Andreas Linkermann
@linkermannlab.bsky.social
Chair 5th Med Dept UMM, Heidelberg University
Kidney Transplantation and Cell Death Biology
Kidney Transplantation and Cell Death Biology
Pinned
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
www.nature.com
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Reviewing the paper by the Kats´ lab published today in #Cell, "Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia", I learned that cuproptosis is real! Here is my preview:
When heme is low, copper kills cancer:
www.cell.com/cell/fulltex...
When heme is low, copper kills cancer:
www.cell.com/cell/fulltex...
When heme is low, copper kills cancer
Heme carries oxygen and is critical for the control of redox reactions. In this issue
of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize
complex IV of the respirat...
www.cell.com
January 8, 2026 at 6:05 PM
Reviewing the paper by the Kats´ lab published today in #Cell, "Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia", I learned that cuproptosis is real! Here is my preview:
When heme is low, copper kills cancer:
www.cell.com/cell/fulltex...
When heme is low, copper kills cancer:
www.cell.com/cell/fulltex...
Here is a link to our most recent editorial for #CDDiff, Cell Death and Differentiation. It´s on work by Tony Letai and team.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
What does not kill you makes you Weaker! - Cell Death & Differentiation
Tumor cell evasion from regulated cell death is a hallmark of cancer [1]. Davern et al. now identify resistance to mitochondrial apoptosis to represent the common mechanism by which persister cells th...
www.nature.com
January 5, 2026 at 10:10 PM
Here is a link to our most recent editorial for #CDDiff, Cell Death and Differentiation. It´s on work by Tony Letai and team.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andreas Linkermann
Nature research paper: Erythropoietin receptor on cDC1s dictates immune tolerance
go.nature.com/496nEob
go.nature.com/496nEob
Erythropoietin receptor on cDC1s dictates immune tolerance - Nature
The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.
go.nature.com
December 17, 2025 at 9:11 AM
Nature research paper: Erythropoietin receptor on cDC1s dictates immune tolerance
go.nature.com/496nEob
go.nature.com/496nEob
Reposted by Andreas Linkermann
Obituary: David Baltimore (1938-2025) virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
go.nature.com/443Vojo
go.nature.com/443Vojo
David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.
go.nature.com
December 1, 2025 at 12:33 PM
Obituary: David Baltimore (1938-2025) virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
go.nature.com/443Vojo
go.nature.com/443Vojo
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E - Gavali - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E
Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...
advanced.onlinelibrary.wiley.com
November 4, 2025 at 11:57 AM
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E - Gavali - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Very pleased to share this "spotlight" in Trends in Endocrinology and Metabolism which refers to our recent work.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Hydroxyestradiol alleviates acute kidney injury via blockade of ferroptosis
The molecular mechanisms underlying sex differences in acute kidney injury (AKI) remain incompletely understood. In a study recently published in Natu…
www.sciencedirect.com
September 17, 2025 at 7:34 PM
Very pleased to share this "spotlight" in Trends in Endocrinology and Metabolism which refers to our recent work.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Here is a "highlight" on our recent work written by Boyi Gan for Cell Death and Differentiation:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury - Cell Death & Differentiation
Cell Death & Differentiation - Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury
www.nature.com
August 31, 2025 at 6:19 AM
Here is a "highlight" on our recent work written by Boyi Gan for Cell Death and Differentiation:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This refers to our recent manuscript.
Estrogen-powered kidney protection | Science Signaling www.science.org/doi/10.1126/...
Estrogen-powered kidney protection | Science Signaling www.science.org/doi/10.1126/...
Estrogen-powered kidney protection
Estrogen protects against kidney injury through both genomic and nongenomic mechanisms.
www.science.org
August 27, 2025 at 11:42 AM
This refers to our recent manuscript.
Estrogen-powered kidney protection | Science Signaling www.science.org/doi/10.1126/...
Estrogen-powered kidney protection | Science Signaling www.science.org/doi/10.1126/...
STING drives #necroptosis, and here’s how it does it!
Congratulations to @gianmaria-liccardi.bsky.social and his amazing team!
www.nature.com/articles/s41...
Congratulations to @gianmaria-liccardi.bsky.social and his amazing team!
www.nature.com/articles/s41...
STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD - Nature
Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD
www.nature.com
August 20, 2025 at 11:31 PM
STING drives #necroptosis, and here’s how it does it!
Congratulations to @gianmaria-liccardi.bsky.social and his amazing team!
www.nature.com/articles/s41...
Congratulations to @gianmaria-liccardi.bsky.social and his amazing team!
www.nature.com/articles/s41...
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
www.nature.com
August 19, 2025 at 8:57 AM
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Reposted by Andreas Linkermann
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
August 18, 2025 at 3:42 PM
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV