banner
loschmidtlab.bsky.social
@loschmidtlab.bsky.social
Our paper on FireProtDB 2.0 is accepted in Nucleic Acids Research! 🎉🔬
We've massively upgraded the essential database for computational protein design:
✅ 5.5 million stability experiments
✅ Now handles complex changes
✅ FAIR compliant & fully future-proofed

🔗 loschmidt.chemi.muni.cz/fireprotdb
November 26, 2025 at 12:19 PM
Big congratulations to 𝗝𝗮𝗻𝗮 𝗛𝗼𝗿𝗮𝗰𝗸𝗼𝘃𝗮, 𝗣𝗵𝗗, and 𝗝𝗮𝗻 𝗩𝗲𝗹𝗲𝗰𝗸𝘆, 𝗣𝗵𝗗! 🥳🎓

They both completed the Environmental Health Sciences doctoral degree programme at RECETOX, Faculty of Science, Masaryk University.
We wish Jana and Jan every success in their future endeavors. 🔬🚀

📸 Jiri Damborsky
November 21, 2025 at 3:09 PM
Great news from CLARA Days 2025! 🎉 Our post-doc, Saltuk Eyrilmez, gave a talk on "Recent progress in drug screening for apolipoprotein E"—a key protein in Alzheimer's disease pathogenesis.🧠

Saltuk: "Inspiring event & a unique opportunity to discuss my research with an interdisciplinary community."
November 19, 2025 at 12:06 PM
Our team leader, 𝗭𝗯𝘆𝗻𝗲𝗸 𝗣𝗿𝗼𝗸𝗼𝗽, was honored to join a key 𝗻𝗲𝘁𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝗲𝘃𝗲𝗻𝘁 hosted by the Ambassador of Switzerland to boost 🇨🇿-🇨🇭 science and innovation cooperation! 🤝 Great talks with researchers and reps from GA ČR/TA ČR about future joint initiatives. 🔬💡
November 14, 2025 at 9:57 AM
Listen to the latest interview with our doctoral student, 𝗗𝗮𝗻𝗶𝗲𝗹 𝗣𝗹𝘂𝘀𝗸𝗮𝗹! 🎙️ Daniel has won several prestigious awards, but he values his first win the most:

"It wasn't the biggest success, but it was my first success." 🥇

Big thanks to JCCM for supporting these young talents! 🙌
November 13, 2025 at 8:51 AM
📢 Our team leader, Zbynek Prokop, is giving a plenary lecture at the 8th International Conference on Microreactor Technology in Biotechnology (IMTB2026)! 🔬

📅 Mark your calendars: June 15, 2026, 9:00 AM in beautiful Bled, Slovenia 🇸🇮.

Catch the details here: imtb2026.fkkt.uni-lj.si
November 12, 2025 at 1:45 PM
Excellent science, stimulating discussions, and a fantastic atmosphere! That perfectly sums up the 𝗷𝗼𝗶𝗻𝘁 𝘄𝗼𝗿𝗸𝘀𝗵𝗼𝗽 held at the end of October between the research teams of Loschmidt Labs and CIIRC.
Thank you to our speakers, all participants, and the Horizon Europe #CLARA for making it possible! 🧠✨
November 10, 2025 at 12:26 PM
Huge thanks to Prof. 𝗠𝗮𝗿𝗰𝗼 𝗙𝗿𝗮𝗮𝗶𝗷𝗲 (U. Groningen) for his excellent talk at the MU Life Sciences Seminar!

He explained how enzymes utilize cofactors (such as metal ions or organic molecules) for life's crucial chemical reactions. Great interactive quiz and discussions over lunch with students!
November 7, 2025 at 11:42 AM
Thrilled to share insights from our recent feature in 𝗡𝗮𝘁𝘂𝗿𝗲 𝗖𝗼𝗺𝗺𝘂𝗻𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀, where 𝗦𝘁𝗮𝗻𝗶𝘀𝗹𝗮𝘃 𝗠𝗮𝘇𝘂𝗿𝗲𝗻𝗸𝗼, joined experts including 𝗥𝗲𝗯𝗲𝗰𝗰𝗮 𝗕𝘂𝗹𝗹𝗲𝗿 and 𝗬𝗮𝗻𝗴 𝗬𝗮𝗻𝗴 to discuss the game-changing role of machine learning in biocatalysis!

