Ian Kremer
@leadcoalition.bsky.social
9.8K followers 6.6K following 1.3K posts
Executive Director at the LEAD Coalition (a diverse, national coalition working to overcome #Alzheimers disease and other forms of #dementia). @umichlaw.bsky.social and WashU alum. You may have known me as @LEAD_Coalition on the bird site
Posts Media Videos Starter Packs
leadcoalition.bsky.social
Risk of stroke associated with risperidone in dementia with and without co-morbid cardiovascular disease: population-based matched cohort study www.cambridge.org/core/journal...

#Alzheimers #dementia #stroke #geriatrics #neurology #cardiology
Fig. 2
Kaplan–Meier plots depicting the cumulative incidence of stroke in matched controls and risperidone users. Blue dashed line indicates risperidone users. Shading represents 95% confidence intervals. CVD, cardiovascular disease.
Reposted by Ian Kremer
daniellebeckman.bsky.social
Viral trigger in Alzheimer’s disease is the real scary spooky #FluorescenceFriday.
Amyloid-β🟣 is an antimicrobial peptide that can be produced to trap pathogens in the brain. But it also induces an extensive neuroinflammatory response, as shown here with 🟠astrocytes. #NeuroCovid
Confocal microscopy photo showing astrocytes and amyloid-B
leadcoalition.bsky.social
Ms. GT, thank you so much for including me among so many wonderful people. Congressman Lewis reminded us about finding Good Trouble and finding joy. www.youtube.com/watch?v=4Qch...
Congressman John Lewis Dancing to Pharrell Williams' "Happy": "Nothing Can Bring Me Down"
YouTube video by Rachelle O'Neil
www.youtube.com
leadcoalition.bsky.social
Please share for every caregiver who has felt overwhelmed, inadequate and helpless: You don’t have to be perfect. Doing what you are able — the best that you are able, when you are able — is plenty.

(image via @jaybird54.bsky.social) #Alzheimers #dementia #autism #mentalhealth #caregiving
We need to normalize admitting when we’re overwhelmed. Like, genuinely saying, “I have seventeen things on my plate right now and adding one more might make me cry in a parking lot somewhere.”
leadcoalition.bsky.social
Please check out my new "Fearless" Starter Pack with lots of lovely folks bending the arc of the moral universe toward justice.
Reposted by Ian Kremer
therese88.bsky.social
Thought on
Kindness 💭
Thoughts on Kindness Picture of a aqua colored flower open and on it written 

"How beautiful a day can be when kindness touches it."
Reposted by Ian Kremer
leadcoalition.bsky.social
Researchers develop new method to track Alzheimer’s disease in real time www.strath.ac.uk/whystrathcly... by @unistrathclyde.bsky.social

#Alzheimers #dementia #health #wellness #science
Flat fiber-based photometry realizes fluorescent signals reflective of amyloid pathology in 5xFAD mice. (a) Flat fiber-based photometry system allows 405-nm LED light to pass through the flat fiber implanted in either 5xFAD or WT mouse brain. Emitted fluorescence light passes back through the flat fiber before being filtered to cut out excitation light and being focused onto a PMT. The light path was controlled by a series of mirrors (M), filters (F), and lenses (L). (b) Schematic of the experimental design. Mice were injected with Methoxy-X04 the day before being terminally anesthetized for photometry recordings. After, brain tissue was retrieved for histology, where photometry and histology signals underwent correlation analysis. Part of the diagram was created in BioRender. (c) Left: example in vivo fluorescent and post-mortem histology depth profiles. Solid line shows the median smoothed signal (window size: 4). Top right: coronal brain slice showing the flat fiber penetration track surrounded by Methoxy-X04-stained amyloid pathology. The white dashed line shows the penetration track. Scale: 1 mm. Bottom right: correlation analysis comparing photometry and histology depth profiles (r, Spearman’s rho). The black line shows a fitted linear regression. (d) Summary correlation coefficients across three different implant sites (two-sample t-test). 5xFAD, n=13 recordings from six mice. WT, n=11 recordings from seven mice. Squares, males; circles, females. (e) Classification performance based on in vivo photometry-based depth profiles.
leadcoalition.bsky.social
Just your friendly reminder that President Obama has a #NobelPrize. Though, to be fair, they hand those things out like candy -- my big brother got one also (but 10 years later and in economics, so it probably shouldn't count).
On this day in 2009, former President Barack Obama won the Nobel Peace Prize for what the Norwegian Nobel Committee called "his extraordinary efforts to strengthen international diplomacy and cooperation between peoples."
leadcoalition.bsky.social
Pets don't judge people living with dementia. People could learn a lot from pets.

(image: @allontheboard.bsky.social) #Alzheimers #dementia #kindness #poetry
"Pets love You 
Unconditionally 
And never talk about you 
Behind your back; 
Pets are loyal, 
They won't put you down 
Or tell you what you lack. 
Pets lessen loneliness 
And give you purpose every day; 
Pets keep you company, 
They make you smile and play. 
Pets help to reduce stress 
And are good for sanity, 
Pets can teach the human race 
So much about humanity." 

@allontheboard
leadcoalition.bsky.social
Thanks for thinking of me, Al. :-) Following most already and will check out the other folks!
leadcoalition.bsky.social
Antidepressant-Resistant Depression Increases Dementia Risk in Older Adults psychiatryadvisor.com/news/antidep... by @psychiatryadvisor.bsky.social

#Alzheimers #dementia #depression #mentalhealth #psychiatry #geriatrics #neurology
image of an older man staring blankly as pills fall all around him
leadcoalition.bsky.social
Let's all raise awareness about the power of #music in lives of people facing #Alzheimers disease and related forms of #dementia.

#happiness #quote
"Dear music, thank you for always clearing my head, healing my heart, and lifting my spirits." ~ Lori Deschene
leadcoalition.bsky.social
Thanks, Clay! Just to clarify, it is a social justice starter pack. I do that through work on Alzheimer's/dementia issues, others might do it on economics, environment, education, science, democracy, rule of law, or myriad other topics. Not left or right, but ethical or unethical.