Mari B. Gornitzka
@maribgo.bsky.social
PhD fellow in immunogenetics @ University of Oslo |
I like ripped genes, long genes, baggy genes and double genes
I like ripped genes, long genes, baggy genes and double genes
Reposted by Mari B. Gornitzka
New BCR reconstruction tool for scRNA-seq: assembles full heavy & light chains and annotates constant regions. Check it out:
www.biorxiv.org/content/10.1...
#scRNAseq #immunology
www.biorxiv.org/content/10.1...
#scRNAseq #immunology
GATHeR: Graph-based Accurate Tool for Immunoglobulin HEavy- and Light-chain Reconstruction
Recovering full-length, paired B-cell receptor (BCR) sequences from scRNA-seq reads remains difficult, especially in naive and memory B cells where immunoglobulin transcripts are sparse. Current metho...
www.biorxiv.org
September 22, 2025 at 4:50 AM
New BCR reconstruction tool for scRNA-seq: assembles full heavy & light chains and annotates constant regions. Check it out:
www.biorxiv.org/content/10.1...
#scRNAseq #immunology
www.biorxiv.org/content/10.1...
#scRNAseq #immunology
Interested in BCR analysis, including paired heavy-light chain and constant region?👀 Check out our new tool for reconstructing BCRs from scRNAseq! Compatible with 10x and Smart-seq🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
GATHeR: Graph-based Accurate Tool for Immunoglobulin HEavy- and Light-chain Reconstruction
Recovering full-length, paired B-cell receptor (BCR) sequences from scRNA-seq reads remains difficult, especially in naive and memory B cells where immunoglobulin transcripts are sparse. Current metho...
www.biorxiv.org
September 22, 2025 at 11:46 AM
Interested in BCR analysis, including paired heavy-light chain and constant region?👀 Check out our new tool for reconstructing BCRs from scRNAseq! Compatible with 10x and Smart-seq🧬
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
*constant*ly amazed 🧬
Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations
The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...
www.biorxiv.org
February 14, 2025 at 9:17 AM
*constant*ly amazed 🧬
Reposted by Mari B. Gornitzka
Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locus
Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive seq...
www.biorxiv.org
December 18, 2024 at 3:21 PM
Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mari B. Gornitzka
Our collaborative paper on #Nanopore sequencing is now available on #BioRxiv. Among several new variants, we characterize a large duplication in the IGHC region, suggesting non-canonical class switching between the duplicated isotypes in #Bcells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 18, 2024 at 10:08 AM
Our collaborative paper on #Nanopore sequencing is now available on #BioRxiv. Among several new variants, we characterize a large duplication in the IGHC region, suggesting non-canonical class switching between the duplicated isotypes in #Bcells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...