📰 Dive into the full interview here:
www.nature.com/articles/s41...
November 6, 2025 at 12:07 PM
The 𝗛𝗮𝗹𝗹𝗼𝘄𝗲𝗲𝗻 𝗽𝗮𝗿𝘁𝘆 is over! 🥳
It was a perfect chance to welcome new faces to our labs and enjoy some spooky fun together after work. 👻🧪 This time, we went full Halloween mode!

A big thanks to Martin Sitte for organizing the party!

📷 Jan Velecky & Karolina Sedlackova
November 5, 2025 at 11:53 AM
Our doctoral student, 𝗗𝗮𝗻𝗶𝗲𝗹 𝗣𝗹𝘂𝘀𝗸𝗮𝗹, spent three weeks at @VollmerLab, U. Exeter, gaining hands-on experience with their single-molecule biosensing technology. ⚛️ This allows tracking enzyme kinetics & protein dynamics at unprecedented timescales—down to single-atom movement!

📷 Daniel Pluskal
November 4, 2025 at 8:40 AM
Don't miss the CLARA Symposium, and particularly the presentation by our postdoc, 𝗦𝗮𝗹𝘁𝘂𝗸 𝗘𝘆𝗿𝗶𝗹𝗺𝗲𝘇, on Wednesday, 𝗡𝗼𝘃𝗲𝗺𝗯𝗲𝗿 𝟭𝟮, 𝗮𝘁 𝟭𝟯:𝟭𝟬 📆 ! The topic of his speech will be "Recent progress in drug screening for apolipoprotein E," which is a crucial protein in the pathogenesis of Alzheimer’s disease🧠.
October 31, 2025 at 8:39 AM
It was a pleasure hosting 𝗜𝘃𝗮𝗻𝗮 𝗧𝗶𝗺𝗸𝗼𝘃𝗮 (Center for Interdisciplinary Sciences at Pavol Jozef Šafárik University in Košice, Slovakia) at Loschmidt Labs! Ivana worked with David Kovar, mastering ultrasensitive fluorescence assays 🔦🧪— skills she'll use back home.

📷 Ivana Timkova
October 22, 2025 at 9:27 AM
Celebrating Loschmidt Labs' recent achievements:
- Congrats to Daniel Pluskal (Government Prize) & Martin Sitte (Best Poster)
- Kaja Sedlackova delivered her first presentation at the congress
- Our research has been accepted in top journals
- All instruments from the #CLARA project are installed
October 17, 2025 at 12:08 PM
We successfully held our 𝗼𝘂𝘁𝗿𝗲𝗮𝗰𝗵 𝘀𝗲𝗺𝗶𝗻𝗮𝗿 on October 10, 2025, at St. Anne's University Hospital in Brno! The day featured excellent talks and deep discussions on the progress of the #CLARA project. We wrapped up with fun team-building at Game Center, followed by a great gathering at Pivní Burza 🍻.
October 17, 2025 at 7:36 AM
Registration is now open for the 𝟳𝘁𝗵 𝗛𝗮𝗻𝗱𝘀-𝗼𝗻 𝗖𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗘𝗻𝘇𝘆𝗺𝗲 𝗗𝗲𝘀𝗶𝗴𝗻 𝗖𝗼𝘂𝗿𝘀𝗲! 🚀

Ready to become a protein design wizard? 🧙‍♂️🧙‍♀️ This course gives you hands-on experience and a solid foundation, regardless of your background.

Secure your spot:
🔗 loschmidt.chemi.muni.cz/academy/
October 15, 2025 at 8:28 AM
Excited to share our new article in @febsopenbio.bsky.social!

We created optimized biochemical tests 🧪 to rapidly screen and validate clot-dissolving drugs (for stroke, pulmonary embolism, etc.).

