Matthias Mann | Lightnews

Mann Lab

@mannlab.bsky.social

680 followers 1 following 110 posts

The Mann Lab is a pioneer in mass spectrometry-based proteomics. Posts represent personal views from lab members and Matthias Mann

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Matthias Mann is a German physicist and biochemist. He is doing research in the area of mass spectrometry and proteomics.

Source: Wikipedia

Biology 49%

Chemistry 44%

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Mann Lab @mannlab.bsky.social · Jul 1

Thank you Matthias for your visionary leadership and for creating a scientific family that continues to push boundaries. Congratulations from all members, and looking forward to the future! #MS #Proteomics #20Years

Max Planck Institute of Biochemistry @mpibiochem.bsky.social · Jul 1

🎉 Congratulations to Matthias Mann on 20 years leading Proteomics & Signal Transduction at MPI of Biochemistry! Two decades of groundbreaking mass spectrometry research and training excellent future scientists.

#MS #Proteomics #Science @mannlab.bsky.social

Mann Lab @mannlab.bsky.social · 20h

Honored to be included in this reflection on 20 excellent years of MolSystBiol! From our first phosphotyrosine interactome in 2005 to proteome-wide networks - scale has grown exponentially. MS proteomics + AI is transforming systems-level understanding. Exciting times!
embopress.org/doi/pdf/10.1...

embopress.org

Mann Lab @mannlab.bsky.social · 8d

Elegant chemistry and cryo-EM explain the selective Lys8 ubiquitylation. A clear example of how metabolite sensing and the ubiquitin system intersect.

Mann Lab @mannlab.bsky.social · 8d

Great to see Brenda Schulman’s team post their new bioRxiv paper. MS-based proteomics helped uncover a beautifully simple mechanism: cysteine levels tune metabolism by flipping the inverse stability of LRRC58 and its substrate CDO1.
www.biorxiv.org/content/bior...

www.biorxiv.org

Mann Lab @mannlab.bsky.social · 12d

Fantastic time at #HUPO2025 in Toronto! Congratulations to our talented Early Career researchers! Proud winners: Oeller Marc Oeller🥇 1st Place Poster, Kathrin Korff 🥈 Runner-up Poster, and @carolineweiss.bsky.social 🎤 3-Minute Thesis award! The future of #proteomics research is bright!

Mann Lab @mannlab.bsky.social · 18d

If you are at HUPO 2025, catch up with our team @mannlab.bsky.social to hear about our exciting work in single-cell proteomics, immunopeptidomics, spatial proteomics, and the latest advances in mass spectrometry technology!

Mann Lab @mannlab.bsky.social · 25d

In Nature Communications: MS-based proteomics + machine learning to diagnose Lyme neuroborreliosis with 92% accuracy (CSF) and 80% (blood) - paving the way for earlier, less invasive testing.
www.nature.com/articles/s41...

The diagnostic potential of proteomics and machine learning in Lyme neuroborreliosis - Nature Communications

Researchers incorporate mass spectrometry-based proteomics and machine learning to assess the potential of a less invasive diagnostic approach for Lyme neuroborreliosis, a common nervous system infect...

www.nature.com

Mann Lab @mannlab.bsky.social · 28d

Awesome talk by @erictopol.bsky.social at the Bavarian Academy of Sciences and Humanities (BAdW). A positive and hopeful take on #AI in medicine. Thanks for highlighting #DVP, too 😊

Mann Lab @mannlab.bsky.social · Oct 22

AlphaDIA is open-source and free for academic and commercial users. We are currently preparing version 2.0 - stay tuned!
#AlphaDIA #Bioinformatics #DeepLearning #MassSpectrometry

Mann Lab @mannlab.bsky.social · Oct 22

Excited to share AlphaDIA's publication in Nature Biotechnology!
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...

AlphaDIA enables DIA transfer learning for feature-free proteomics - Nature Biotechnology

An open-source platform for data-independent acquisition proteomics adapts predicted libraries to experimental settings.

www.nature.com

Mann Lab @mannlab.bsky.social · Oct 9

How much hands-on lab expertise gets lost? We developed a multimodal AI agent that turns videos into protocols and detects procedural errors. Making science accessible. Great collaboration with #Google.
Preprint: www.biorxiv.org/content/10.1...
@patiskowronek.bsky.social explains👇

Patricia Skowronek @patiskowronek.bsky.social · Oct 8

In labs, hands-on expertise is often lost because it's not written down. We leverage multimodal AI agents to capture & share expertise by analyzing video and speech to generate protocols, detect errors, and guide researchers. #AI #TeamMassSpec
📄 Preprint: doi.org/10.1101/2025... 1/🧵

Multimodal AI agents for capturing and sharing laboratory practice

We present a multimodal AI laboratory agent that captures and shares tacit experimental practice by linking written instructions with hands-on laboratory work through the analysis of video, speech, an...

doi.org

Reposted by Matthias Mann

Patricia Skowronek @patiskowronek.bsky.social · Oct 8

Multimodal AI agents for capturing and sharing laboratory practice

doi.org