@lealescouzeres.bsky.social
Post-doc in Patten Lab 🇨🇦
#zebrafish #neurodegenerative diseases 🧠🐟
#zebrafish #neurodegenerative diseases 🧠🐟
🎉 Excited to share our latest preprint📰 !
www.biorxiv.org/cgi/content/...
Many thanks to everyone involved in this project ! Using a zebrafish model 🐟 and iPSC-derived motor neurons 🔬 we show that restoring the calpastatin/calpain pathway preserves motoneuron survival and function in C9orf72 ALS!
www.biorxiv.org/cgi/content/...
Many thanks to everyone involved in this project ! Using a zebrafish model 🐟 and iPSC-derived motor neurons 🔬 we show that restoring the calpastatin/calpain pathway preserves motoneuron survival and function in C9orf72 ALS!
Therapeutic modulation of the calpastatin/calpain pathway restores calpain-mediated synaptic proteolysis and preserves motor neurons survival and function in C9orf72 ALS
A hexanucleotide repeat expansion (GGGGCC) in the C9orf72 gene is the most prevalent genetic cause of ALS, with early neuromuscular junction (NMJ) dysfunction being a key pathological feature. Current...
www.biorxiv.org
December 12, 2025 at 3:21 PM
🎉 Excited to share our latest preprint📰 !
www.biorxiv.org/cgi/content/...
Many thanks to everyone involved in this project ! Using a zebrafish model 🐟 and iPSC-derived motor neurons 🔬 we show that restoring the calpastatin/calpain pathway preserves motoneuron survival and function in C9orf72 ALS!
www.biorxiv.org/cgi/content/...
Many thanks to everyone involved in this project ! Using a zebrafish model 🐟 and iPSC-derived motor neurons 🔬 we show that restoring the calpastatin/calpain pathway preserves motoneuron survival and function in C9orf72 ALS!