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kroman.bsky.social
Karl Romanowicz
@kroman.bsky.social
260 followers 800 following 2 posts
Principal Scientist @synplexity.bsky.social Synthetic Biology and Bioinformatics
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kroman.bsky.social
Karl Romanowicz @kroman.bsky.social · Aug 16
Our new Science Advances paper is out! 🎉 The Plesa Lab's first, it builds on DropSynth technology as a proof of concept for large-scale synthetic gene libraries, showcasing a synthetic metagenomics approach to studying antibiotic resistance at scale. 👉 www.science.org/doi/10.1126/...
Exploring antibiotic resistance in diverse homologs of the dihydrofolate reductase protein family through broad mutational scanning
DropSynth technology enables scalable and cost-effective exploration of antibiotic resistance across the DHFR protein family.
www.science.org
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Reposted by Karl Romanowicz
varianteffect.bsky.social
Atlas of Variant Effects Alliance @varianteffect.bsky.social · Sep 3
Next up! Two applications of MAVE!
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (‪@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
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kroman.bsky.social
Karl Romanowicz @kroman.bsky.social · Aug 16
Our new Science Advances paper is out! 🎉 The Plesa Lab's first, it builds on DropSynth technology as a proof of concept for large-scale synthetic gene libraries, showcasing a synthetic metagenomics approach to studying antibiotic resistance at scale. 👉 www.science.org/doi/10.1126/...
Exploring antibiotic resistance in diverse homologs of the dihydrofolate reductase protein family through broad mutational scanning
DropSynth technology enables scalable and cost-effective exploration of antibiotic resistance across the DHFR protein family.
www.science.org
6 11
Reposted by Karl Romanowicz
synplexity.bsky.social
SynPlexity @synplexity.bsky.social · Mar 26
We unlock breakthrough insights by delivering the best training sets in biology—at unprecedented scale. youtu.be/KuCaJTPHM2o
Save 90% on DNA variant libraries today
YouTube video by IndieBio
youtu.be
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kroman.bsky.social
Karl Romanowicz @kroman.bsky.social · Feb 19
Permafrost thaw takes center stage on Ice & Fire Climate Change podcast! 🎙️❄️🔥

S2 Ep2 "Layer" & Ep3 "Microbes Reawaken" explore carbon release & climate impacts. Hear my research!

Tune in: iceandfireclimatepodcast.weebly.com/s2-permafros...

#ClimateChange #PermafrostResearch #SciComm
s2: permafrost thaw
podcast is available for listening on Apple Podcasts, Spotify, Overcast, and through the Public Radio Exchange (PRX) ​ ​ or listen below. Press "More Info" in each episode player to reveal show...
iceandfireclimatepodcast.weebly.com
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Reposted by Karl Romanowicz
calin.bsky.social
Calin Plesa @calin.bsky.social · Jan 28
New preprint! We carried out the largest complementation and inhibition study for diverse homologs in a single protein family (DHFR) to date. Highlights thread follows... 1/n 🧵
biorxivpreprint.bsky.social
bioRxivpreprint @biorxivpreprint.bsky.social · Jan 25
Exploring Antibiotic Resistance in Diverse Homologs of the Dihydrofolate Reductase Protein Family through Broad Mutational Scanning https://www.biorxiv.org/content/10.1101/2025.01.23.634126v1
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