Author | Lightnews

Simon Little

@littleneuro.bsky.social

160 followers 170 following 6 posts

Neurologist & Neuroscientist interested in Brain Stimulation, Movement, Mood, Motivation, Sleep, Self Regulation, Psychology and Parenting

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Simon Little @littleneuro.bsky.social · Jun 27

Grateful to the big team and collaborators including Jeffrey Herron, Ph.D. and @gallantlab.org who helped make this possible as well as other members of littlelab.ucsf.edu

Little Lab, UCSF Neurology

littlelab.ucsf.edu

Simon Little @littleneuro.bsky.social · Jun 27

This was fully programmed using ML, remotely in patients own homes, addressing the challenges of increasing DBS programming complexity.

Simon Little @littleneuro.bsky.social · Jun 27

Happy to share our latest study led by Tanner Dixon and our team @ucsfhealth.bsky.social and @neurosurgucsf.bsky.social out today in Nature BME! Movement Responsive, AI programmed, BCI-aDBS improves naturalistic movements and reduces excessive movements at rest in PD.
www.nature.com/articles/s41...

Movement-responsive deep brain stimulation for Parkinson’s disease using a remotely optimized neural decoder - Nature Biomedical Engineering

An adaptive deep brain stimulation algorithm delivers targeted stimulation increases during movement using brain motor signals.

www.nature.com

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Reposted by Simon Little

Sam Gershman @gershbrain.bsky.social · Mar 31

I'd like to see a revival of panache and artistry in scientific prose style. Since we have to read so many papers, they should be fun and beautiful. I would also argue that this serves the goal of communication: readers will be more likely to remember a striking phrase or image.

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Simon Little @littleneuro.bsky.social · Jan 21

Happy to be launching this Special Edition in NPJ Parkinson’s on all things sleep and PD related

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Reposted by Simon Little

CLaE @claeneuro.bsky.social · Dec 21

Nature

Psilocybin desynchronizes the human brain
www.nature.com/articles/s41...

Psilocybin desynchronizes the human brain - Nature

Healthy adults were tracked before, during and after high doses of psilocybin and methylphenidate to assess how psychedelics can change human brain networks, and psilocybin was found to massively disr...

www.nature.com

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Reposted by Simon Little

Prof Rick Adams @drrickadams.bsky.social · Dec 20

This will build on amazing recent work by @melgaby.bsky.social and others, looking at how planning algorithms are encoded in prefrontal cortex circuits: bsky.app/profile/melg...

Mohamady El-Gaby @melgaby.bsky.social · Nov 25

A bit late to the Bluesky party but here’s our work showing a coordinate system for behavioural space, and an algorithm for computing behavioural sequences in the mFC: www.nature.com/articles/s41...

A cellular basis for mapping behavioural structure - Nature

Mice generalize complex task structures by using neurons in the medial frontal cortex that encode progress to task goals and embed behavioural sequences.

www.nature.com

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Simon Little @littleneuro.bsky.social · Dec 20

Great job Andy!!

Simon Little @littleneuro.bsky.social · Dec 19

Jimmy- you are the best and thoroughly deserved!!!

Reposted by Simon Little

Nature Portfolio @natureportfolio.nature.com · Dec 2

A study in Nature Medicine finds that deep brain stimulation of a region called the lateral hypothalamus improves walking and promotes recovery in humans and rodents with spinal cord injury. https://go.nature.com/3Vlosyl 🧪

This is figure 6, which shows that DBSLH mediates long-term improvements in walking in humans with SCI.

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