit tree but when he reaches for fruit, the branches lift beyond his grasp. In diabetes, despite being immersed in nutrient-rich environments, mitochondria struggle to utilise these substrates for ATP production
Reposted by Katherine Thomasset
Time to go after the companies that peddle this shit.
What a world. Toxicity pays: food, fossil fuels, X,and purveyors of disinformation.
Ultra-processed food linked to harm in every major human organ, study finds www.theguardian.com/society/2025...
What a world. Toxicity pays: food, fossil fuels, X,and purveyors of disinformation.
Ultra-processed food linked to harm in every major human organ, study finds www.theguardian.com/society/2025...
Ultra-processed food linked to harm in every major human organ, study finds
World’s largest scientific review warns consumption of UPFs poses seismic threat to global health and wellbeing
www.theguardian.com
November 19, 2025 at 8:57 AM
Time to go after the companies that peddle this shit.
What a world. Toxicity pays: food, fossil fuels, X,and purveyors of disinformation.
Ultra-processed food linked to harm in every major human organ, study finds www.theguardian.com/society/2025...
What a world. Toxicity pays: food, fossil fuels, X,and purveyors of disinformation.
Ultra-processed food linked to harm in every major human organ, study finds www.theguardian.com/society/2025...