@lykkesylow.bsky.social
Super happy to share our latest study on muscle remodeling in human cachexia in patients with lung cancer: www.biorxiv.org/content/10.1...
www.biorxiv.org
November 21, 2025 at 1:12 PM
Super happy to share our latest study on muscle remodeling in human cachexia in patients with lung cancer: www.biorxiv.org/content/10.1...
🐭❄️ Temperature impacts molecular changes linked to cancer & cachexia in mouse models -something to consider when interpreting preclinical results and their translation to human cancers.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Housing Temperature Impacts the Systemic and Tissue‐Specific Molecular Responses to Cancer in Mice
Background Cancer cachexia, affecting up to 80% of patients with cancer, is characterized by muscle and fat loss with functional decline. Preclinical research seeks to uncover the molecular mechanis...
onlinelibrary.wiley.com
April 22, 2025 at 2:40 PM
🐭❄️ Temperature impacts molecular changes linked to cancer & cachexia in mouse models -something to consider when interpreting preclinical results and their translation to human cancers.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
I recently had the pleasure of discussing one of my favorite topics: how exercise benefits our health and helps protect against diseases like cancer and diabetes. Grateful for the opportunity to share! If you're interested, you can listen here 😊🙏
www.sciencestories.dk/en/articles/...
www.sciencestories.dk/en/articles/...
Obesity, mobility, exercise and cancer are related
More signs of benefits from exercise.
www.sciencestories.dk
March 17, 2025 at 2:03 PM
I recently had the pleasure of discussing one of my favorite topics: how exercise benefits our health and helps protect against diseases like cancer and diabetes. Grateful for the opportunity to share! If you're interested, you can listen here 😊🙏
www.sciencestories.dk/en/articles/...
www.sciencestories.dk/en/articles/...
Reposted
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
www.nature.com
January 6, 2025 at 2:44 PM
Curious about muscle metabolism? 🚴♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
Reposted
In our latest study, we found that the mitochondrial (mt) protein SLIRP is a PGC-1α target that regulates mt structure, respiration, and mt-mRNA in muscle. And exercise restored these functions, even with SLIRP disruption and low mt-mRNA! www.nature.com/articles/s41...
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms - Nature Communications
Muscle mass is lost in patients with diabetes, which is associated with mitochondrial disfunction. Here they show that SLIRP maintains muscle mitochondria and that exercise training can compensate for...
www.nature.com
November 18, 2024 at 8:16 AM
In our latest study, we found that the mitochondrial (mt) protein SLIRP is a PGC-1α target that regulates mt structure, respiration, and mt-mRNA in muscle. And exercise restored these functions, even with SLIRP disruption and low mt-mRNA! www.nature.com/articles/s41...
In our latest study, we found that the mitochondrial (mt) protein SLIRP is a PGC-1α target that regulates mt structure, respiration, and mt-mRNA in muscle. And exercise restored these functions, even with SLIRP disruption and low mt-mRNA! www.nature.com/articles/s41...
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms - Nature Communications
Muscle mass is lost in patients with diabetes, which is associated with mitochondrial disfunction. Here they show that SLIRP maintains muscle mitochondria and that exercise training can compensate for...
www.nature.com
November 18, 2024 at 8:16 AM
In our latest study, we found that the mitochondrial (mt) protein SLIRP is a PGC-1α target that regulates mt structure, respiration, and mt-mRNA in muscle. And exercise restored these functions, even with SLIRP disruption and low mt-mRNA! www.nature.com/articles/s41...