J Magarian Blander
@magarianblander.bsky.social
390 followers 330 following 9 posts
Armenian American Scientist studies immune responses to #microbes, #tissueinjury, & earliest stages of #cancer. Professor, Head of Biomedical Research Lab https://www.theblanderlab.org #macrophage #Dendriticcell #inflammasome #celldeath #Tcell
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magarianblander.bsky.social
Thrilled to see two of my former postdocs, @gaetanbarbet.bsky.social ‬⁩ and Johan Garaude, shining on the speaker list at the @frenchdcsociety.bsky.social Biennial Meeting, @pasteur.fr ! Proud of their amazing work and contributions to the field! #Dendriticcell #ProudMentor
magarianblander.bsky.social
Vita-PAMP bacterial mRNA+LPS in sterile tissue = potentially dangerous live bacteria, & like virulence factors, activate the noncanonical NLRP3 inflammasome. Find out the common & distinct features of activating this pathway by a vita-PAMP vs virulence factor:
www.sciencedirect.com/science/arti...
Two modes of noncanonical NLRP3 inflammasome activation in response to distinct viability patterns of Gram-negative bacteria.
magarianblander.bsky.social
Macrophages help tumors grow, but what about early on when transformed cells first arise in tissue? Macrophages may collaborate with the cell-intrinsic barriers to transformation in a form of ‘oncogenic monitoring’. Curious? My hypothesis full text here till 2/15
authors.elsevier.com/a/1kKoc3OeyG...
Integrated oncogenic monitoring in premalignant tissue.