🔗 febs.onlinelibrary.wiley.com/doi/10.1002/...
October 8, 2025 at 11:39 AM
The 𝗚𝗼𝘃𝗲𝗿𝗻𝗺𝗲𝗻𝘁 𝗔𝘄𝗮𝗿𝗱 𝗳𝗼𝗿 𝗧𝗮𝗹𝗲𝗻𝘁𝗲𝗱 𝗦𝘁𝘂𝗱𝗲𝗻𝘁𝘀 𝟮𝟬𝟮𝟰 goes to our doctoral student, Daniel Pluskal! Congratulations to Daniel and his supervisor, Martin Marek, on this achievement! 👏

📷 Office of the Government of the Czech Republic
October 6, 2025 at 10:45 AM
✨ Exciting News! ✨ We are thrilled to invite you to the 𝟳𝘁𝗵 𝗛𝗮𝗻𝗱𝘀-𝗼𝗻 𝗖𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗘𝗻𝘇𝘆𝗺𝗲 𝗗𝗲𝘀𝗶𝗴𝗻 𝗖𝗼𝘂𝗿𝘀𝗲!
📅 9–13 February 2026 | 🌐 Online
🔔 Registration opens on 14 October!
🚀 This interactive 5-day training blends essential enzyme engineering theory with hands-on practice using cutting-edge tools.
October 2, 2025 at 11:17 AM
𝗡𝗼𝗰 𝘃𝗲̌𝗱𝗰𝘂̊ 𝟮𝟬𝟮𝟱 na téma Bohatství 💰 je za námi a rozhodně se vydařila!
Děkujeme všem návštěvníkům, kteří se u nás zastavili, vyzkoušeli si naše experimenty a ptali se na to, co je zajímalo. ⚗️🧪🔬 Byla to skvělá příležitost ukázat, že věda může být nejen poučná, ale i zábavná! ✨
Těšíme se zase příště!
September 30, 2025 at 10:00 AM
Our article, "𝗤𝘂𝗮𝗻𝘁𝘂𝗺 𝗖𝗼𝗺𝗽𝘂𝘁𝗶𝗻𝗴 𝗳𝗼𝗿 𝗙𝗮𝘀𝘁𝗲𝗿 𝗘𝗻𝘇𝘆𝗺𝗲 𝗗𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 𝗮𝗻𝗱 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴," accepted by 𝗡𝗮𝘁𝘂𝗿𝗲 𝗖𝗮𝘁𝗮𝗹𝘆𝘀𝗶𝘀! 🥳 This perspective co-authored with P. Kouba & J. Sivic (CIIRC CTU in Prague), explores how quantum algorithms can tackle biocatalysis challenges that are impossible for classical computing.
September 29, 2025 at 4:45 AM
Už dnes! 𝗡𝗼𝗰 𝘃𝗲̌𝗱𝗰𝘂̊ je tady! 🔬

Přijďte poznat neviditelný svět! Chcete zjistit, jak vypadají miliardy bakterií 🦠, které nosíte na sobě? Ukážeme vám, jak si je vypěstovat z vlastního těla! Máme i neobvyklou ochutnávku toho, čím se mikrobi živí.

Přijďte se podívat, ochutnat a zkusit! Těšíme se! 😉
September 26, 2025 at 7:47 AM
𝗡𝗼𝗰 𝘃𝗲̌𝗱𝗰𝘂̊ 𝟮𝟬𝟮𝟱 - už tento pátek!
Nezapomeňte se zastavit do Loschmidtových laboratoří v Univerzitním kampusu v Bohunicích. Dozvíte se, proč světluška svítí 💡, jak se vyrábí umělé maso 🥩, nebo si uděláte otisk prstu na živnou půdu 🧫. Těšíme se na Vás 𝟮𝟲.𝟵. 𝗼𝗱 𝟭𝟳 𝗵𝗼𝗱𝗶𝗻! 🕓
September 24, 2025 at 12:05 PM
We recently said goodbye to Anthony Legrand, moving on from his postdoctoral research role at LL. We celebrated his time with a Hawaiian-themed barbecue. We're grateful for his contributions and wish him the best in his future endeavours!

📸 Karolina Sedlackova
September 22, 2025 at 8:01 AM
Our new article, focusing on the effects of N-terminal His-tagging on staphylokinase (SAK) variants, has been accepted by the 𝗜𝗻𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗝𝗼𝘂𝗿𝗻𝗮𝗹 𝗼𝗳 𝗕𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗠𝗮𝗰𝗿𝗼𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗲𝘀!

🔗 Read the full article here:
www.sciencedirect.com/science/arti...
September 19, 2025 at 11:22 AM